Brian Cuzzo,Andrew Lipsky,Hua-Jay J Cherng
Brian Cuzzo
Purpose of review: The utility of analyzing circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and disease in the bone marrow as an adjunctive tool in caring for hematologic cancer patients is expanding. This ...
Updates in the Classification of T-cell Lymphomas and Lymphoproliferative Disorders [0.03%]
T细胞淋巴瘤和淋巴增生性疾病的分类更新
Naoki Oishi,Reham Ahmed,Andrew L Feldman
Naoki Oishi
Purpose of review: Mature T/NK-cell neoplasms comprise a heterogeneous group of diseases with diverse clinical, histopathologic, immunophenotypic, and molecular features. A clinically relevant, comprehensive, and reproduc...
Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders [0.03%]
染色体生物学障碍患者的遗传咨询和家庭筛查建议
Laura Ongie,Hannah A Raj,Katie Barrett Stevens
Laura Ongie
Purpose of review: Telomere biology disorders (TBDs) encompass a spectrum of genetic diseases with a common pathogenesis of defects in telomerase function and telomere maintenance causing extremely short telomere lengths....
NK Cell Therapeutics for Hematologic Malignancies: from Potential to Fruition [0.03%]
NK细胞治疗血液系统恶性肿瘤：从潜力走向现实
Stephanie L Fetzko,Leander D Timothy,Robin Parihar
Stephanie L Fetzko
Purpose of review: The current review focuses on the preclinical development and clinical advances of natural killer (NK) cell therapeutics for hematologic malignancies and offers perspective on the unmet challenges that ...
Nicholas J Short,Jayastu Senapati,Elias Jabbour
Nicholas J Short
Purpose of review: While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are expected to have a normal life expectancy, some patients present with or progress to a more aggressive accelera...
Eleanor P Taranto,Stefan K Barta,Rahul S Bhansali
Eleanor P Taranto
Purpose of review: T and NK cell lymphomas are relatively rare and heterogeneous forms of non-Hodgkin lymphoma that are associated with high rates of mortality. Central nervous system relapse carries significant morbidity...
Maegan Ford,Evelyn Orlando,Jennifer Effie Amengual
Maegan Ford
Purpose of review: Epstein-Barr Virus (EBV) is a ubiquitous herpesvirus that affects almost all humans and establishes lifelong infections by infecting B-lymphocytes leading to their immortalization. EBV has a discrete li...
Developing Targeted Therapies for T Cell Acute Lymphoblastic Leukemia/Lymphoma [0.03%]
T细胞急性淋巴细胞白血病/淋巴瘤的靶向治疗研究
Adam S DuVall,Austin Wesevich,Richard A Larson
Adam S DuVall
Purpose of review: Largely, treatment advances in relapsed and/or refractory acute lymphoblastic leukemia (ALL) have been made in B cell disease leaving T cell ALL reliant upon high-intensity chemotherapy. Recent advances...
Financial Toxicity in Patients with Hematologic Malignancies: a Review and Need for Interventions [0.03%]
血液系统恶性肿瘤患者的财务毒性：综述及干预需求分析
Megan Sears-Smith,Thomas G Knight
Megan Sears-Smith
Introduction: Financial toxicity is a developing research area to quantify the financial stress experienced by patients and caregivers, as well as the mechanisms by which they manage the costs associated with treatment an...
Kelsey Beck,Tyler Sandahl,Sikander Ailawadhi et al.
Kelsey Beck et al.
Purpose of review: The treatment landscape of multiple myeloma (MM) has evolved resulting in MM becoming a chronic condition. The costs of MM therapies are substantial and compound as patients remain on long-term maintena...