Richard J Lin,Parastoo B Dahi,Beatriz Korc-Grodzicki et al.
Richard J Lin et al.
Purpose of review: Hematologic malignances more commonly affect older individuals and often present with advanced, higher risk disease than younger patients. Allogeneic and autologous hematopoietic cell transplantation is...
Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders [0.03%]
端粒生物学障碍患者肺部、肝脏和同种异体造血干细胞移植
Kelly M Pennington,Douglas Simonetto,Timucin Taner et al.
Kelly M Pennington et al.
Purpose of the review: This study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with telomere biology disorders (TBD). Specifically, this review focuses o...
Parathan Karunakaran,Nidhi Jain,Deepesh P Lad
Parathan Karunakaran
Purpose of review: Chronic lymphocytic leukemia was an ignored leukemia in India until a decade back, given its low prevalence and absence of novel drugs to treat it. Healthcare in India is heterogeneous, with variations ...
Amneet Bajwa,Alma Habib,Adam S Kittai
Amneet Bajwa
Purpose of review: This review presents recently published clinical trial data and ongoing investigations regarding the treatment of Richter's transformation (RT). ...
Diagnosis and Management of Pulmonary Manifestations of Telomere Biology Disorders [0.03%]
端粒生物学障碍的肺表现的诊断和管理
Kathryn T Del Valle,Eva M Carmona
Kathryn T Del Valle
Purpose of review: Telomere biology disorders (TBD) are a group of genetic disorders characterized by premature shortening of telomeres, resulting in accelerated aging of somatic cells. This often leads to major multisyst...
Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders [0.03%]
端粒病的适应性和非适应性克隆造血功能
Terra Lasho,Mrinal M Patnaik
Terra Lasho
Purpose of review: Telomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated shortening of telomeres, predisposition to organ-failure syndromes, and...
Jeffrey Lantz,Natalie Pham,Caroline Jones et al.
Jeffrey Lantz et al.
Purpose of review: Acute lymphoblastic leukemia (ALL) is a rare hematologic neoplasm in adults, with most cases defined by pathology related to abnormal B cell proliferation known as B-cell ALL. The course is challenging,...
Hong De Sa,Jessica Leonard
Hong De Sa
Purpose of review: Acute lymphoblastic leukemia (ALL) is a widely heterogeneous disease in terms of genomic alterations, treatment options, and prognosis. While ALL is considered largely curable in children, adults tend t...
Unlocking the Potential of Artificial Intelligence in Acute Myeloid Leukemia and Myelodysplastic Syndromes [0.03%]
解锁人工智能在急性髓系白血病和骨髓增生异常综合征中的潜力
Abdulrahman Alhajahjeh,Aziz Nazha
Abdulrahman Alhajahjeh
Purpose of the review: This review aims to elucidate the transformative impact and potential of machine learning (ML) in the diagnosis, prognosis, and clinical management of myelodysplastic syndromes (MDS) and acute myelo...
Experimental and Computational Approaches to Measure Telomere Length: Recent Advances and Future Directions [0.03%]
测量端粒长度的实验和计算方法：近期进展与未来方向
Alejandro Ferrer,Zachary D Stephens,Jean-Pierre A Kocher
Alejandro Ferrer
Purpose of review: The length of telomeres, protective structures at the chromosome ends, is a well-established biomarker for pathological conditions including multisystemic syndromes called telomere biology disorders. Ap...