Molecular Pathogenesis and Targeted Therapies for Myeloproliferative Hypereosinophilic Neoplasms [0.03%]
髓系增生性高嗜酸粒细胞白血病的分子病理和靶向治疗
Colette Hanna,Joe Rizkallah,Nicole Charbel et al.
Colette Hanna et al.
Purpose of Review: This review examines the rapidly evolving landscape of myeloproliferative hypereosinophilic syndromes (HES) and related neoplasms. We aim to synthesize current understanding of their diverse molecular d...
The Intricate Dance Between Inflammation and Myeloproliferative Neoplasms: From Origins to Outcomes [0.03%]
炎症与髓系增生性肿瘤之间的复杂关系：从起源到结局
Angela G Fleischman
Angela G Fleischman
Purpose of review: Myeloproliferative neoplasms (MPNs) lie at the intersection of malignancy and chronic inflammatory disease. This review summarizes current understanding of how inflammation drives MPN pathogenesis, from...
When Targeted Therapy Falls Short: Unraveling Resistance Mechanisms in Chronic Lymphocytic Leukemia [0.03%]
靶向治疗失效时：慢性淋巴细胞白血病耐药机制解析
Samon Benrashid,Jennifer A Woyach
Samon Benrashid
Purpose of Review: Targeted therapies have revolutionized the treatment of chronic lymphocytic leukemia (CLL), however the disease remains incurable. This is largely due to somatic mutations in proteins targeted by these ...
Inotuzumab Ozogamicin in Clinical Practice: an Overview of Efficacy, Safety, and Real-World Applications [0.03%]
伊尼妥单抗临床应用：疗效、安全性和真实世界案例分析概述
Valerie Tran,Nandan Srinivasa,Caroline Tatum et al.
Valerie Tran et al.
Purpose of review: Acute lymphoblastic leukemia (ALL) is a rare hematologic malignancy with a bimodal distribution of incidence in both pediatric/young adult and elderly patient populations. Despite the high complete remi...
New Approaches for Measurable Residual Disease Assessment in Multiple Myeloma: Integrating NGS, Mass Spectrometry, and Next-Generation Flow Cytometry to Monitor Treatment Response [0.03%]
多发性骨髓瘤的可测量残留疾病评估的新方法：整合NGS、质谱和下一代流式细胞术以监测治疗反应
Bhavesh Mohan Lal,Shaji K Kumar
Bhavesh Mohan Lal
Purpose of review: Measurable residual disease (MRD) has emerged as the strongest prognostic biomarker in multiple myeloma (MM), providing a deeper assessment of treatment response than conventional serological tests. Sen...
Valentina Boldrini,Paola Guglielmelli,Alessandro M Vannucchi
Valentina Boldrini
Purpose of the review: Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) characterized by splenomegaly, constitutional symptoms, bone marrow fibrosis and potential progression to a blast phase. This review provide...
Advances and Controversies in the Management of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Navigating First-Line Therapies [0.03%]
费城染色体阳性急性淋巴细胞白血病的一线治疗管理进展与争议：探索之路
Talia Zahra,Nadia Bambace,Lyle Feinstein et al.
Talia Zahra et al.
Purpose of review: The goal of this review is to provide an updated synthesis of therapeutic advances and remaining controversies in the management of Philadelphia chromosome-positive (Ph +) B-cell acute lymphoblastic leu...
Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers [0.03%]
理解三阴性骨髓增生性肿瘤并识别分子驱动因素
Valentina Boldrini,Giuseppe G Loscocco,Paola Guglielmelli et al.
Valentina Boldrini et al.
Impact of Germline DNA Repair Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Development [0.03%]
胚系DNA修复突变对克隆造血和髓系肿瘤发生的影响
Kateryna Fedorov,Leo Y Luo,Alexander G Bick et al.
Kateryna Fedorov et al.
Purpose of review: Clonal hematopoiesis (CH) arises from the expansion of a single hematopoietic stem cell harboring somatic mutations that confer growth advantage. Recent studies highlight a substantial heritable compone...
Saman Ghalamkari,Christopher N Hahn,Amelia Lau et al.
Saman Ghalamkari et al.
Purpose of review: Despite increased recognition of FPDMM and advancements in genetic technologies that have improved carrier identification and our understanding of RUNX1 function, the mechanisms driving hematologic mali...