Xu-Jie Zhou,Hong Zhang
Xu-Jie Zhou
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a considerable lifetime risk of kidney failure. The etiology of IgAN, however, remains incompletely understood, and effective treatment is lacking. Alt...
Emerging Biochemical and Immunologic Mechanisms in the Pathogenesis of IgA Nephropathy [0.03%]
免疫球蛋白A肾小球肾炎发病中的生化和免疫新机制
Jan Novak,Colin Reily,Nicholas J Steers et al.
Jan Novak et al.
IgA nephropathy is a mesangioproliferative glomerular disease with significant morbidity and mortality. Most patients with IgA nephropathy develop kidney failure in their lifetime, reducing their life expectancy by a decade. Since its first...
Song C Ong,Bruce A Julian
Song C Ong
Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis in many countries. Most patients progress to kidney failure for which kidney transplantation is the optimal therapy. Unfortunately, IgA nephropathy commonly recurs pos...
Updates on IgA Nephropathy [0.03%]
IgA肾病的最新进展
Dana V Rizk
Dana V Rizk
Malak Ghaddar,Mark Canney,Sean J Barbour
Malak Ghaddar
Despite decades of research, our knowledge of the global epidemiology of IgA nephropathy remains limited. Much of what we know about IgA nephropathy incidence comes from biopsy registry studies that are subject to bias related to difference...
Licia Peruzzi,Rosanna Coppo
Licia Peruzzi
IgA nephropathy (IgAN) presents with different expressions and natural histories across ages. The direct comparison of incidence and progression of IgAN in children and adults is difficult due to different policies for performing kidney bio...
The Role of Mucosal Immunity: What Can We Learn From Animal and Human Studies? [0.03%]
黏膜免疫的作用：我们能从动物和人类的研究中学习到什么？
Patrick J Gleeson,Renato C Monteiro
Patrick J Gleeson
Immunoglobulin A (IgA) is a key actor in the mucosal immune system, which moderates interactions between the host and environmental factors such as food antigens and commensal microorganisms. The pathogenesis of IgA nephropathy (IgAN) invol...
Mark Haas
Mark Haas
IgA nephropathy (IgAN), the world's most common form of primary glomerulonephritis (GN), has a variable clinical and pathologic presentation. While all cases of IgAN show dominant or codominant glomerular IgA deposits, their histologic appe...
Evangéline Pillebout
Evangéline Pillebout
IgA vasculitis (IgAV) is considered a systemic form of IgA nephropathy (IgAN). The two diseases share similar geographic and ethnic distribution, along with common variants in genetic association studies. The pathophysiology of IgAN and IgA...
Chee Kay Cheung,Jonathan Barratt
Chee Kay Cheung
The past few years have heralded a sea change in the treatment landscape of IgA nephropathy (IgAN). An increasing understanding of its pathogenesis coupled with favorable changes in the regulatory approval pathway has led to an explosion of...