Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity [0.03%]
定量足细胞尿作为系统性内皮损伤临床标志物的作用：对心血管疾病和长寿的影响
Kamal F Badr
Kamal F Badr
Cardiovascular disease (CVD) remains the leading disability burden and cause of mortality worldwide. As emphasized by the cardiovascular-kidney-metabolic health construct, enhanced screening mechanisms are needed for the identification and ...
Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed? [0.03%]
2025年的肾脏保护策略：还需要肾素-血管紧张素系统抑制剂吗？
Matthew R Weir
Matthew R Weir
The therapeutic advantage of angiotensin-converting enzyme inhibitors was first described more than 40 years ago by Brenner and colleagues. Since then, a number of clinical trials have demonstrated the utility of drugs that modify the renin...
Valerie A Luyckx
Valerie A Luyckx
In 1988, in a seminal paper, Brenner and colleagues proposed that the numbers of nephrons acquired in utero may be a factor that determines an individual's lifelong risk of kidney disease. The hypothesis posited that a kidney with fewer nep...
Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies [0.03%]
慢性肾脏病进展机制：在新型肾脏保护疗法时代的重要性为何如此关键？
Maarten W Taal
Maarten W Taal
Research over several decades has identified multiple factors that contribute to a complex pathway of mechanisms that drive the progression of chronic kidney disease (CKD) across all etiologies. These include glomerular hypertension and hyp...
Maria Castañeda-Bueno,Gerardo Gamba
Maria Castañeda-Bueno
As Director of the Renal Division at Brigham and Women's Hospital, Dr Barry Brenner established a molecular physiology laboratory during the 1980s by recruiting the appropriate researchers, with the vision that cloning the complementary DNA...
The Role of the Epidermal Growth Factor Receptor in Kidney Tubulointerstitial Fibrosis [0.03%]
表皮生长因子受体在肾脏小管间质纤维化中的作用
Raymond C Harris,Ming-Zhi Zhang
Raymond C Harris
Kidney fibrosis is a common cause of chronic kidney disease. Experimental studies have demonstrated a role for the epidermal growth factor receptor (EGFR) signaling pathway in mediating the development and progression of kidney fibrosis. De...
Kidney Transplants From Marginal Donors: From Brenner's Abstract to Double Kidney Transplantation in Humans [0.03%]
边尔论文之后的人类双份边缘供者肾移植
Monica Cortinovis,Norberto Perico,Giuseppe Remuzzi
Monica Cortinovis
"In 1993, based on findings from their experimental studies of kidney mass manipulation in a rat kidney transplant model, Barry Brenner and his colleagues postulated that augmenting the number of viable nephrons in kidney transplantation to...
Tension at the Barrier: Intraglomerular Pressure and the Podocyte Response [0.03%]
podocytes 的压力响应机制：肾小球内压的影响
Martin R Pollak
Martin R Pollak
I synthesize how systemic drivers (hypertension, diabetes, renin-angiotensin-aldosterone system activation) elevate glomerular capillary hydrostatic pressure and cyclic strain and how podocytes sense and respond to these loads via integrins...
Macrophage Plasticity and Functional Dynamics in Acute Kidney Injury and Its Progression to Chronic Kidney Disease [0.03%]
急性肾损伤向慢性肾脏疾病进展过程中巨噬细胞的可塑性和功能动力学
Dana Hammouri,Theresa Weis,Leah J Siskind
Dana Hammouri
Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as interconnected syndromes with overlapping pathophysiological mechanisms. A growing body of evidence suggests that macrophages are central regulators o...
Toward Combinatorial Strategies to Improve Proximal Tubule Recovery Following Acute Kidney Injury [0.03%]
改善急性肾损伤后近端小管恢复的组合策略的研究进展
David A Bastos,Lisa O Oti,Carla L Ellis et al.
David A Bastos et al.
Maintaining kidney health throughout the human lifespan remains a significant global challenge. Worldwide, an estimated 850 million people have some level of kidney disease, with many unaware because of asymptomatic progression. Whether ini...