The Therapeutic Application of Epigenetic Regulation by Natural Herbal Compounds in Kidney Diseases [0.03%]
天然草药化合物表观遗传调控在肾病治疗中的应用
Qiu-Xiang Bai,Kang-Meng Luo,Long-Hao Jia et al.
Qiu-Xiang Bai et al.
Kidney diseases, represented by chronic kidney disease (CKD) and acute kidney injury (AKI), pose significant global public health challenges due to their complex pathogenesis and limited therapeutic options. In recent years, epigenetic regu...
Targeting Cellular Senescence in Kidney Aging with Traditional Chinese Medicine: Potential Senolytic and Senomorphic Strategies [0.03%]
中医药靶向肾脏衰老的细胞衰老：潜在的衰老和形态策略
Jian Li,Yuqing Li,Yuan Liu et al.
Jian Li et al.
Cellular senescence, a key driver of kidney aging and functional decline, manifests in 2 primary forms: (1) replicative senescence, primarily caused by telomere shortening; and (2) stress-induced senescence, triggered by factors such as oxi...
Huong T B Tran,Thang H D Tran,David Harris
Huong T B Tran
Glomerular disease (GD) is common in Vietnam. In the absence of suitable pathology laboratories, well-trained renal pathologists and etiologic laboratory tests, the diagnosis of GD mainly relies on the recognition of clinical syndromes. Sup...
Current Options for Kidney Protection: Are Renin-Angiotensin System Inhibitors Still Relevant? [0.03%]
当前肾脏保护的选项：肾素-血管紧张素系统抑制剂仍然相关吗？
Waichi Wong
Waichi Wong
Chronic kidney disease progresses through convergent mechanisms involving hemodynamic stress, proteinuria, inflammation, fibrosis, and metabolic disturbance. Barry Brenner's hyperfiltration hypothesis established these processes as drivers ...
Proposed Role for Quantitative Podocyturia as a Clinical Marker of Systemic Endothelial Injury: Implications for Cardiovascular Disease and Longevity [0.03%]
定量足细胞尿作为系统性内皮损伤临床标志物的作用：对心血管疾病和长寿的影响
Kamal F Badr
Kamal F Badr
Cardiovascular disease (CVD) remains the leading disability burden and cause of mortality worldwide. As emphasized by the cardiovascular-kidney-metabolic health construct, enhanced screening mechanisms are needed for the identification and ...
Kidney Protection Options in 2025: Are Renin-Angiotensin System Inhibitors Still Needed? [0.03%]
2025年的肾脏保护策略：还需要肾素-血管紧张素系统抑制剂吗？
Matthew R Weir
Matthew R Weir
The therapeutic advantage of angiotensin-converting enzyme inhibitors was first described more than 40 years ago by Brenner and colleagues. Since then, a number of clinical trials have demonstrated the utility of drugs that modify the renin...
Valerie A Luyckx
Valerie A Luyckx
In 1988, in a seminal paper, Brenner and colleagues proposed that the numbers of nephrons acquired in utero may be a factor that determines an individual's lifelong risk of kidney disease. The hypothesis posited that a kidney with fewer nep...
Chronic Kidney Disease Progression Mechanisms: Why They Matter in an Era of Novel Kidney Protective Therapies [0.03%]
慢性肾脏病进展机制：在新型肾脏保护疗法时代的重要性为何如此关键？
Maarten W Taal
Maarten W Taal
Research over several decades has identified multiple factors that contribute to a complex pathway of mechanisms that drive the progression of chronic kidney disease (CKD) across all etiologies. These include glomerular hypertension and hyp...
Maria Castañeda-Bueno,Gerardo Gamba
Maria Castañeda-Bueno
As Director of the Renal Division at Brigham and Women's Hospital, Dr Barry Brenner established a molecular physiology laboratory during the 1980s by recruiting the appropriate researchers, with the vision that cloning the complementary DNA...
The Role of the Epidermal Growth Factor Receptor in Kidney Tubulointerstitial Fibrosis [0.03%]
表皮生长因子受体在肾脏小管间质纤维化中的作用
Raymond C Harris,Ming-Zhi Zhang
Raymond C Harris
Kidney fibrosis is a common cause of chronic kidney disease. Experimental studies have demonstrated a role for the epidermal growth factor receptor (EGFR) signaling pathway in mediating the development and progression of kidney fibrosis. De...