Challenges in Spatial Metabolomics and Proteomics for Functional Tissue Unit and Single-Cell Resolution [0.03%]
功能组织单位和单细胞分辨率的空间代谢组学和蛋白质组学面临的挑战
Kevin J Zemaitis,Ljiliana Paša-Tolić
Kevin J Zemaitis
In the last decade, advanced developments of mass spectrometry-based assays have made spatial measurements of hundreds of metabolites and thousands of proteins not only possible, but routine. The information obtained from such mass spectrom...
Kyle A Vanderschoot,Kayle J Bender,Christopher M De Caro et al.
Kyle A Vanderschoot et al.
In the era of precision medicine, scientists are creating atlases of the human body to map cells at the molecular level, providing insight into what fundamentally makes each cell different. In these atlas efforts, multimodal imaging techniq...
Brittney L Gorman,Jessica K Lukowski
Brittney L Gorman
Kidney disease is a global health issue that affects over 850 million people, and early detection is key to preventing severe disease and complications. Kidney diseases are associated with complex and dysregulation of lipid metabolism. Spat...
Guanshi Zhang,W Brian Reeves
Guanshi Zhang
Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention, and effective therapeutic management o...
Multi-Omics Integration in Nephrology: Advances, Challenges, and Future Directions [0.03%]
肾脏病学中的多组学整合：进展、挑战与未来方向
Afaf Saliba,Yuheng Du,Tianqing Feng et al.
Afaf Saliba et al.
Omics technologies have transformed nephrology, providing deep insights into molecular mechanisms of kidney disease and enabling more precise diagnostic tools, therapeutic strategies, and prognostic markers. Multi-omics data integration, sp...
Dušan Veličković,Christopher R Anderton
Dušan Veličković
Glycans are critical for the kidney's physiological and pathological cellular functions, and our ability to see their spatial distributions within tissues has helped us reveal how these carbohydrate moieties are involved in many of these pr...
Kumar Sharma,Ravi Iyengar
Kumar Sharma
Integrating Metabolomics and Transcriptomics to Characterize Differential Functional Capabilities of Kidney Proximal Tubule Cell Subtypes [0.03%]
整合代谢组学和转录组学以表征肾脏近端小管细胞亚型的功能差异
Jens Hansen,Mustafa M Siddiq,John Cijiang He et al.
Jens Hansen et al.
The coupling between energy metabolism and transport processes is a key feature that defines the functional capability of proximal tubule cells. Recent studies using metabolomics and transcriptomics provide insights into the relationships b...
The Journey to Advocacy: Celebrating the IgA Nephropathy Foundation's 20th Anniversary [0.03%]
倡导之旅：庆祝IgA肾病基金会成立20周年
Brian Parlato
Brian Parlato
The IgA Nephropathy Foundation was established in 2004 by Bonnie and Ed Schneider, the concerned parents of a young boy diagnosed with IgA nephropathy (IgAN). At the time the Foundation was established, patients had trouble finding the most...
Fahmeedah Kamal,Jackson Kim,Richard Lafayette
Fahmeedah Kamal
IgA nephropathy (IgAN) is the most prevalent primary glomerular disease and has been recognized to carry a poor prognosis. It is therefore critical to identify the patients that will progress to ESKD and start treatments early. The current ...