Yohan Park,Kurt A Zimmerman,Sarah J Miller
Yohan Park
Acute kidney injury (AKI) is a serious and common clinical condition characterized by a sudden decline in kidney function. Although kidney function decline is typically reversible, a certain subset of AKI patients eventually develop chronic...
The Clinical View of Sepsis-Associated AKI: How Basic Science Can Help Solve This Problem [0.03%]
脓毒症相关性急性肾损伤的临床研究及基础医学解决方案
James D Odum,Denise C Hasson,Natalja L Stanski et al.
James D Odum et al.
The global health impact of sepsis is difficult to understate. As a complication of sepsis, the development of sepsis-associated acute kidney injury (SA-AKI) significantly increases the risk of mortality. Although several epidemiological ri...
Kevin G Burfeind,Daiki Aomura,Jessica F Hebert et al.
Kevin G Burfeind et al.
Acute cardiorenal syndrome (cardiorenal syndrome type 1, CRS1) is a common complication of the most common cause of death, cardiovascular disease, and therefore is of considerable importance. Foundational research over the last 100 years de...
A Holistic Approach to AKI: Integrating Clinical and Molecular Data in the Human Kidney [0.03%]
全面看待AKI：在人体肾脏中整合临床和分子数据
Jennifer A Schaub,Mathew Alaba,Matthias Kretzler
Jennifer A Schaub
Despite intensive research efforts, acute kidney injury (AKI) is a common clinical syndrome that has limited treatment options apart from supportive care. The increasing availability of molecular interrogation data from patients with Acute ...
High Environmental Heat Exposure Is a Risk Factor for Acute Kidney Injury and Chronic Kidney Disease [0.03%]
高温暴露是急性肾损伤和慢性肾脏病的风险因素
Hung Nguyen,Bryan K Becker,Subhashini Bolisetty et al.
Hung Nguyen et al.
Chronic kidney disease of unknown etiology has been reported in Mesoamerican regions and other parts of the world, with increasing evidence pointing to heat stress as a central contributing factor. The incidence of acute kidney injury appea...
Introduction: The 2025 American Society of Nephrology Third Acute Kidney Injury: Bench to Bedside Conference [0.03%]
序章：美国肾脏病学会第3届急性肾损伤会议（从实验研究到临床应用）
Kelly A Hyndman,Leah J Siskind,Mark de Caestecker
Kelly A Hyndman
Regenerative Versus Nonregenerative Repair of the Renal Medulla After Reversal of Ureteral Obstruction [0.03%]
尿路梗阻解除后的肾髓质修复：再生和非再生反应
Alex Gonzalez,Rachel Delgado,Mark P de Caestecker
Alex Gonzalez
Many patients with urinary obstruction have an accelerated decline in renal function despite early urologic interventions. They also have defects in urinary concentrating capacity that may predispose them to acute kidney injury and chronic ...
Complexities in Variant Analysis, Classification, and Interpretation in Kidney Disease-Related Genes [0.03%]
肾脏疾病相关基因变异分析、分类和解读的复杂性
Maggie Westemeyer,Michelle S Bloom,Alicia B Byrne et al.
Maggie Westemeyer et al.
Advancements in chronic kidney disease (CKD) genetic research and next-generation sequencing have improved CKD diagnosis and personalized treatment. Broad gene panel testing or whole exome/genome sequencing has greatly improved understandin...
Integration of Genetics Into the Design and Conduct of Clinical Trials in Nephrology [0.03%]
遗传学在肾脏病临床试验设计和实施中的应用整合
Justyna E Ozimek-Kulik,Nicholas G Larkins,Gopi K Rangan et al.
Justyna E Ozimek-Kulik et al.
Advances in genomic diagnostics have enabled earlier and more precise identification of genetic kidney disease, but the translation of these insights into trial methodology and therapeutic development has lagged. This review examines the cu...
Janewit Wongboonsin,Andrew J Mallett
Janewit Wongboonsin