Kidney Transplants From Marginal Donors: From Brenner's Abstract to Double Kidney Transplantation in Humans [0.03%]
边尔论文之后的人类双份边缘供者肾移植
Monica Cortinovis,Norberto Perico,Giuseppe Remuzzi
Monica Cortinovis
"In 1993, based on findings from their experimental studies of kidney mass manipulation in a rat kidney transplant model, Barry Brenner and his colleagues postulated that augmenting the number of viable nephrons in kidney transplantation to...
Tension at the Barrier: Intraglomerular Pressure and the Podocyte Response [0.03%]
podocytes 的压力响应机制：肾小球内压的影响
Martin R Pollak
Martin R Pollak
I synthesize how systemic drivers (hypertension, diabetes, renin-angiotensin-aldosterone system activation) elevate glomerular capillary hydrostatic pressure and cyclic strain and how podocytes sense and respond to these loads via integrins...
Macrophage Plasticity and Functional Dynamics in Acute Kidney Injury and Its Progression to Chronic Kidney Disease [0.03%]
急性肾损伤向慢性肾脏疾病进展过程中巨噬细胞的可塑性和功能动力学
Dana Hammouri,Theresa Weis,Leah J Siskind
Dana Hammouri
Acute kidney injury (AKI) and chronic kidney disease (CKD) are increasingly recognized as interconnected syndromes with overlapping pathophysiological mechanisms. A growing body of evidence suggests that macrophages are central regulators o...
Toward Combinatorial Strategies to Improve Proximal Tubule Recovery Following Acute Kidney Injury [0.03%]
改善急性肾损伤后近端小管恢复的组合策略的研究进展
David A Bastos,Lisa O Oti,Carla L Ellis et al.
David A Bastos et al.
Maintaining kidney health throughout the human lifespan remains a significant global challenge. Worldwide, an estimated 850 million people have some level of kidney disease, with many unaware because of asymptomatic progression. Whether ini...
Madhumitha Rajagopal,Lili Chan,Girish N Nadkarni
Madhumitha Rajagopal
Acute kidney injury (AKI), a drop in kidney function with multiple etiologies, is a common complication in hospitalized patients and is associated with poorer patient outcomes. With the advent of electronic health records, machine learning ...
Neuroimmune Regulation for Acute Kidney Injury Therapy: Insights Along the Path From Bench to Bedside [0.03%]
从实验台到病床：急性肾损伤治疗中神经免疫调节的启示路径
William T Nash,Mark D Okusa
William T Nash
Over the past 25 years, neuroimmune regulation has emerged as a compelling approach to the prevention and treatment of acute kidney injury. Vagus nerve stimulation through the cholinergic anti-inflammatory pathway can suppress inflammatory ...
Innovative Technologies for Kidney Research: Three-Dimensional Imaging and Quantification [0.03%]
肾脏研究的创新技术：三维成像和定量分析新技术
Sarah R McLarnon,Pierre-Emmanuel Y N&#x;Guetta,Lori L O&#x;Brien
Sarah R McLarnon
Image analysis has played a critical role in our understanding of kidney morphology, function, and disease. This analysis has been historically limited to visualizing defined regions within the kidney in two dimensions. However, in recent y...
David M Burmeister,Julia N Nguyen,Ian J Stewart
David M Burmeister
Acute kidney injury (AKI) is a relatively common complication of trauma and is associated with significant morbidity and mortality in clinical studies. Given logistical and cost constraints, the majority of animal research on trauma-induced...
Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury [0.03%]
线粒体疗法在急性肾损伤治疗中的应用
Prisha S Patel,Navjot S Pabla,Amandeep Bajwa
Prisha S Patel
Acute kidney injury (AKI) continues to pose a significant clinical burden, characterized by high morbidity and mortality rates. Emerging evidence has established mitochondrial dysfunction as a central driver in the pathogenesis of AKI, enco...
Nontraditional Models for Acute Kidney Injury Research: Organoids, Zebrafish, and More [0.03%]
非传统模型在急性肾损伤研究中的应用：类器官、斑马鱼及其他
Eeshrita Jog,Tongyu Wu,Joseph C Maggiore et al.
Eeshrita Jog et al.
Acute kidney injury (AKI) is a condition that is associated with increased mortality in the clinic and currently has no Food and Drug Administration-approved drug intervention that prevents progression to chronic kidney disease. To address ...