Anna M Firshman,Stephanie J Valberg
Anna M Firshman
Type 1 Polysaccharide Storage Myopathy (PSSM1) is an autosomal dominant glycogen storage disorder affecting more than 20 breeds of horses that can present with a variety of signs, including exertional rhabdomyolysis (ER). It is diagnosed by...
Stephanie J Valberg
Stephanie J Valberg
Although horses most commonly develop exertional rhabdomyolysis, there are numerous causes for nonexertional rhabdomyolysis (nonER) that pose a serious health threat to horses. Their etiologies can be broadly categorized as toxic, genetic, ...
Carrie J Finno,Erica McKenzie
Carrie J Finno
Nutritional deficiencies of vitamin E and selenium can occur alone or concurrently. Prolonged and sustained deficiency of either or both nutrients can lead to profound clinical disease. Selenium deficiency can also result in signs of cardia...
Erica McKenzie
Erica McKenzie
The equine muscle system is complex and prone to a large range of hereditary and acquired diseases that often have overlapping clinical signs with orthopedic, neurologic, and other disorders. Obtaining a clinical history that fully outlines...
Stephanie J Valberg
Stephanie J Valberg
Horses are particularly susceptible to developing exertional rhabdomyolysis (ER) characterized by muscle stiffness, pain, and reluctance to move. Diagnosis requires establishing abnormal increases in serum creatine kinase activity when hors...
Sian A Durward-Akhurst,Stephanie J Valberg
Sian A Durward-Akhurst
Several inflammatory myopathies have an infectious or immune-mediated basis in the horse. Myosin heavy chain myopathy is caused by a codominant missense variant in MYH1 and has 3 clinical presentations: immune-mediated myositis, calciphylax...
Monica Aleman
Monica Aleman
Muscle disease has various clinical manifestations that range from exertional and non-exertional rhabdomyolysis, fasciculations, weakness, rigidity, stiffness, gait abnormalities, poor performance, and alterations in muscle mass and tone. N...
Genetics of Muscle Disease [0.03%]
肌肉疾病的遗传学
Carrie J Finno
Carrie J Finno
In the field of equine muscle disorders, many conditions have a genetic basis. Therefore, genetic testing is an important part of the diagnostic evaluation. Validated genetic tests are currently available for 5 equine muscle disorders: hype...
Myofibrillar Myopathy [0.03%]
肌原纤维肌病
Stephanie J Valberg,Zoë J Williams
Stephanie J Valberg
Myofibrillar myopathy (MFM) is characterized by segmental disarray of myofibrils and ectopic accumulation of a protein called desmin. Previously thought to be a glycogen storage disease, MFM is now recognized as a stand-alone myopathy. Endu...
Joe D Pagan,Stephanie J Valberg
Joe D Pagan
Many myopathies in horses can be managed by exercise regimes and dietary modifications. This includes modifying the amount of nonstructural carbohydrate, fat, amino acids, vitamin E, and selenium based on the horse's specific myopathy, meta...