From Screening to Decision: The Current Landscape of Localized Prostate Cancer Management [0.03%]
从筛查到决策：局灶性前列腺癌的当前治疗格局
Hanan Goldberg,Gennady Bratslavsky
Hanan Goldberg
Kevin R Loughlin
Kevin R Loughlin
Laurence Klotz
Laurence Klotz
Active surveillance (AS), first described as a management strategy for favorable risk prostate cancer more than 20 years ago has now been widely adopted as the treatment of choice for these patients. AS surveillance initially consisted of r...
Gleason Grade Group 1 Prostate Cancer: Arguments for and Against a Cancer Designation [0.03%]
Gleason 1级前列腺癌：是否应被定义为癌症的争论
Christopher P Dall,Michelle S Hirsch,Adam S Kibel et al.
Christopher P Dall et al.
One of the critical challenges in managing localized prostate cancer is in balancing the need for appropriate treatment of aggressive disease while avoiding overtreatment of indolent cases. Gleason Grade Group 1 prostate adenocarcinoma has ...
Should Gleason 6 Still Be Considered Cancer? A Narrative Review of its Biology and Clinical Course, with Implications for Guideline Recommendations and Practice Implementation [0.03%]
葛莱森六级前列腺癌是否应划分为癌症？其生物学和临床过程的文献回顾及其对指南建议和实践应用的影响
Bowen Yao,Timothy Wilt,Philipp Dahm
Bowen Yao
Gleason 6 prostate cancer, also classified as grade group 1 (GG1), demonstrates exceptionally indolent behavior with minimal risk of metastasis or mortality. Despite this, its designation as cancer drives overdiagnosis, overtreatment, and p...
Arman S Walia,William Huang
Arman S Walia
The detection of localized prostate cancer has transformed tremendously in the twenty-first century with the emergence of more accurate imaging technologies. The standard transrectal ultrasound is now supported by the widespread adoption of...
Rebecca A Sager,Gennady Bratslavsky
Rebecca A Sager
Genetic testing is increasingly central to the management of localized prostate cancer (PCa). Advances in next-generation sequencing have revealed both germline and somatic alterations that influence disease risk, prognosis, and therapeutic...
John Hanna,Gennady Bratslavsky,Liang Cheng et al.
John Hanna et al.
Recent changes in grading guidelines include the adoption of grade groups, reporting of percentage of pattern 4, reporting of intraductal carcinoma, and presence of cribriform pattern, making pathology reports more prognostically accurate a...
Advances in Prostate Biopsy [0.03%]
前列腺活检的新进展
Jillian M Egan Kelly,Badar M Mian
Jillian M Egan Kelly
The ultrasound-guided, transrectal, sextant prostate biopsy procedure has undergone numerous modifications to improve its diagnostic yield and safety. Biopsy templates evolved from six to as many as twenty-four samples, with the 10-12 core ...
Landan P MacDonald,Andrew M Fang,Chad Tang et al.
Landan P MacDonald et al.
The diagnosis and management of localized prostate cancer (PCa) remains an active field of research, with many recently published and upcoming clinical trials. Advances in local therapy, management of pelvic lymph nodes, imaging, systemic t...