Mathew H Chung
Mathew H Chung
Paul J Schenarts
Paul J Schenarts
Pediatric Solid Tumors: Genetics and Screening, Prevention, and Treatment of the General Surgeon [0.03%]
儿科实体瘤：普通外科医生的遗传学和筛查、预防及治疗
Laritza Diaz,Elisabeth T Tracy
Laritza Diaz
Cancer predisposition syndromes (CPS) account for an estimated 8% to 15% of pediatric malignancies. For surgeons taking care of children, adolescents, or young adults with childhood cancers, familiarity with these syndromes is essential. Re...
Matthew Steensma
Matthew Steensma
Sarcoma genetics carries important clinical implications for the screening, diagnosis, and management of patients and their families. However, most sarcomas develop sporadically. Management of patients with hereditary sarcoma syndromes is c...
Joseph G R Partuzo,Belén Mora-Garijo,Jonathan Hwang
Joseph G R Partuzo
Prostate cancer is a highly prevalent and heritable malignancy with marked disparities in incidence, stage at diagnosis, and mortality among minority populations. While localized disease carries an excellent prognosis, outcomes decline shar...
Corbyn M Nchako,Kara C Long,Ying L Liu et al.
Corbyn M Nchako et al.
Advances in cancer genomics have transformed the prevention, classification, and management of gynecologic malignancies. Germline and somatic genetic alterations now inform hereditary cancer risk assessment, molecular tumor classification, ...
Shannon M Smith,G Paul Wright
Shannon M Smith
Malignant melanoma represents a lethal cutaneous malignancy. This review article highlights somatic mutations as well as high- and moderate-penetrance germline genetic mutations frequently found in melanoma. BRAF and CDKN2A remain the most ...
The Genetics and Screening of Gastroenteropancreatic Neuroendocrine Tumors and Adrenal Tumors [0.03%]
胃肠道胰神经内分泌肿瘤和肾上腺肿瘤的遗传学及筛查
William Wong,Sofia W Viana,Mecker G Möller
William Wong
Management of adrenal tumors and neuroendocrine tumors (NETs) requires careful discussion on whether resection with curative intent is worth the risk of surgical morbidity and risk of endocrine morbidity requiring exogenous hormonal replace...
Sami O Abul-Khoudoud,Jeffrey M Hardacre
Sami O Abul-Khoudoud
Pancreatic cancer is a highly lethal malignancy with an overall 5-year survival rate of just 13%, and its most common histologic subtype, pancreatic ductal adenocarcinoma (PDAC), carries an even poorer prognosis. Its aggressive nature is dr...
Role of Genetics in Gastric Malignancy: Screening, Prevention and Treatment [0.03%]
遗传学在胃恶性肿瘤筛查、预防和治疗中的作用
Rui Zheng-Pywell,Perry Shen
Rui Zheng-Pywell
There are 3 known hereditary gastric cancers that contribute to 1% to 3% of all gastric malignancies: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastric cancer. A...