Time-restricted feeding rescues sociability deficits and reduces neuroinflammation in aged mice [0.03%]
限时进食可缓解老年小鼠的社会行为缺陷并减少神经炎症
Louise M Ince,Brandy N Routh,Jeffrey S Darling et al.
Louise M Ince et al.
The aging brain exhibits an increased inflammatory potential which in turn elicits behavioral changes e.g., social withdrawal. Social isolation is a risk factor for additional health complications, and interventions which can mitigate these...
Lysophosphatidic acid derivative is a novel candidate of therapeutic agents for a mouse model of frontotemporal dementia with progranulin deficiency [0.03%]
磷脂酸衍生物是突变性前粒蛋白缺乏型额颞痴呆小鼠模型的潜在治疗药物候选物
Nami Yamamoto,Rino Takei,Mari Gotoh et al.
Nami Yamamoto et al.
Frontotemporal dementia (FTD) is driven by progranulin haploinsufficiency, in which age-dependent microglial activation promotes neurodegeneration through TDP-43 proteinopathy. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediat...
Childhood maltreatment alters associations between age and neurocognitive health metrics in community-dwelling adults [0.03%]
儿童虐待会改变社区居住成年人年龄与神经认知健康指标之间的关系
Anna D Stumps,Nadia Bounoua,Naomi Sadeh
Anna D Stumps
To further understand whether childhood maltreatment (CM) is associated with indicators of accelerated cognitive aging, this study investigated whether CM moderated the relationship of age with gray matter volume (GMV) and executive functio...
1H-MR spectroscopy biomarkers are associated with plasma-derived biomarkers of amyloid-β and tau in the early phase of AD continuum [0.03%]
在AD病程早期阶段，1H-MRS生物标志物与血浆来源的淀粉样蛋白-β和tau生物标志物相关性研究
Firat Kara,James M Joers,Scott A Przybelski et al.
Firat Kara et al.
The objective of the study was to evaluate the relationship of plasma biomarkers of Alzheimer's disease (AD) with in vivo proton magnetic resonance spectroscopy (¹H-MRS) markers, and their association with cognitive function across the ear...
Depressive symptoms and plasma AT(N) biomarkers among cognitively healthy and mild cognitively impaired in a diverse cohort [0.03%]
抑郁症状与认知健康和轻度认知障碍人群血浆AT(N)生物标志物之间的关系：多样化的队列研究
Christina S Dintica,Leigh Johnson,Melissa Petersen et al.
Christina S Dintica et al.
Depression is a known risk factor for dementia and MCI, but its associations with AT(N) biomarkers remain inconsistent and may differ by cognitive status. We cross-sectionally studied 2929 dementia-free participants from the Health & Aging ...
Optimized atlas for early tau-PET staging via native space segmentations [0.03%]
基于原空间分割的Tau-PET早期阶段优化图谱
Etienne Aumont,Brandon J Hall,Tevy Chan et al.
Etienne Aumont et al.
Positron Emission Tomography (PET) early Braak staging might be susceptible to anatomical variability and atrophy in the medial temporal lobe (MTL) structures. These factors should be accounted for in an optimized atlas to improve staging a...
EEG slow waves and cognitive decline in Isolated Rapid Eye Movements Behavior Disorder: A multicenter longitudinal study [0.03%]
孤立性快速眼动睡眠行为障碍中脑电图慢波和认知衰退的多中心纵向研究
Caterina Leitner,Dario Arnaldi,Francesca Casoni et al.
Caterina Leitner et al.
This multicenter retrospective longitudinal study aims to evaluate the association between electroencephalographic slow oscillations (0.3-1 Hz) and slow waves (1-4 Hz) with cognitive performance, and their impact on phenoconversion in patie...
Targeting neuronal activity and neuroinflammation for the treatment of Alzheimer's disease in a mouse model [0.03%]
阿尔茨海默病小鼠模型的神经元活动和神经炎症治疗靶点
Chongzhen Yuan,Long Li,Hsiao-Yun Lin et al.
Chongzhen Yuan et al.
Alzheimer's disease (AD) is characterized by progressive cognitive decline driven by complex pathological processes, including tau hyperphosphorylation (p-Tau), amyloid-beta (Aβ) accumulation, and neuroinflammation. In this study, we inves...
Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition [0.03%]
年龄相关的听神经缺陷会传播中枢增益：与皮层微结构和言语理解的关系在整个听觉系统中的传播
Emily M Fabrizio-Stover,James W Dias,Carolyn M McClaskey et al.
Emily M Fabrizio-Stover et al.
There is growing evidence that perceptual difficulties associated with age-related hearing loss are not solely due to cochlear damage and are exacerbated by central nervous system changes. We examined electrophysiological (EEG) responses to...
Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer's continuum [0.03%]
海马1H-磁共振波谱代谢物与认知正常老年人脑脊液tau病理异常沿阿尔茨海默病病程的变化相关性研究
Jessica N Lingad,Casey R Vanderlip,Sierra Wright et al.
Jessica N Lingad et al.
Relationships between Alzheimer's disease (AD) pathologies in cognitively unimpaired adults and in vivo neurometabolic properties measured directly from the hippocampus, a vulnerable region early along the AD continuum, are not well-underst...