A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease [0.03%]
阿尔茨海默病小鼠模型中ipRGCs的结构和功能后果的时间线
Brandy S Recio,William A Pérez,Ruth Tjondropurnomo et al.
Brandy S Recio et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognitive, sensory and motor systems, including the visual system and has a significant impact on autonomy and quality of life. Emerging evidence suggests tha...
Rare ABCA7 mutations in Alzheimer's disease and cerebral amyloid angiopathy pathology [0.03%]
ABCA7罕见变异在阿尔茨海默病及脑淀粉样血管病中的研究
Elisabeth Hendrickx Van de Craen,Liene Bossaerts,Anne Sieben et al.
Elisabeth Hendrickx Van de Craen et al.
Rare mutations in the ATP binding cassette subfamily A member 7 (ABCA7) gene are known risk factors for Alzheimer's disease (AD). Genetic sequencing in 1372 Belgian patients previously revealed rare ABCA7 mutations in 102 carriers, 58 with ...
Regional growth rates of white matter hyperintensities are associated with beta-amyloid burden [0.03%]
白质高信号的增长率与β淀粉样蛋白负担相关
Jeremy F Strain,Maryam Rahmani,Chia-Ling Phuah et al.
Jeremy F Strain et al.
There is increasing evidence for an association between white matter hyperintensities (WMH) and brain beta-amyloid deposition. How WMH are longitudinally associated with brain beta-amyloid burden requires further investigation, particularly...
Resting-state EEG aperiodic exponent moderates the association between age and memory performance in older adults [0.03%]
年龄与记忆表现在老年人大肠埃氏菌休息状态下的非周期指数的调节作用
Alicia J Campbell,Toomas Erik Anijärv,Mikael Johansson et al.
Alicia J Campbell et al.
Memory functions are susceptible to age-related cognitive decline, making it essential to explore the underlying neurophysiological mechanisms that contribute to memory function during healthy ageing. Resting-state EEG (rsEEG) parameters, p...
Cognitive reserve is associated with less cognitive decline from white matter hyperintensities [0.03%]
认知储备与由高信号白质体积变化引起的认知下降较小有关
Arthur P Hamilton,Kaiah N Sotebeer,John G Grundy et al.
Arthur P Hamilton et al.
Previous research examining the contribution of white matter hyperintensities (WMHs) to cognitive decline has focused on overall lesion burden. A new approach, afforded by the Lesion Quantification Toolkit (LQT), measures localized connecti...
PS19 mouse tauopathy is associated with sex-dependent sleep loss and hyperarousal, and predicts cognitive performance [0.03%]
PS19小鼠tauopathies与性别相关的睡眠丧失和过度唤起相关，并预测认知表现
Jarrah O Z J Kron,Jeremy A Metha,Heather J Daykin et al.
Jarrah O Z J Kron et al.
Alzheimer's disease (AD) is a major public health concern in societies with increasingly ageing populations. Accumulating evidence implies a specific link between the development of tauopathy, cognitive impairment, and sleep loss in AD pati...
Diagnostic performance of plasma pTau217/Aβ42 ratio and a three-zone threshold model for Alzheimer's disease [0.03%]
血浆pTau217/Aβ42比值及三区阈值模型在阿尔茨海默病中的诊断价值研究
Alberto Benussi,Marco Michelutti,Tiziana Maria Isabella Lombardo et al.
Alberto Benussi et al.
Early and accurate diagnosis of Alzheimer's disease (AD) typically relies on invasive or expensive methods like cerebrospinal fluid (CSF) biomarkers and amyloid PET imaging. Blood-based biomarkers, particularly plasma phosphorylated tau (pT...
Excess iron may accelerate amyloid beta accumulation in the brains of older mice [0.03%]
过量铁元素或可加速年老小鼠脑部淀粉样蛋白β的积累
Soo-Jin Song,Jung-A Shin
Soo-Jin Song
Aging is a natural physiological process that may be accompanied by pathological changes, particularly in the brain. Iron is an essential trace element supporting various physiological functions and maintaining cellular homeostasis. However...
Ahmed A Bahrani,Peter T Nelson,Erin L Abner et al.
Ahmed A Bahrani et al.
White matter hyperintensities (WMH) are an MRI-based biomarker associated with aging, Alzheimer's disease, and vascular dementia. Although the volume of WMH typically increases over time (growth) for individuals, WMH volume in some cases ca...
Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults [0.03%]
老龄人群蓝斑-去甲肾上腺素系统张力性高活化的脑电、瞳孔和行为学证据
Andy Jeesu Kim,Santiago Morales,Joshua Senior et al.
Andy Jeesu Kim et al.
Neuroimaging studies have shown that age-related dysregulation of the locus coeruleus-noradrenaline (LC-NA) system is associated with cognitive decline. However, due to limitations in directly measuring LC function in vivo, it remains uncle...