Gender-related facilitators and barriers to participation in research on aging using fuzzy cognitive mapping [0.03%]
运用模糊认知图法进行老年学研究的相关性别因素及障碍研究
Vasvi Dhir,Ivan Sarmiento,Isabel McDonald et al.
Vasvi Dhir et al.
In the context of cognitive neuroscience research on aging, older women are often overrepresented in observational research, whereas men are overrepresented in clinical trials. Factors underlying the selection bias between and across gender...
Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils [0.03%]
年轻和年老仓鼠前庭感觉上皮中钙结合蛋白标记的传入终端定量
Anna Dondzillo,Tyler Bauer,Kathryn King et al.
Anna Dondzillo et al.
Vestibular dysfunction becomes increasingly prevalent with aging and it is estimated that more than 80 % of people over 80 years old experience balance problems linked to vestibular dysfunction. Within the peripheral vestibular organs, sens...
ABCA7 rs115550680 risk allele carriers have lower medial temporal lobe dynamic network flexibility than APOE-ε4 allele carriers among older African Americans [0.03%]
在老年非裔美国人中，与APOE-ε4等位基因携带者相比，ABCA7 rs115550680风险等位基因的携带者的海马动态网络灵活性更低
Miray Budak,Bernadette A Fausto,Victoria Paruzel et al.
Miray Budak et al.
Alzheimer's disease (AD) pathology disrupts functional brain connectivity long before symptoms emerge. African Americans face elevated AD risk, yet underlying mechanisms remain unclear. Genetic risk differs by ancestry: APOE-ε4 strongly pr...
Human in vitro and rodent in vivo models highlight progressive mitochondrial dysfunction as a starting point of cerebral amyloidosis [0.03%]
人體外和rodent体内的模型强调渐进的线粒体功能障碍作为脑淀粉样病变的起点
Zahra Motamed,Gisela Novack,Daniel Heutschi et al.
Zahra Motamed et al.
Mitochondrial dysfunction is a well-established hallmark of Alzheimer's disease (AD), particularly in the context of amyloid-beta (Aβ) accumulation. Here, we explored the progression of mitochondrial impairment associated with cerebral amy...
Frontal white matter hyperintensity burden predicts cognitive response to N-acetylcysteine and exercise in vascular mild cognitive impairment [0.03%]
frontal白质高信号负荷可预测血管性轻度认知障碍患者用N-乙酰半胱氨酸和运动治疗的认知反应
Ethan Mah,Damien Gallagher,Fuqiang Gao et al.
Ethan Mah et al.
Vascular mild cognitive impairment (vaMCI) is a prodromal stage of dementia defined by cognitive deficits due to cerebrovascular disease. Increased white matter hyperintensity (WMH) volume has been associated with reduced executive function...
Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults [0.03%]
基于活动记录仪的体力活动变化与老年人认知衰老之间的并行关联
Ranjani P Shankar,Rowan Saloner,Coty Chen et al.
Ranjani P Shankar et al.
Physical activity (PA) is associated with lower dementia risk, yet few studies examine objectively measured PA with concurrently measured brain and cognitive aging outcomes longitudinally, leaving a gap in knowledge regarding temporality of...
Maddison L Hodgins,Selena P Maxwell,Susan E Howlett et al.
Maddison L Hodgins et al.
Frailty increasingly is recognized as a factor that modifies the relationship between disease biomarkers, including neuropathology, and dementia expression. The mechanisms underlying the relationship between frailty and dementia remain uncl...
Alpha band activity mediates age-related effects on three distinct aspects of working memory dynamics [0.03%]
阿尔法波活动调节年龄相关的三种工作记忆动态效应
Charlotte Pscherer,Moritz Mückschel,Christian Beste
Charlotte Pscherer
Working memory (WM) processes decline with increasing age. According to recent concepts, it is necessary to differentiate between dynamically changing 'WM states' which are regulated via gating mechanisms. We investigated which neural oscil...
Investigating dual-task biomarkers of subjective cognitive decline using functional near-infrared spectroscopy [0.03%]
利用功能近红外光谱法研究主观认知下降的双任务生物标志物
Talia Salzman,Diana P Tobón,Vanessa Taler et al.
Talia Salzman et al.
Older adults with subjective cognitive decline (SCD) may be at a greater risk of cognitive impairment than older adults without SCD (i.e., non-SCD). This study examined dual-task changes in cerebral oxygenation and performance to determine ...
Neuronal TrkB supports adult cortical oligodendrogenesis in the brains of older adult mice [0.03%]
成人脑中神经元TrkB支持老年小鼠皮层少突胶质细胞生成
Madeline Nicholson,Rhiannon J Wood,Simon S Murray et al.
Madeline Nicholson et al.
Lifelong oligodendrogenesis and myelination is critical for healthy brain aging. Using cumulative labelling with thymidine analogue, 5-ethynyl-2'-deoxyuridine (EdU) for 6-weeks commencing at 2-, 12- and 18-months of age in C57BL/6 mice, we ...