An exploratory analysis of plasma biomarkers associated with cerebral amyloid angiopathy [0.03%]
血浆生物标志物与脑淀粉样血管病相关性的探索性分析
Ersin Ersözlü,François Meyer,Lukas Preis et al.
Ersin Ersözlü et al.
Cerebral amyloid angiopathy (CAA) remains diagnostically challenging, particularly in asymptomatic individuals. While CAA often co-exists with Alzheimer's disease (AD), it may even have a direct impact on AD pathophysiology and the cognitiv...
Cardiovascular imaging reveals pathways linking cardiovascular risk factors to brain aging and cognition [0.03%]
心血管影像揭示了心血管风险因素与大脑衰老和认知之间的联系的途径
Yalda Amirmoezzi,Vanessa Cropley,Andrew Zalesky et al.
Yalda Amirmoezzi et al.
Cardiovascular risk (CVR) factors exert effects that extend beyond the vascular system, influencing brain structure, neural function, and cognitive performance. The mechanisms by which CVR factors exert these effects remain unclear. Here, w...
Altered theta distribution and coherence during set-shifting in older age [0.03%]
老化过程中在集合转换时theta频段分布和一致性的改变
Margarita Darna,Anni Richter,Jens-Max Hopf et al.
Margarita Darna et al.
Cognitive flexibility is an executive function that enables adapting behaviour to a changing environment and is thus critical for daily life. The degree of its preservation upon healthy aging and the neural mechanisms underlying it are stil...
Age-related differences in memory encoding as a function of pupillary dynamics [0.03%]
与瞳孔动态功能相关的年龄差异记忆编码
Adrian Ruiz Chiapello,Enzo Buscato,Muriel Mescam et al.
Adrian Ruiz Chiapello et al.
Pupillary dynamics are known to depend on tonic and phasic activity of the brainstem locus coeruleus (LC), a key neuromodulatory nucleus. The LC shows a decline in its structural integrity in older age that likely impacts long-term memory. ...
Rachel Bercovitch,Earvin S Tio,Rajith Wickramatunga et al.
Rachel Bercovitch et al.
Hand grip strength (HGS) is a predictor of cognitive decline in aging. To understand the direct and indirect mechanisms underlying this association, we performed integrative analyses of genetic, cognitive, and autopsy data. A polygenic risk...
Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer's disease [0.03%]
血浆胶质纤维酸性蛋白和APOE-ε4与阿尔茨海默病的关系
Yalin Zhu,Guoyu Lan,Anqi Li et al.
Yalin Zhu et al.
Both Apolipoprotein E-ε4 (APOE-ε4) and astrocytic activation, as measured by glial fibrillary acidic protein (GFAP), play critical roles in Alzheimer's disease (AD). However, the influence of astrocytic activation on the relationship betw...
Effector-specific corticospinal modulation is preserved in older adults during proactive stopping: A novel Bayesian approach [0.03%]
老年人在主动性停止期间效应器特异性皮质脊髓调节得以保持：一种新的贝叶斯方法
Sarah A Kemp,Niek Stevenson,Rohan Puri et al.
Sarah A Kemp et al.
Action cancellation declines with age, contributing to impairments in executive function and overall motor performance. While age-related deterioration of reactive inhibition (stopping an action in response to an external signal) is well-es...
Associations of epigenetic age acceleration with motor impairment: Evidence from the Parkinson's Progression Markers Initiative cohort [0.03%]
表观遗传年龄加速与运动障碍的关联：来自帕金森病进展标志物倡议队列的证据
Tao Jiang,Julia Hui,Bowen Feng et al.
Tao Jiang et al.
Motor decline is a hallmark of Parkinson's disease (PD) and biological aging, yet the specific relationship between systemic biological aging and neuromotor function remains under-characterized. This study leveraged longitudinal phenotypic ...
Retraction notice to "Cognitive effects of cell-derived and synthetically-derived Aβ oligomers" [Neurobiol. Aging 32 (2009) 1784-1794] [0.03%]
有关《重性细胞来源及合成来源的Aβ寡聚体的认知效应》的撤稿通知[神经科学杂志32期(2009年第12期)1784-1794][神经老化]
Miranda N Reed,Jacki J Hofmeister,Lisa Jungbauer et al.
Miranda N Reed et al.
Ferritin-positive microglial clusters associate with microvessels and markers of vascular injury in MCI and Alzheimer's disease [0.03%]
额颞区铁蛋白阳性小胶质细胞簇与轻度认知障碍和阿尔茨海默病中小血管损伤的关联性研究
Lucy D Kerslake,Claire Noonan,Danielle S Davies et al.
Lucy D Kerslake et al.
Progressive cognitive decline in Alzheimer's disease is coupled with altered microglial function, and cerebrovascular pathologies. We investigated whether reactive microglia cell clusters and microvascular breakdown spatially overlap in hum...