Midlife insulin resistance and brain beta-amyloid accumulation as predictors of change in late-life cognitive function - A 20-year follow-up study [0.03%]
中年胰岛素抵抗和大脑β淀粉样蛋白积累对晚年认知功能变化的预测作用——一项20年的随访研究
Elina Pietilä,Mira Karrasch,Semi Helin et al.
Elina Pietilä et al.
The number of people with dementia will increase as populations age. Insulin resistance (IR) is associated with cognitive decline and dementia. We studied in this longitudinal, population-based cohort study, if change in late-life cognitive...
Oral body temperature and cerebrospinal fluid pTau181 in older adults at increased risk of Alzheimer's disease [0.03%]
口腔体温与增加阿尔茨海默病风险的老年人脑脊液pTau181的关系
Paul Pillet,Jennifer Tremblay-Mercier,Cynthia Picard et al.
Paul Pillet et al.
Preclinical studies consistently associate body temperature with tau phosphorylation in the brain. This study examined the relationship between body temperature taken at lumbar puncture (LP) and CSF pTau181 levels in 142 cognitively healthy...
Age-related differences in how tDCS priming modulates cortical inhibition during fatigue recovery [0.03%]
经颅直流电刺激对疲劳恢复期间皮质抑制作用的年龄差异研究
Eva K Moore,Lavender A Otieno,John G Semmler et al.
Eva K Moore et al.
Metaplasticity is homeostatic regulation of brain excitability through which neurons change their threshold for response based on synaptic history. Transcranial direct current stimulation (tDCS) induced metaplastic shifts in cortical excita...
Biopsychosocial and demographic predictors of functional brain network specialization and segregation across the adult lifespan [0.03%]
成人生命周期中功能脑网络专业化和分离的生物心理社会及人口统计学预测因素
A Shankar,M Phansikar,N McPherson et al.
A Shankar et al.
The properties of functional brain networks are an important determinant of cognitive function in aging and dementia. Despite this, few studies have comprehensively examined demographic and biopsychosocial predictors of functional brain net...
Post-traumatic stress disorder moderates the association between BrainAge acceleration and GrimAge acceleration [0.03%]
PTSD介导了脑年龄加速与grimAge衰老表型之间的关系
Jenna Beakas,Alexandra K Dwulit,Ahmed Hussain et al.
Jenna Beakas et al.
Individuals with post-traumatic stress disorder (PTSD) are at higher risk for age-related physical comorbidities, such as cardiovascular disorders, and exhibit accelerated epigenetic and brain aging. The present study examined PTSD as a mod...
Diffusion abnormalities associated with brain arteriolosclerosis: An in-vivo MRI and pathology study in community-based older adults [0.03%]
社区老年人基于人群的脑小动脉疾病的弥散异常：一种在体MRI和病理学研究
Ana Tomash,Mahir Tazwar,Md Tahmid Yasar et al.
Ana Tomash et al.
Brain arteriolosclerosis, a primary pathology of cerebral small vessel disease, is common in older adults and is associated with lower cognitive and motor function and higher odds of dementia. The purpose of this study was to test the hypot...
Early-life social enrichment induces divergent cognitive-emotional aging along with dorsal hippocampal VGluT1 and glial alterations [0.03%]
生命早期的社会丰富经历诱导海马背侧谷氨酸能神经元和胶质细胞的改变以及认知情绪老化表型的分化
Xiao-Xiao Ma,Jia-Ya Zheng,Xing-Duo Yao et al.
Xiao-Xiao Ma et al.
Early-life experiences can exert lasting impacts on brain function. While previous research has largely focused on early-life adversity, the long-term consequences of early-life enrichment on the aging brain remain poorly understood. In thi...
Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum and brain in younger and older mice [0.03%]
短期大麻烟暴露对年轻和年老小鼠血液和大脑炎症标志物的影响研究
Emely A Gazarov,Bailey McCracken,Zachary A Krumm et al.
Emely A Gazarov et al.
Aging is associated with chronic low-grade inflammation, which is thought to contribute to both cognitive decline and various neurodegenerative diseases. Cannabinoids are reported to reduce levels of inflammatory markers; however, these eff...
Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer's disease: Evidence from resting-state functional connectivity [0.03%]
多语言主义和认知储备在有老年痴呆风险的老年人中的作用：来自静息态功能连接的证据
Kristina Coulter,Tanya Dash,Tristin Best et al.
Kristina Coulter et al.
Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging...
Regional alterations of parvalbumin interneurons in human App knock-in mouse model of Alzheimer's disease pathology [0.03%]
人类APP敲入小鼠模型阿尔茨海默病病理改变区域的_parvalbumin_中间神经元的变化
Mercedes M Gonzalez,Benjamin Magondu,Matthew J M Rowan et al.
Mercedes M Gonzalez et al.
Early-stage Alzheimer's disease pathology correlates with disrupted neuronal excitability, which can drive network and cognitive dysfunction even prior to neurodegeneration. However, the emergence and extent of these changes may vary by bra...