Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden [0.03%]
基于解释性人工智能的AQP4多态性相关于脑淀粉样蛋白负担的风险评分分析
Simone Beer,David Elmenhorst,Gerard N Bischof et al.
Simone Beer et al.
Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome i...
Associations between brain structure and dual decline in gait and cognition [0.03%]
步态和认知双重下降与脑结构的关系
Sadhani Karunarathna,Monique Breslin,Jane Alty et al.
Sadhani Karunarathna et al.
Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations...
Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults [0.03%]
基于认知正常的老年人基线期主观认知抱怨预测脑萎缩及认知衰老轨迹
Michelle You,Cutter A Lindbergh,Renaud La Joie et al.
Michelle You et al.
Subjective cognitive concerns (SCC) are common even in cognitively normal older adults who lack objectively-detectable deficits on standard neuropsychological evaluation. The clinical relevance of these concerns, particularly considering th...
Older adults do not show enhanced benefits from multisensory information on speeded perceptual discrimination tasks [0.03%]
多重感觉信息在老年人速知觉辨别任务中未体现出增强效果
Christopher Atkin,Jemaine E Stacey,Harriet A Allen et al.
Christopher Atkin et al.
Some research has shown that older adults benefit more from multisensory information than do young adults. However, more recent evidence has shown that the multisensory age benefit varies considerably across tasks. In the current study, old...
Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks [0.03%]
与反应时间任务期间alpha和beta振荡的形态变化相关的年龄差异
George M Opie,James M Hughes,Rohan Puri
George M Opie
While the shape of cortical oscillations is increasingly recognised to be physiologically and functionally informative, its relevance to the aging motor system has not been established. We therefore examined the shape of alpha and beta band...
The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences [0.03%]
健康人在血糖控制、心率变异性以及自主神经脑功能之间的关联：不同年龄及性别间的差异
Jeffrey X Yu,Ahmad Hussein,Linda Mah et al.
Jeffrey X Yu et al.
Introduction: The purpose of this study was to clarify the relationships between glycemia and function of the autonomic nervous system (ANS), assessed via resting-state functional connectivity (FC) and heart-rate variabil...
Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with 11C-PiB beta-amyloid PET and 7T magnetic resonance spectroscopy [0.03%]
轻度认知障碍和晚年抑郁的神经病理学和神经代谢物的多模态调查：11C-PiB β淀粉样蛋白PET和7T磁共振波谱研究
Christopher W Davies-Jenkins,Clifford I Workman,Kathleen E Hupfeld et al.
Christopher W Davies-Jenkins et al.
Positron emission tomography (PET) and magnetic resonance spectroscopy (1H-MRS) are complementary techniques that can be applied to study how proteinopathy and neurometabolism relate to cognitive deficits in preclinical stages of Alzheimer'...
Free water-corrected fractional anisotropy of the fornix and parahippocampal cingulum predicts longitudinal memory change in cognitively healthy older adults [0.03%]
在认知健康的老年人中，海马柱和旁海马扣带回自由水校正分数各向异性预测纵向记忆变化
Mingzhu Hou,Maurizio Bergamino,Marianne de Chastelaine et al.
Mingzhu Hou et al.
Prior studies have reported inconsistent results regarding the relationships between the integrity of the fornix and parahippocampal cingulum and both memory performance and longitudinal change in performance. In the present study, we exami...
Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study [0.03%]
小鼠非线性的年龄相关学习差异研究——五臂赌博机任务研究
Hiroyuki Ohta,Takashi Nozawa,Takashi Nakano et al.
Hiroyuki Ohta et al.
This study explores the impact of aging on reinforcement learning in mice, focusing on changes in learning rates and behavioral strategies. A 5-armed bandit task (5-ABT) and a computational Q-learning model were used to evaluate the positiv...
Associations of cerebrovascular disease and Alzheimer's disease pathology with cognitive decline: Analysis of the National Alzheimer's Coordinating Center Uniform Data Set [0.03%]
脑血管病和阿尔茨海默病病理与认知下降的关系：来自全美阿尔兹海默病协调中心统一数据集的分析研究
Ankita Chatterjee,Shannon Lee,Valentina Diaz et al.
Ankita Chatterjee et al.
Cerebrovascular disease (CVD) and Alzheimer's disease (AD) often co-occur and may impact specific cognitive domains. This study's goal was to determine effects of CVD and AD burden on cross-sectional and longitudinal executive function (EF)...