Cardiovascular risk of dementia is associated with brain-behaviour changes in cognitively healthy, middle-aged individuals [0.03%]
血管性痴呆风险与认知健康中年人的大脑行为改变有关
Feng Deng,Maria-Eleni Dounavi,Emanuele R G Plini et al.
Feng Deng et al.
Alzheimer's Disease (AD) neuropathology start decades before clinical manifestations, but whether risk factors are associated with early cognitive and brain changes in midlife remains poorly understood. We examined whether AD risk factors w...
Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study [0.03%]
来自LEISURE研究的横断面发现：健康老龄化状态下注意力维持与静息态脑电的关系
Alicia J Campbell,Toomas Erik Anijärv,Thomas Pace et al.
Alicia J Campbell et al.
While structural and biochemical brain changes are well-documented in ageing, functional neuronal network differences, as indicated by electrophysiological markers, are less clear. Moreover, age-related changes in sustained attention and th...
Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood [0.03%]
与成人期脑铁蓄积相关的 lifestyle、生物学和遗传因素
Jonatan Gustavsson,Zuzana Ištvánfyová,Goran Papenberg et al.
Jonatan Gustavsson et al.
Iron is necessary for many neurobiological mechanisms, but its overaccumulation can be harmful. Factors triggering age-related brain iron accumulation remain largely unknown and longitudinal data are insufficient. We examined associations b...
Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice [0.03%]
小鼠慢性系统性炎症后年龄依赖性的性别差异及突杆蛋白1通路（LIMK1/SSH1）与AD生物标志物的关系
Amsha S Alsegiani,Zahoor A Shah
Amsha S Alsegiani
Chronic systemic inflammation (CSI) results in neuroinflammation and neurodegeneration. Cofilin1 is a stress protein that activates microglia and induces neuroinflammation, but its role in CSI at different aging stages remains unidentified....
Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease [0.03%]
母体胆碱补充可缓解Ts65Dn(唐氏综合症和阿尔茨海默病的小鼠模型)小鼠底纹状核胆碱能神经元早期囊泡病理损伤
Megan K Gautier,Christy M Kelley,Sang Han Lee et al.
Megan K Gautier et al.
Individuals with DS develop Alzheimer's disease (AD) neuropathology, including endosomal-lysosomal system abnormalities and degeneration of basal forebrain cholinergic neurons (BFCNs). We investigated whether maternal choline supplementatio...
The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study [0.03%]
年龄、性别和谷胱甘肽之间的联系：一项基于磁共振波谱的横断面研究
Lars Michels,Ruth O&#x;Gorman-Tuura,Dario Bachmann et al.
Lars Michels et al.
Glutathione (GSH) is a brain marker for oxidative stress and has previously been associated with cerebral amyloid deposition and memory decline. However, to date, no study has examined the links among GSH, sex, age, amyloid, and Apolipoprot...
The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults [0.03%]
血浆淀粉样蛋白β42/38比值在认知正常老年人早期记忆障碍中的生物标志物价值
Alison R Bamford,Jenna N Adams,Soyun Kim et al.
Alison R Bamford et al.
The amyloid beta (Aβ) 42/40 ratio has been widely studied as a biomarker in Alzheimer's disease (AD); however, other Aβ peptides could also represent relevant biomarkers. We measured levels of Aβ38/40/42 in plasma samples from cognitivel...
Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer's disease with MRI and CSF biomarkers [0.03%]
超越组分类：基于MRI和CSF生物标志物的额颞叶痴呆和阿尔茨海默病的概率鉴别诊断
Agnès Pérez-Millan,Bertrand Thirion,Neus Falgàs et al.
Agnès Pérez-Millan et al.
Neuroimaging and fluid biomarkers are used to differentiate frontotemporal dementia (FTD) from Alzheimer's disease (AD). We implemented a machine learning algorithm that provides individual probabilistic scores based on magnetic resonance i...
Contrasting association pattern of plasma low-density lipoprotein with white matter integrity in APOE4 carriers versus non-carriers [0.03%]
载脂蛋白E4基因携带者和非携带者血浆低密度脂蛋白与白质完整性的关联模式对比研究
Zhenyao Ye,Yezhi Pan,Rozalina G McCoy et al.
Zhenyao Ye et al.
Apolipoprotein E ε4 (APOE4) is a strong genetic risk factor of Alzheimer's disease and metabolic dysfunction. However, whether APOE4 and markers of metabolic dysfunction synergistically impact the deterioration of white matter (WM) integri...
Plasma p-tau181 and amyloid markers in Alzheimer's disease: A comparison between Lumipulse and SIMOA [0.03%]
基于Lumipulse和SIMOA检测方法的轻链p- tau181和淀粉样蛋白标志物在阿尔茨海默病中的比较研究
Virginia Quaresima,Andrea Pilotto,Chiara Trasciatti et al.
Virginia Quaresima et al.
Aim of the project was to evaluate the technical and clinical validity of plasma Lumipulse p-tau, Aβ42 and Aβ40 species and their correlation with CSF core Alzheimer's Disease (AD) markers; a method comparison with SIMOA was also performe...
Comparative Study
Neurobiology of aging. 2024 Nov:143:30-40. DOI:10.1016/j.neurobiolaging.2024.08.007 2024