Cross-sectional and longitudinal relationships among blood-brain barrier disruption, Alzheimer's disease biomarkers, and cognition in cognitively normal older adults [0.03%]
正常老化人群中血脑屏障破坏、阿尔茨海默病生物标志物和认知之间的横断面及纵向关系
Marisa Denkinger,Suzanne Baker,Theresa M Harrison et al.
Marisa Denkinger et al.
Blood-brain barrier disruption (BBBd) occurs in aging, particularly in regions vulnerable to Alzheimer's disease (AD) pathology. However, its relationship to pathological protein accumulation, neurodegeneration, and cognitive impairment in ...
Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease [0.03%]
钙调神经磷酸酶/NFAT抑制剂在阿尔茨海默病老化犬模型的临床前预防研究中维持认知功能
Lorena Sordo,Margo F Ubele,Kathy A Boaz et al.
Lorena Sordo et al.
Brain signaling of calcineurin (CN) and nuclear factor of activated T-cells (NFAT) transcription factor increases in Alzheimer disease (AD) and is associated with synaptic loss, neurodegeneration, neuroinflammation, amyloid-β (Aβ) product...
Hypertension may associate with cerebral small vessel disease and infarcts through the pathway of intracranial atherosclerosis [0.03%]
高血压通过颅内动脉粥样硬化途径与脑小血管病及梗死相关
Marcelo Kenzo Naya Takahashi,Regina Silva Paradela,Lea Tenenholz Grinberg et al.
Marcelo Kenzo Naya Takahashi et al.
Hypertension, a major modifiable risk factor for cardiovascular diseases, is linked to late-life neurocognitive disorders such as vascular dementia and Alzheimer's disease (AD). This study explores the associations between hypertension, int...
A neural implementation of cognitive reserve: Insights from a longitudinal fMRI study of set-switching in aging [0.03%]
基于纵向功能磁共振成像字母转换任务研究的认知储备神经机制
Fatemeh Hasanzadeh,Christian Habeck,Yunglin Gazes et al.
Fatemeh Hasanzadeh et al.
Aging is often accompanied by changes in brain structure and executive functions, particularly in tasks involving cognitive flexibility, such as task-switching. However, substantial individual differences in the degree of cognitive impairme...
Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults [0.03%]
认知正常的老年人中淀粉样蛋白和tau与执行功能和记忆纵向关系的研究
Xi Chen,Alexis Juarez,Suzanne Mason et al.
Xi Chen et al.
The early accumulation of AD pathology such as Aβ and tau in cognitively normal older people is predictive of cognitive decline, but it has been difficult to dissociate the cognitive effects of these two proteins. Early Aβ and tau target ...
M1 muscarinic receptor activation reverses age-related memory updating impairment in mice [0.03%]
激活M1胆碱能受体可逆转小鼠年龄相关的记忆更新障碍
Kristen H Jardine,Emily P Minard,Cassidy E Wideman et al.
Kristen H Jardine et al.
Previously consolidated memories can become temporarily labile upon reactivation. Reactivation-based memory updating is chiefly studied in young subjects, so we aimed to assess this process across the lifespan. To do this, we developed a be...
Sabrina Reinehr,M Rahim Pamuk,Rudolf Fuchshofer et al.
Sabrina Reinehr et al.
Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. βB1-Connective Tissue Growth Factor (βB1-CTGF) high-pressure glaucoma mice were used in this study to assess whe...
Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice [0.03%]
酒精消耗对小鼠衰老大脑中前额皮质神经元固有兴奋性和自发性神经递质信号传导产生持久影响
Grace C Smith,Keith R Griffith,Avery R Sicher et al.
Grace C Smith et al.
Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of alcohol use on excitation and inhibition on the aging brain is unclear. We examine...
Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: The Rotterdam Study [0.03%]
老年人大脑白质微观结构纵向变化与听力下降的关系：鹿特丹研究项目数据
Jordi H C Boons,Elisabeth J Vinke,Gertjan Dingemanse et al.
Jordi H C Boons et al.
Hearing loss is considered a potentially modifiable risk factor for dementia. The sensory deprivation theory postulates that hearing loss adversely affects cognition in older adults through structural brain changes, but longitudinal studies...
Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease [0.03%]
淀粉样蛋白病理改变及认知功能障碍转基因小鼠模型研究
Wenyan Lu,Francis Shue,Aishe Kurti et al.
Wenyan Lu et al.
The hAβ-KI and APPSAA-KI are two amyloid models that harbor mutations in the endogenous mouse App gene. Both hAβ-KI and APPSAA-KI mice contain a humanized Aβ sequence, and APPSAA-KI mice carry three additional familial AD mutations. We h...