Modeling functional loss in Alzheimer's Disease through cognitive reserve and cognitive state: A panel data longitudinal study [0.03%]
通过认知储备和认知状态建模阿尔茨海默病的功能丧失：一项板块数据纵向研究
Laura Veronelli,Giorgia Tosi,Daniele Romano;Alzheimer’s Disease Neuroimaging Initiative
Laura Veronelli
Cognitive Reserve (CR) refers to the brain's ability, supported by active and modifiable forms of lifestyle compensation, to cope with neural changes due to age or disease, delaying the onset of cognitive deficits. In CR studies, neuropsych...
Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer's disease pathology [0.03%]
β淀粉样蛋白沉积小鼠阿尔茨海默病病理模型中，通过α5-GABAA受体正向别构调节产生改善认知和神经营养的益处
Ashley M Bernardo,Michael Marcotte,Kayla Wong et al.
Ashley M Bernardo et al.
Reduced somatostatin (SST) and SST-expressing GABAergic neurons are well-replicated findings in Alzheimer's disease (AD) and are associated with cognitive deficits. SST cells inhibit pyramidal cell dendrites through α5-GABA-A receptors (α...
Mismatch negativity predicts age-related declines in memory precision [0.03%]
mismatch negativity预测记忆精确度的年龄相关衰退现象
Ricky Chow,Stevenson Baker,Shimin Mo et al.
Ricky Chow et al.
Does precision in auditory perception predict precision in subsequent memory (i.e., mnemonic discrimination) in aging? This study examined if the mismatch negativity (MMN), an electrophysiological marker of change detection and encoding, re...
Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults [0.03%]
独立的睡眠和身体活动与认知的关系通过海马微结构在中老年人群中的中介作用
Daniel D Callow,Adam P Spira,Vadim Zipunnikov et al.
Daniel D Callow et al.
Sleep and physical activity levels are both associated with cognitive performance among older adults; however, the brain mechanisms underlying these beneficial relationships remain poorly understood. This study investigated cross-sectional ...
Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults [0.03%]
蓝斑磁共振对比剂、脑血流与老年人大肠埃希菌生物标志物
Shubir Dutt,Shelby L Bachman,Martin J Dahl et al.
Shubir Dutt et al.
The locus coeruleus (LC) is among the first brain structures impacted by Alzheimer's disease (AD), and noradrenergic denervation may contribute to early neurovascular dysfunction in AD. Mechanistic links between the LC and cerebral perfusio...
Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults [0.03%]
中老年人运动皮质、初级体感皮层和小脑功能连接与平衡表现之间的关系
Ashwini Sansare,Thamires N C Magalhaes,Jessica A Bernard
Ashwini Sansare
Connectivity of somatosensory cortex (S1) and cerebellum with the motor cortex (M1) is critical for balance control. While both S1-M1 and cerebellar-M1 connections are affected with aging, the implications of altered connectivity for balanc...
Hippocampal atrophy over two years in relation to tau, amyloid-β and memory in older adults [0.03%]
tau、淀粉样蛋白-β和记忆与老年人海马区两年内的萎缩关系的研究
Etienne Aumont,Marc-André Bedard,Aurélie Bussy et al.
Etienne Aumont et al.
In this longitudinal brain imaging study, we aimed to characterize hippocampal tau accumulation and subfield atrophy relative to cortical amyloid-β and memory performance. We measured tau-PET in regions associated with Braak stages I to VI...
Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition [0.03%]
多巴胺能遗传倾向在中皮质厚度和执行功能生命跨度纵向变化中的作用
Giuseppe G Miranda,Chen Gonen,Jessica N Kraft et al.
Giuseppe G Miranda et al.
Dopamine (DA) signaling is critical for optimal cognitive aging, especially in prefrontal-parietal and fronto-striatal networks. Single nucleotide polymorphisms associated with dopamine regulation, COMTVal158Met and DRD2C957T, stand to exer...
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals [0.03%]
来自15个队列的脑白质高信号容积正常值：包括14876名个体的年龄和性别特异性数据
Floor A S de Kort,Elisabeth J Vinke,Ewoud J van der Lelij et al.
Floor A S de Kort et al.
White matter hyperintensities (WMH) increase with age, with marked interindividual variation. There is a need for normative data by age and sex, to improve individualized WMH burden assessment. In this study, we pooled cross-sectional data ...
Effects of age and dietary methionine restriction on cognitive and behavioural phenotypes in the rTg4510 mouse model of frontotemporal dementia [0.03%]
饮食甲硫氨酸限制对rTg4510阿尔茨海默病小鼠模型认知和行为表型的影响
Marina Souza Matos,Annesha Sil,Gernot Riedel et al.
Marina Souza Matos et al.
Metabolic disorders such as diabetes and obesity are linked to neurodegenerative diseases, with evidence of lower brain glucose metabolism and insulin resistance in dementia patients. Dietary methionine restriction (MR) is a nutritional int...