Blood-brain barrier water permeability across the adult lifespan: A multi-echo ASL study [0.03%]
成人生命周期中的血脑屏障水平衡渗透性：多回波ASL研究
Beatriz E Padrela,Maksim Slivka,Markus H Sneve et al.
Beatriz E Padrela et al.
An emerging biomarker of blood-brain barrier (BBB) permeability is the time of exchange (Tex) of water from the blood to tissue, as measured by multi-echo arterial spin labeling (ASL) MRI. This new non-invasive sequence, already tested in m...
Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model [0.03%]
Tau与突触线粒体的相互作用在P301Stau病小鼠模型中与能量代谢障碍和兴奋性突触丢失同时发生
L Daniel Estrella,Andrew J Trease,Lexi Sheldon et al.
L Daniel Estrella et al.
Neurodegenerative Tauopathies are a part of several neurological disorders and aging-related diseases including, but not limited to, Alzheimer's Disease, Frontotemporal Dementia with Parkinsonism, and Chronic Traumatic Encephalopathy. The m...
Recollection-related fMRI effects in entorhinal cortex predict longitudinal memory change in healthy older adults [0.03%]
内侧颞叶衰老和阿尔茨海默病早期的回忆相关效应预测记忆衰退
Ambereen Kidwai,Mingzhu Hou,Marianne de Chastelaine et al.
Ambereen Kidwai et al.
The present study examines whether structural and functional variability in medial temporal lobe (MTL) neocortical regions correlate with individual differences in episodic memory and longitudinal memory change in cognitively healthy older ...
Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage [0.03%]
血管内皮生长因子受体-1（FLT1）与阿尔茨海默病中的淀粉样蛋白-β的相互作用：淀粉样蛋白诱导的血管损伤的潜在生物标志物
Rebecca L Winfree,Emma Nolan,Kaj Blennow et al.
Rebecca L Winfree et al.
We have identified FLT1 as a protein that changes during Alzheimer's disease (AD) whereby higher brain protein levels are associated with more amyloid, more tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis a...
Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers [0.03%]
与认知和阿尔茨海默病生物标志物相关的脑老化亚型
Elettra Capogna,Øystein Sørensen,Leiv Otto Watne et al.
Elettra Capogna et al.
Structural brain changes underlie cognitive changes and interindividual variability in cognition in older age. By using structural MRI data-driven clustering, we aimed to identify subgroups of cognitively unimpaired older adults based on br...
Effector-dependent decline in strength and subcortical motor excitability with aging [0.03%]
效应器依赖的肌肉力量和皮下运动兴奋性随年龄的增长而减退
Ronan A Mooney,Pablo A Celnik
Ronan A Mooney
A decline in upper limb strength is common with normal aging. However, whether age-related strength decline is paralleled by reduced excitability of descending motor pathways is unclear. The reticulospinal tract is a key subcortical pathway...
New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice [0.03%]
一种具有治疗阿尔茨海默病潜力的新型低剂量姜黄素衍生物：小鼠体内的离体和在体研究结果
Beatriz Rodrigues,Eduarda Ventura,Patrícia Moreira et al.
Beatriz Rodrigues et al.
Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability to inhibit amyloid-β (Aβ) peptide aggregates and to destabilise pre-formed ones. Derivative 27 was synthesized to improve low-dose efficac...
Corrigendum to "Modulation of lipopolysaccharide-induced memory insult, g-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase" [Neurobiol. Aging 35 (2014) 1024-1031 ] [0.03%]
关于“5-脂氧合酶对三转基因小鼠脂多糖诱导的损伤、γ分泌酶和神经炎症的调节作用”的勘误注释
Yash B Joshi,Phillip F Giannopoulos,Jin Chu et al.
Yash B Joshi et al.
A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice [0.03%]
一种新型的14肽T14与小鼠年龄相关的行为有关
Sibah Hasan,Adam Mohammed Khan,Sara Garcia-Ratés et al.
Sibah Hasan et al.
Age-related cognitive decline presents a healthcare challenge. While age-related mechanisms are mainly studied in humans, animal models provide key insights. Despite evidence of sex-specific differences in aging and cognition, the impact of...
Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging [0.03%]
大脑衰老的个体差异：用于研究衰老过程中功能网络的个体化方法的实用性综述及展望
Diana C Perez,Joanna J Hernandez,Gretchen Wulfekuhle et al.
Diana C Perez et al.
Healthy aging is associated with cognitive decline across multiple domains, including executive function, memory, and attention. These cognitive changes can often influence an individual's ability to function and quality of life. However, t...