Systemic infections alter cortical transcriptional signatures in Alzheimer's disease [0.03%]
系统性感染会改变阿尔茨海默病皮质转录特征
Giulia Pegoraro,Lachlan F MacBean,Adam R Smith et al.
Giulia Pegoraro et al.
Alzheimer's disease (AD) is characterized by neuroinflammation, yet the impact of concurrent systemic infections on the AD brain remains poorly understood. We investigated the molecular mechanisms underlying the central nervous system respo...
Exogenous mitochondrial transplantation attenuates oxidative stress-driven retinal degeneration in a sodium iodate - induced mouse model [0.03%]
外源线粒体移植通过减轻氧化应激诱导的小鼠视网膜退变的作用
Seok Jae Lee,Sung-Eun Noh,Jeong Hun Kim
Seok Jae Lee
Age-related macular degeneration (AMD) is a degenerative retinal disease initiated by dysfunction of the retinal pigment epithelium (RPE), in which age-related mitochondrial impairment, oxidative stress, chronic inflammation, and complement...
Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults [0.03%]
老年人压力应对方式的脑结构标志：心理韧性与孤独感的作用
Jessica K Hur,Jiya N Shah,Nhu Huynh et al.
Jessica K Hur et al.
Loneliness and social isolation increase the risk of physical and mental disorders in older adults, while resilience may mitigate this risk. The evidence that medial temporal lobe (MTL) structures are associated with loneliness, social isol...
Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease [0.03%]
主观认知下降、轻度认知障碍和阿尔茨海默病中海马-皮层结构网络的改变：基于源的形态测量分析结果
Laura Serra,Matteo Mancini,Sabrina Bonarota et al.
Laura Serra et al.
Neural plasticity and memory mechanisms progressively change during pathological aging. This study aimed to identify patterns of structural covariance across Alzheimer's disease (AD) stages and their relationship with episodic memory perfor...
Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span [0.03%]
顶叶皮质和蓝斑结构与终生复杂精神活动参与度在晚年有关
Jennifer L Crawford,Hsiang-Yu Chen,Alex A Adornato et al.
Jennifer L Crawford et al.
There is great interest in characterizing the activities or lifestyle factors that are important for successful aging; nevertheless, rigorous investigations using multimodal neuroimaging measures in conjunction with validated measures of ac...
Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated [0.03%]
运动学习、感觉运动神经化学和皮层反应性随年龄变化但彼此独立
Marten Nuyts,Sima Chalavi,Geraldine Rodriguez-Nieto et al.
Marten Nuyts et al.
Age-related declines in motor learning are commonly attributed to changes in sensorimotor neurophysiology. However, direct links between neurochemistry, electrophysiology, and behavior are scarce. Here, we investigated whether age-related d...
How cognition and hearing-related measures covary with hippocampal subfield features from structural MRI in younger and older adults [0.03%]
认知与听力相关指标如何通过结构磁共振影像的大脑海马亚区特征在年轻人和老年人中变化规律的研究
Imola X MacPhee,Josh Goheen,Melanie J Sekeres et al.
Imola X MacPhee et al.
Hippocampal atrophy across the lifespan is associated with cognitive decline, as is difficulty understanding speech-in-noise. The hippocampus contains subfields with distinct functions, but their involvement in hearing-related differences i...
Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals [0.03%]
认知下降意识减退与无认知障碍个体多模式阿尔茨海默病生物标志物相关
David López-Martos,Marc Suárez-Calvet,Gemma Salvadó et al.
David López-Martos et al.
Alzheimer's disease (AD) diagnostic guidelines emphasize subjective cognitive decline (SCD) preceding mild cognitive impairment (MCI), implicitly assuming awareness of cognitive decline (ACD) is preserved in preclinical AD. This study aimed...
Review of current research practices in social and structural determinants of health data collection in Canadian longitudinal cohorts of aging and dementia [0.03%]
加拿大纵向队列中关于社会和结构健康决定因素数据收集的当前研究实践的回顾（痴呆与老龄化）
Stefanie A Tremblay,Juhi Tulsi,Dimitri Yang et al.
Stefanie A Tremblay et al.
Background: Social and structural determinants of health (SSDH) are key drivers of disparities in cognitive aging and dementia risk, yet their collection in aging and dementia research remains inconsistent. We examined SS...
Global brain maintenance predicts well-preserved cognitive function: A pooled analysis of three longitudinal population-based Swedish cohorts [0.03%]
全球大脑维护预测认知功能良好：瑞典三项纵向人群队列研究的综合分析
Saana M Korkki,Justinas Narbutas,Alireza Salami et al.
Saana M Korkki et al.
Substantial heterogeneity in cognitive ageing is well documented. Such heterogeneity has been attributed to individual differences in brain maintenance - i.e., the relative preservation of neural resources in ageing. However, large-scale lo...