Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease [0.03%]
阿尔茨海默病中记忆无意识的领域特殊性和神经相关性探究
Lucile Meunier-Duperray,Céline Souchay,Lucie Angel et al.
Lucile Meunier-Duperray et al.
Patients with Alzheimer's disease (AD) are less accurate than controls to predict their episodic performance, but they are as accurate as controls to predict their semantic performance. However, the dissociation between episodic and semanti...
Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [18F]-fluoroethoxybenzovesamicol positron emission tomography imaging [0.03%]
与普通对照组相比，唐氏综合症成人组乙酰胆碱末梢密度的差异：[18F]-fluoroethoxybenzovesamicol正电子发射断层扫描影像研究
Jason K Russell,Alexander C Conley,Brian D Boyd et al.
Jason K Russell et al.
Adults with Down syndrome are genetically predisposed to developing Alzheimer's disease after the age of 40. The cholinergic system, which is critical for cognitive functioning, is known to decline in Alzheimer's disease and although first ...
Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques [0.03%]
认知障碍恒河猴黑素浓集层神经元数量不受大脑体积损失影响
Kelsey E McDermott,Carol A Barnes
Kelsey E McDermott
The locus coeruleus (LC) is a brainstem nucleus that provides the primary source of noradrenaline (NA) in the nervous system and optimizes behavioral performance in mammals. In humans, the LC shows Alzheimer's disease (AD)-like pathology at...
Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging [0.03%]
健康老龄化中深层皮层铁含量与功能连接和流体智力的关系
Jenna L Merenstein,Jiayi Zhao,David J Madden
Jenna L Merenstein
Age-related differences in fluid cognition have been associated with both the merging of functional brain networks, defined from resting-state functional magnetic resonance imaging (rsfMRI), and with elevated cortical iron, assessed by quan...
Inter-network functional connectivity increases by beta-amyloid and may facilitate the early stage of tau accumulation [0.03%]
淀粉样蛋白增加时脑网络间功能连接性增强并可能促进tau过度磷酸化早期阶段的发展
Seyed Hani Hojjati,Tracy A Butler,Mony de Leon et al.
Seyed Hani Hojjati et al.
Alzheimer's disease (AD) is pathologically marked by tau tangles and beta-amyloid (Aβ) plaques. It has been hypothesized that Aβ facilitates spread of tau outside of the medial temporal lobe (MTL), but exact mechanism of this facilitation...
Network segregation during episodic memory shows age-invariant relations with memory performance from 7 to 82 years [0.03%]
从7岁到82岁期间，间歇性记忆的网络分割与记忆表现的关系不变
Håkon Grydeland,Markus H Sneve,James M Roe et al.
Håkon Grydeland et al.
Lower episodic memory capability, as seen in development and aging compared with younger adulthood, may partly depend on lower brain network segregation. Here, our objective was twofold: (1) test this hypothesis using within- and between-ne...
The moderating effect of diet on the relationship between depressive symptoms and Alzheimer's disease-related blood-based biomarkers [0.03%]
饮食对抑郁症症状与阿尔茨海默病相关血液生物标志物关系的调节作用
Hilal Salim Said Al Shamsi,Samantha L Gardener,Stephanie R Rainey-Smith et al.
Hilal Salim Said Al Shamsi et al.
Associations between mental health, diet, and risk of Alzheimer's disease highlight the need to investigate whether dietary patterns moderate the relationship between symptoms of depression and anxiety, and neurodegeneration-related blood-b...
Brain mechanical properties predict longitudinal cognitive change in aging and Alzheimer's disease [0.03%]
脑机械属性预测衰老和阿尔茨海默病的纵向认知变化
KowsalyaDevi Pavuluri,John Huston rd,Richard L Ehman et al.
KowsalyaDevi Pavuluri et al.
Age-related cognitive decline is a complex phenomenon that is influenced by various neurobiological processes at the molecular, cellular, and tissue levels. The extent of this decline varies between individuals and the underlying determinan...
Neural effects of memory training to reduce false memories in older adults: Univariate and multivariate analyses [0.03%]
减缓老年人错误记忆的神经效应：单变量和多变量分析
Indira C Turney,Ashley C Steinkrauss,Rebecca L Wagner et al.
Indira C Turney et al.
The growing population of older adults emphasizes the need to develop interventions that prevent or delay some of the cognitive decline that accompanies aging. In particular, as memory impairment is the foremost cognitive deficit affecting ...
David J Madden
David J Madden