Chronic pain and its association with cognitive decline and brain function abnormalities in older adults: Insights from EEG and neuropsychological assessment [0.03%]
慢性疼痛及其与老年人认知衰退和脑功能异常的关系：来自EEG和神经心理评估的见解
A M González-Roldán,M Delgado-Bitata,A Dorado et al.
A M González-Roldán et al.
Studies examining the interplay between chronic pain, cognitive function, and functional brain abnormalities in older adults are scarce. To address this gap, we administered a series of neuropsychological tests and recorded electroencephalo...
Stanislau Hrybouski,Sandhitsu R Das,Long Xie et al.
Stanislau Hrybouski et al.
Alzheimer's disease (AD) is characterized by a long preclinical stage during which molecular markers of amyloid beta and tau pathology rise, but there is minimal neurodegeneration or cognitive decline. Previous literature suggests that meas...
Age-related differences in resting glutamate levels and glutamate uptake in the hippocampus and frontal cortex of C57BL/6 mice [0.03%]
C57BL/6小鼠海马和前额皮层静息谷氨酸水平和谷氨酸摄取的年龄相关差异
Francois Pomerleau,Brittany A Sulkowski,Cocanut Suhail et al.
Francois Pomerleau et al.
In normal aging, little is known in human and animal models about functional changes to glutamate neuronal systems that may contribute to age-related cognitive differences. The present studies investigated glutamate neuronal signaling in th...
Long-term nucleus basalis cholinergic lesions alter the structure of cortical vasculature, astrocytic density and microglial activity in Wistar rats [0.03%]
基底核胆碱能长期损伤改变Wistar大鼠皮层血管结构，星形胶质细胞密度和小神经胶质活性
Chiara Orciani,Morgan K Foret,A Claudio Cuello et al.
Chiara Orciani et al.
Basal forebrain cholinergic neurons (BFCNs) are the sole source of cholinergic innervation to the cerebral cortex and hippocampus in humans and the primary source in rodents. This system undergoes early degeneration in Alzheimer's disease. ...
Age-related differences in locus coeruleus intensity across a demographically diverse sample [0.03%]
不同年龄群体在蓝斑强度上的差异性分析
Elizabeth Riley,Nicholas Cicero,Senegal Alfred Mabry et al.
Elizabeth Riley et al.
Understanding the trajectory of in vivo locus coeruleus (LC) signal intensity across the adult lifespan and among various demographic groups, particularly during middle age, may be crucial for early detection of neurodegenerative diseases, ...
Relation of Alzheimer's disease-related TDP-43 proteinopathy to metrics from diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) [0.03%]
与阿尔茨海默病相关的TDP-43蛋白病与来自扩散张量成像(DTI)和神经丝方向色散及密度成像(NODDI)的参数之间的关系
Anna Lavrova,Nha Trang Thu Pham,Robert I Reid et al.
Anna Lavrova et al.
Transactive response DNA-binding protein 43 kDa (TDP-43) deposition is linked to regional brain atrophy in Alzheimer's disease (AD), but diffusion changes associated with AD-related TDP-43 proteinopathy remain underexplored. This study eval...
Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer's disease [0.03%]
性别的APOE4特异性关联和心血管危险因素以及有阿尔茨海默病家族史的个体的白质改变的关系
Stefanie A Tremblay,R Nathan Spreng,Alfie Wearn et al.
Stefanie A Tremblay et al.
Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming to prevent progression will likely be most effective when initiated early. White matter (...
Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina [0.03%]
随着年龄和损伤增加的小鼠视网膜兴奋性和抑制性神经递质的变化
Katharina C Bell,Vicki Chrysostomou,Markus Karlsson et al.
Katharina C Bell et al.
Increasing age and elevated intraocular pressure (IOP) are the two major risk factors for glaucoma, the most common cause of irreversible blindness worldwide. Accumulating evidence is pointing to metabolic failure predisposing to neuronal l...
Age-related differences in task-related modulation of cerebellar brain inhibition [0.03%]
小脑脑抑制在任务相关调制中的年龄差异
Shanti Van Malderen,Melina Hehl,Marten Nuyts et al.
Shanti Van Malderen et al.
Age-related reductions in cerebellar integrity predict motor impairments in older adults (OA), but the contribution of cerebro-cerebellar interactions to these impairments remains unclear. Understanding these interactions could reveal under...
White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy [0.03%]
白质高信号在路易体痴呆和后皮层萎缩中的表现
Neha Singh-Reilly,Nha Trang Thu Pham,Jonathan Graff-Radford et al.
Neha Singh-Reilly et al.
Dementia with Lewy bodies (DLB) and posterior cortical atrophy (PCA) are neurodegenerative disorders that can overlap clinically and in patterns of regional hypometabolism and show elevated white matter hyperintensity (WMH) burden. Little i...