Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia [0.03%]
轻度路易体痴呆前期神经精神症状的相关脑网络改变
Laura M Wright,Paul C Donaghy,David J Burn et al.
Laura M Wright et al.
Neuropsychiatric symptoms (NPS) are prevalent, emerge early, and are associated with poorer outcomes in Lewy body dementia (LBD). Research suggests NPS may reflect LBD-related dysfunction in distributed neuronal networks. This study investi...
Persistent blood-brain barrier dysregulation in patients with obstructive sleep apnea following long-term continuous positive airway pressure treatment [0.03%]
持续气道正压治疗后阻塞性睡眠呼吸暂停患者血脑屏障失调的持久性
Mariana Fernandes,Fabio Placidi,Francesca Izzi et al.
Mariana Fernandes et al.
Introduction: Blood-brain barrier (BBB) dysfunction has been hypothesized to be a triggering factor in neurodegeneration. This study compared moderate-severe obstructive sleep apnea (OSA) patients with controls to evaluat...
Isabelle L Moore,Devyn E Smith,Nicole M Long
Isabelle L Moore
Healthy older adults typically show impaired episodic memory - memory for when and where an event occurred. This selective episodic memory deficit may arise from differential engagement in the retrieval state, a brain state in which attenti...
Higher soluble ADAM10 plasma levels are associated with decreased cognitive performance in older adults carrying APOEε4 [0.03%]
较高水平的可溶性ADAM10与APOEε4携带老年人的认知功能下降有关
Lucas Nogueira de Carvalho Pelegrini,Patricia Regina Manzine,Cecilia Patricia Popolin et al.
Lucas Nogueira de Carvalho Pelegrini et al.
The APOE gene, particularly its ε4 allele, is a significant genetic risk factor for Alzheimer's disease (AD) and influences amyloid-β (Aβ) pathology and cognitive decline. This study explores the relationship between APOEε4 genotype, pl...
Dynamics and role of covalently-closed circular RNAs in Alzheimer's disease: A review of experimental and bioinformatics studies [0.03%]
阿尔茨海默病中共价闭合环形RNA的动力学和作用：实验及生物信息学研究综述
Nikta Zafarjafarzadeh,Elham Feridouni,Sudabe Sobhani-Moghaddam et al.
Nikta Zafarjafarzadeh et al.
Alzheimer's disease (AD) is an age-associated disorder characterized by cognitive decline, with dementia representing the final stage of a complex clinical-biological process rather than simply a more severe form of cognitive decline. Circu...
Brain microRNAs differentially expressed in age-related cerebral pathologies [0.03%]
与年龄相关的脑病理异常表达的微小核糖核酸
Tianze Luo,Selina M Vattathil,Adriana Lori et al.
Tianze Luo et al.
Multiple brain pathologies accumulate with age, but their underlying biology remains unclear. We investigated the role of microRNAs (miRNAs) in ten age-related cerebral pathologies. Using miRNA sequencing profiles from the dorsolateral pref...
Lower aperiodic EEG activity is associated with reduced verbal fluency performance across adulthood [0.03%]
成人较低的非周期性EEG活动与语言流畅度表现降低有关
Daniel J McKeown,Emily Roberts,Anna J Finley et al.
Daniel J McKeown et al.
Age-related cognitive decline associations with human electroencephalography (EEG) have previously focused on periodic activity. However, EEG primarily consists of non-oscillatory aperiodic activity, characterised with an exponent and offse...
A more irregular shape of white matter hyperintensities is associated with cognitive decline over five years in community-dwelling older adults [0.03%]
形态的白质高信号与社区中老年人群五年内的认知衰退有关
Jasmin Annica Kuhn-Keller,Sigurdur Sigurdsson,Lenore J Launer et al.
Jasmin Annica Kuhn-Keller et al.
WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults. The current study aimed to investigate the association of WMH shape and decline in three cognitive domains over five years' time in ...
Gene age gap estimate (GAGE) for major depressive disorder: A penalized biological age model using gene expression [0.03%]
抑郁症的基因年龄差距估计(GAGE): 基于基因表达的惩罚化生物年龄模型
Yijie Jamie Li,Rayus Kuplicki,Bart N Ford et al.
Yijie Jamie Li et al.
Recent associations between Major Depressive Disorder (MDD) and measures of premature aging suggest accelerated biological aging as a potential biomarker for MDD susceptibility or MDD as a risk factor for age-related diseases. Residuals or ...
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed [0.03%]
衰老狒狒前额皮质线粒体生物能量学的性别特异性下降与行走速度有关
Daniel A Adekunbi,Hillary F Huber,Gloria A Benavides et al.
Daniel A Adekunbi et al.
Mitochondria play a crucial role in brain homeostasis and changes in mitochondrial bioenergetics are linked to age-related neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. We investigated changes in the act...