Age-related differences in the impact of background noise on neural speech tracking [0.03%]
背景噪声对不同年龄段人群言语信号神经追踪的影响差异研究
Björn Herrmann
Björn Herrmann
Tracking the envelope of speech in the brain is important for speech comprehension. Recent research suggests that acoustic background noise can enhance neural speech tracking, enabling the auditory system to robustly encode speech even unde...
Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age [0.03%]
小鼠随年龄增长信号囊泡的轴突运输及依赖BDNF的调节出现障碍
David Villarroel-Campos,Elena R Rhymes,Andrew P Tosolini et al.
David Villarroel-Campos et al.
A healthy nervous system is reliant upon an efficient transport network to deliver essential cargoes throughout the extensive and polarised architecture of neurons. The trafficking of cargoes, such as organelles and proteins, is particularl...
Modifiable risk factor profiles moderate the effect of β-amyloid pathology on cognition in aging [0.03%]
可修改危险因素谱型通过β淀粉样蛋白病理生理学影响衰老期认知功能
Mohini Bhade,Stefania Pezzoli,Joseph Giorgio et al.
Mohini Bhade et al.
Although modifiable risk factors may account for around 40 % of population variability in dementia risk, the effect of risk factor interrelationships on pathology-cognition relationships is poorly understood. Using risk factor data from a c...
Longitudinal relationships among cerebrospinal fluid biomarkers, cerebral blood flow, and grey matter volume in individuals with a familial history of Alzheimer's disease [0.03%]
携带阿尔茨海默病家族史个体中脑脊液生物标志物、脑血流和灰质体积的纵向关系研究
Safa Sanami,Brittany Intzandt,Julia Huck et al.
Safa Sanami et al.
Alzheimer's disease (AD) is a complex disease that involves complex interactions between protein biomarkers such as amyloid beta (Aβ) and tau, neurodegeneration, cerebrovascular health and inflammation. However, how these factors interact,...
Influence of sleep and cardiovascular health on cognitive trajectories in older adults [0.03%]
睡眠和心血管健康对老年人认知轨迹的影响
Hannah R Maybrier,Joshua J Jackson,Cristina D Toedebusch et al.
Hannah R Maybrier et al.
Age-related changes in sleep have been associated with cognitive decline, yet causal pathways have not been identified. Evidence suggests reduced cardiovascular health may be a consequence of poor sleep and a precursor to cognitive decline....
Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease [0.03%]
羊的早老素1半合子无明显的有害表型：阿尔茨海默病治疗靶点的潜在意义
Natasha E Mckean,Jun Liu,Skye R Rudiger et al.
Natasha E Mckean et al.
Alzheimer's disease (AD) is a neurodegenerative condition and one of the most significant medical challenges today. Dominant mutations causing early-onset AD have been identified in the presenilin 1 and 2 (PSEN1 and PSEN2), and the amyloid ...
Lower locus coeruleus integrity is associated with diminished practice effects in clinically unimpaired older individuals [0.03%]
黑质完整度较低与临床无损害老年人练习效应减弱有关
Lindsay F Smegal,Marion Baillet,Christoph Schneider et al.
Lindsay F Smegal et al.
The locus coeruleus (LC), one of the earliest structures affected by tau pathology in Alzheimer's disease (AD), plays an important role in modulating arousal and learning. In asymptomatic early stages of AD, more sensitive measures to ident...
Theta-gamma transcranial alternating current stimulation enhances ballistic motor performance in healthy young and older adults [0.03%]
theta- gamma 联合经颅交替电流刺激改善健康年轻人和老年人的离心运动性能
Nishadi N Gamage,Wei-Yeh Liao,Brodie J Hand et al.
Nishadi N Gamage et al.
Theta-gamma transcranial alternating current stimulation (TG tACS) over primary motor cortex (M1) can improve ballistic motor performance in young adults, but the effect on older adults is unknown. This study investigated the effects of TG ...
Calpain and caspase regulate Aβ peptide production via cleavage of KINDLIN2 encoded by the AD-associated gene FERMT2 [0.03%]
钙蛋白酶和半胱氨酸蛋白酶通过切割FERMT2基因编码的KINDLIN2调节淀粉样肽生成
Chloé Najdek,Pauline Walle,Amandine Flaig et al.
Chloé Najdek et al.
The adapter protein KINDLIN2, encoded by the Alzheimer's disease (AD) genetic risk factor FERMT2, was identified as a modulator of APP processing. KINDLIN2 directly interacts with APP to modulate its metabolism, and KINDLIN2 underexpression...
Alzheimer's disease cerebrospinal fluid biomarker levels and APOE genetic status are associated with hippocampal-cerebellar functional connectivity [0.03%]
阿尔茨海默病脑脊液生物标志物和APOE基因状态与海马小脑功能连接相关性研究
Elizabeth R Paitel,Corinne Pettigrew,Abhay Moghekar et al.
Elizabeth R Paitel et al.
Recent research suggests that hippocampal-cerebellar (Hp-CB) functional connectivity may be altered early in the course of Alzheimer's disease (AD), given the early accumulation of AD pathology in the hippocampi and emerging evidence of cer...