White matter hyperintensities contribute to early cortical thinning in addition to tau in aging [0.03%]
白质高信号除tau蛋白外因还贡献于老年人大脑皮层变薄现象
Riccardo Leone,Xenia Kobeleva;Alzheimer&#x;s Disease Neuroimaging Initiative
Riccardo Leone
White matter hyperintensities (WMH) are associated with cortical thinning in distant brain regions. However, it is currently unclear how WMH affect neurodegeneration in early Alzheimer's disease (AD). Here, we investigated associations betw...
Integrating plasma, MRI, and cognitive biomarkers for personalized prediction of decline across cognitive domains [0.03%]
结合等离子体、MRI和认知生物标志物进行跨认知领域的个性化衰退预测
Elaheh Moradi,Robert Dahnke,Vandad Imani et al.
Elaheh Moradi et al.
Plasma biomarkers are associated with cognitive performance and decline in Alzheimer's disease, making them promising for early detection. This study investigates their predictive value, combined with non-invasive measures, in forecasting c...
2988Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores [0.03%]
基于多组学的阿尔茨海默病基因型风险评分的细胞类型特异性分析
Nicholas O&#x;Neill,Nuzulul Kurniansyah,Congcong Zhu et al.
Nicholas O&#x;Neill et al.
Alzheimer disease (AD) polygenic risk scores (ADPRS) built from cell-type (ct) specific genetic variants can be used to infer cell-type contributions to AD. We derived two ct-ADPRSs using variants near single-nuclei RNA-seq (snRNA) derived ...
Repeated brain MRI utility in identifying neurodegenerative disorders at the pre-dementia stage [0.03%]
重复脑MRI在前痴呆阶段识别神经退行性疾病的效用
Chiara Carbone,Chiara Gallingani,Erica Balboni et al.
Chiara Carbone et al.
Despite the increasing availability of biomarkers in clinical settings, diagnosing individuals with subtle cognitive/behavioral symptoms and normal structural brain imaging remains challenging. In real-world settings, it is not feasible to ...
Blood oxygenation level-dependent responses in neuromodulatory nuclei and their associations with attention and memory across age groups [0.03%]
神经调节核的血氧水平依赖性反应及其在不同年龄段与注意力和记忆力的相关性
Elizabeth Riley,Nicholas Cicero,Khena Swallow et al.
Elizabeth Riley et al.
Using multi-echo blood oxygenation level-dependent (BOLD) neuroimaging, we examined lifespan differences in three subcortical nuclei important to the neuromodulation of cognition and target sites for early Alzheimer's pathogenesis in the is...
Comparison of CSF neurofilament light chain and total tau as neurodegeneration markers: Associations with synaptic markers and cognitive outcomes [0.03%]
神经丝轻链和总tau作为神经退行性标志物的比较：与突触标志物和认知结果的关系
Grit Richter,Bjørn-Eivind Kirsebom,Jonas Alexander Jarholm et al.
Grit Richter et al.
Clinically, Alzheimer's disease (AD) is characterized by progressive cognitive decline due to neuronal and synaptic degeneration. Neurofilament light chain (NfL) and total tau (T-tau) reflect neurodegeneration, NfL putatively more related t...
Epigenetic age is associated with regional brain aging along the sensorimotor-to-association axis of cortical organization [0.03%]
表观遗传年龄与皮层组织的感觉运动至关联轴的脑区域衰老有关
Nicholas Riccardi,Carolyn Banister,Natalie Busby et al.
Nicholas Riccardi et al.
Brain age and epigenetic age (DNAmAge) are 'biological clocks' independently linked to health outcomes. However, the relationship between brain and epigenetic age remains unclear. We used path analysis to investigate relationships between c...
Serum HDL-cholesterol is associated with the clinical-biological profile of early-stage Parkinson's disease patients independently of APOE [0.03%]
载脂蛋白E独立的高密度脂蛋白胆固醇与早期间质性帕金森病患者的临床生物学特征相关
Davide Mascioli,Matteo Conti,Jacopo Bissacco et al.
Davide Mascioli et al.
Emerging evidence highlights a possible interplay between serum lipid profiles and Parkinson's disease (PD), but the biological underpinnings remain largely unexplored. In this cross-sectional study, we investigated whether serum lipid leve...
Evaluating the link between hearing loss and Alzheimer's disease neuropathology: A systematic review and meta-analysis [0.03%]
听觉丧失和阿尔茨海默病神经病理学之间联系的系统评价和meta分析
Avinash Chandra,Benjamin A Levett,Sheena Waters et al.
Avinash Chandra et al.
Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not clear. In this systematic review and meta-analysis, we evaluated associations between heari...
Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults [0.03%]
识别出区分记忆轨迹的生活方式风险因素：老年群体中不同种族和族裔组的差异发现
Shraddha Sapkota,Pauline Maillard,Evan M Fletcher et al.
Shraddha Sapkota et al.
Introduction: Differences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We identifieded lifestyle risk factors that best discriminat me...