Frontoparietal functional dedifferentiation during naturalistic movie watching among older adults at risk of emotional vulnerability [0.03%]
老年人在观看电影时前额叶功能去分化与情绪脆弱性风险之间的关系研究
Shuer Ye,Arjun Dave,Alireza Salami et al.
Shuer Ye et al.
Functional dedifferentiation, a hallmark of brain aging particularly evident within the frontoparietal network (FPN), has been extensively investigated in the context of cognitive decline, yet its implications for late-life mental health re...
Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults [0.03%]
与老年人皮质厚度和认知相关的体内动脉粥样硬化(ARTS)分类器协会研究
Alifiya Kapasi,Maude Wagner,Arnold M Evia et al.
Alifiya Kapasi et al.
Brain arteriolosclerosis, a prominent small vessel pathology in the aging brain, is associated with cognitive impairment. Understanding the link between arteriolosclerosis and neurodegeneration may be crucial towards unravelling pathways by...
Cognitive resilience in preclinical Alzheimer's disease: Higher NPTX2 and VGF levels are associated with reduced cognitive decline [0.03%]
轻度认知障碍和阿尔茨海默病前期的认知韧性：NPTX2和VGF水平较高与认知衰退减少有关
Claire L Anderson,Alden L Gross,Corinne Pettigrew et al.
Claire L Anderson et al.
Prior work suggests higher levels of the synaptic proteins neuronal pentraxin 2 (NPTX2) and neurosecretory protein VGF (VGF) may confer cognitive resilience to Alzheimer's disease (AD) pathology. Little is known about how these measures rel...
Corrigendum to "The moderating effect of cognitive reserve on the association between neuroimaging biomarkers and cognition: A systematic review" [Neurobiology of Aging, Volume 156, December 2025, Pages 10-29] [0.03%]
关于“认知储备对神经影像生物标志物与认知关联的调节作用系统回顾”的勘误[《衰老神经生物学》第156卷，2025年12月，第10-29页]
Lizhi Guo,Yajing Zhou,Hanna Lu et al.
Lizhi Guo et al.
A synthetic nonapeptide, JAL-TA9, inhibits neuronal cytotoxicity caused by Aβ25-35 aggregation with proteolytic activity [0.03%]
合成非肽JAL-TA9通过蛋白水解作用抑制Aβ25-35聚集引起的神经元细胞毒性
Rina Nakamura,Momoka Okada,Asuka Takahashi et al.
Rina Nakamura et al.
Due to the growing number of Alzheimer's disease (AD) patients, new drugs are urgently required. A synthetic nonapeptide, JAL-TA9 (YKGSGFRMI), derived from Transducer of ErbB-2.1 (Tob1) protein, cleaves amyloid β (Aβ) 42 with serine prote...
Aging-related adaptations of metabotropic glutamate receptors within the CA3 region of the rat hippocampus [0.03%]
大鼠海马CA3区代谢型谷氨酸受体的老化适应性变化
Emilio J Galván,Ernesto Griego
Emilio J Galván
The physiological decline associated with aging is often accompanied by a progressive deterioration in cognitive processing abilities driven by a series of cellular dysfunctions that remain poorly understood. In the hippocampus, a critical ...
Qingyu Zhao,Natalie M Zahr
Qingyu Zhao
Normative, longitudinal data are necessary for effective modeling of factors underlying disease processes on the brain. Large scale national and international consortium data have characterized human regional brain volume trajectories as co...
Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss [0.03%]
两种加速衰老小鼠模型中内毛细胞突触病变与外毛细胞丢失的关系研究
Tuuli Lankinen,Saija Leinonen,Kuu Ikäheimo et al.
Tuuli Lankinen et al.
Hallmarks of sensorineural hearing loss are elevated hearing thresholds and defects in temporal auditory processing, the former being often caused by outer hair cell (OHC) damage, and the latter by the loss of synapses between inner hair ce...
Age-associated trajectories of hippocampus subregion volumes from childhood through later adulthood [0.03%]
从儿童期到老年期海马亚区体积的年龄相关轨迹
Suril Gohel,Chi C Chan,Isabelle Baptista et al.
Suril Gohel et al.
The hippocampus has been widely implicated in the neurobiology of neurologic and psychiatric disorders. This structure is heterogeneous, however, and comprised of multiple subregions that have different connectivity patterns and functions. ...
The relationship between racial discrimination and white matter among Black older adults [0.03%]
种族歧视与黑人老年人的白质之间的关系
Jordan D Palms,Ji Hyun Lee,Emily P Morris et al.
Jordan D Palms et al.
Black older adults experience worse brain and cognitive aging than White older adults, on average. Racially patterned psychosocial stressors may contribute to these disparities. Maintaining white matter health is important for cognitive agi...