Robert C Owens Jr
Robert C Owens Jr
Critical-care units can be barometers for appropriate antimicrobial use. There, life and death hang on empirical antimicrobial therapy for treatment of infectious diseases. With increasing therapeutic empiricism, triple-drug, broad-spectrum...
David J Ritchie,Bryan T Alexander,Patrick M Finnegan
David J Ritchie
Timely provision of adequate antimicrobial coverage in an initial anti-infective treatment regimen results in optimal outcomes for bacterial and fungal infections. However, selection of appropriate antimicrobial regimens for treatment of in...
Jay R McDonald
Jay R McDonald
Acute infective endocarditis is a complex disease with changing epidemiology and a rapidly evolving knowledge base. To consistently achieve optimal outcomes in the management of infective endocarditis, the clinical team must have an underst...
Marya D Zilberberg,Andrew F Shorr
Marya D Zilberberg
Pulmonologists and intensivists often care for patients at risk for infections caused by both Aspergillus and Candida. Infection with either can lead to severe life-threatening disease, particularly in immunosuppressed patients, with mortal...
Hitoshi Honda,David K Warren
Hitoshi Honda
Despite advances in antimicrobial and antiviral therapy, meningitis and brain abscess are infections that result in significant morbidity and mortality. A multidisciplinary approach, including intensive care, is often required in the treatm...
Joseph S Solomkin,John Mazuski
Joseph S Solomkin
Complicated intra-abdominal infections are the second most common cause of septic death in the intensive care unit. Although there have been improvements in the outcome of sepsis regardless of etiology, this is even more striking for intra-...
Lena M Napolitano
Lena M Napolitano
Severe skin and soft tissue infections (SSTIs) frequently require management in the ICU, in part related to associated septic shock or toxic shock syndrome or associated organ failure. Four fundamental management principles are key to a suc...
Jordi Vallés,Ricard Ferrer
Jordi Vallés
Hospital-acquired infections (HAI) occur in 5%-10% of patients admitted to hospitals in the United States, and HAIs remain a leading cause of morbidity and mortality. Patients admitted to ICUs account for 45% of all hospital-acquired pneumo...
Approach to the immunocompromised host with infection in the intensive care unit [0.03%]
重症监护病房免疫功能低下的感染患者的处理方法
Peter K Linden
Peter K Linden
Despite significant advances in the prevention, diagnosis, and treatment of infection in the immunocompromised host, it remains a major cause of morbidity, increased length of stay, total costs, and of course mortality. Intensive care morta...
Emili Diaz,Marta Ulldemolins,Thiago Lisboa et al.
Emili Diaz et al.
Ventilator-associated pneumonia (VAP) management depends on the interaction between the infective agent, the host response, and the antimicrobial drug used. After the pathogen reaches the lungs, two outcomes are possible: either the microor...