Current Management Strategies of Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections [0.03%]
难治性铜绿假单胞菌感染的当前管理策略
Juan P Horcajada,Maria-Milagro Montero,Sonia Luque et al.
Juan P Horcajada et al.
Difficult-to-treat resistant (DTR) Pseudomonas aeruginosa is an important cause of severe health care-associated infections and is associated with high morbidity and mortality. Its complex resistance mechanisms compromise the efficacy of tr...
Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management [0.03%]
应对金黄色葡萄球菌血流感染挑战的实际管理指南
Hadar Mudrik-Zohar,Sean W X Ong,Todd C Lee et al.
Hadar Mudrik-Zohar et al.
Staphylococcus aureus bacteremia (SAB) continues to challenge clinicians with its' diverse clinical presentations, risk of complications, and high mortality rate. While foundational principles of management, such as adequate source control ...
The Transmission of Clostridioides (Clostridium) difficile with a One Health Perspective [0.03%]
具有一体健康视角的难辨梭菌（梭菌）传播研究进展
Su-Chen Lim,Thomas V Riley
Su-Chen Lim
Clostridioides difficile infection is a significant public health concern traditionally linked to health care settings. However, genomic evidence increasingly supports the spread of C difficile across humans, animals, food, and the environm...
Advances in Understanding the Pathogenesis of Clostridioides difficile Infection [0.03%]
艰难梭菌感染发病机制的研究进展
Anna M Seekatz,Michael C Abt
Anna M Seekatz
Clostridioides difficile infection (CDI) remains a significant cause of infectious colitis in the United States. Susceptibility to CDI is associated with perturbation of the gut microbiota, the indigenous microbes in the gastrointestinal tr...
Parul Berry,Sahil Khanna
Parul Berry
This article offers a clinically focused overview of Clostridioides difficile infection (CDI) diagnosis, emphasizing the need to test only symptomatic patients and to distinguish true infection from colonization. It reviews multistep diagno...
Alice Y Guh,L Clifford McDonald
Alice Y Guh
This article describes the epidemiology of Clostridioides difficile infection (CDI) by outlining common approaches to CDI surveillance, including the application of a case definition and risk adjustment, and summarizing recent global trends...
Predictive Modeling for Clostridioides difficile Infection: Current State of the Science, Clinical Applications, and Future Directions [0.03%]
预测建模在难辨梭菌感染中的应用：科学研究的现状、临床应用及未来方向
Krishna Rao,Jenna Wiens
Krishna Rao
Despite 2 decades of effort, there is a lack of clinically deployed models for predicting incident, severe, or recurrent Clostridioides difficile infection (CDI). This review outlines the promise of machine learning and biomarker-augmented ...
Evan S Snitkin
Evan S Snitkin
Clostridioides difficile is the most common cause of health care-associated infections in the United States. The persistence of C difficile as a significant cause of morbidity and mortality is a testament to significant gaps remaining in ou...
Nirja Mehta,Colleen Kraft,Stuart Johnson
Nirja Mehta
Clostridioides difficile medical management has changed significantly over the past decade with emphasis on preventing recurrent infection. This review compares current guidelines on the treatment of initial, recurrent, fulminant, and pedia...
Jared Salrin,David B Stewart
Jared Salrin
Clostridioides difficile infection (CDI) severe enough to potentially require surgery represents a minority of patients with CDI. This cohort of individuals is characterized by severe sepsis with organ failure, despite the use of appropriat...