Brett Gilbert,Paul Robbins,Lawrence L Livornese Jr
Brett Gilbert
This article provides background information on the pharmacokinetics of antibacterial agents in patients who have normal and impaired renal function. Tables are provided to allow quick determination of appropriate dosages for varying degree...
Stephen Weber,Emily Mawdsley,Donald Kaye
Stephen Weber
Older patients disproportionately suffer the burden of infection in the community and in health care facilities. The rational approach to antimicrobial therapy for older patients with infection requires an appreciation and understanding of ...
Susana Chavez-Bueno,Terrence L Stull
Susana Chavez-Bueno
Antibiotics are among the most frequently used drugs in children. Although antibacterials have been available for decades, many agents have not been studied to assess their safety and efficacy in the pediatric population. This article descr...
Deverick J Anderson,Keith S Kaye
Deverick J Anderson
Most evidence-based methods to control the spread of antimicrobial resistance have been developed and applied to the hospital setting. Strategies to control the emergence and spread of antimicrobial resistance in hospitals can be categorize...
Luke F Chen,Teena Chopra,Keith S Kaye
Luke F Chen
Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. ...
Matthew E Levison,Julie H Levison
Matthew E Levison
This article reviews pharmacodynamics of antibacterial drugs, which can be used to optimize treatment strategies, prevent emergence of resistance and rationalize the determination of antimicrobial susceptibility. Important pharmacodynamic c...
Thomas L Holland,Christopher W Woods,Maria Joyce
Thomas L Holland
This article familiarizes the clinician with the principles of bacterial susceptibility testing and reporting to facilitate communication with the clinical microbiology laboratory. As resistance continues to emerge among a wide range of cli...
Keith S Kaye,Donald Kaye
Keith S Kaye
David J Riddle,Erik R Dubberke
David J Riddle
Clostridium difficile infection (CDI) is becoming more common worldwide. The morbidity and mortality associated with C difficile is also increasing at an alarming rate. Critically ill patients are at particularly high risk for CDI because o...
Mary C Barsanti,Keith F Woeltje
Mary C Barsanti
Hospital-acquired infections have profound social, economic, and personal costs to patients in the intensive care unit (ICU). Numerous risk factors, such as poor nutrition and hyperglycemia, directly involve patients. Meanwhile, hand hygien...