Alaina S Ritter,Simon Mears
Alaina S Ritter
The prevention of orthopedic infections is of critical importance to improve patient outcomes and reduce health care costs. Preventative strategies can be employed preoperatively, including mitigation of medical risk factors, methicillin-re...
Rajesh T Gandhi,Michael R Jordan
Rajesh T Gandhi
Models of Musculoskeletal Infection Care: The Importance of Multidisciplinary Collaboration [0.03%]
骨与关节感染的治疗模式：多学科协作的重要性
Alexander M Tatara,Antonia F Chen,F Joseph Simeone et al.
Alexander M Tatara et al.
Musculoskeletal infections are increasing in incidence and complexity. There is mounting evidence that formal models of multidisciplinary care improve patient outcomes in severe infection. In this study, we review different published models...
Sabina Herrera,Ursula Magyar,Shahid Husain
Sabina Herrera
Despite significant advances, aspergillosis remains a critical health concern, with an evolving epidemiology and expanding populations of at-risk patients. Historically, fewer than 10 Aspergillus species were considered clinically significa...
Pelvic Osteomyelitis [0.03%]
骨盆骨髓炎
Jakrapun Pupaibool,Justin Haller
Jakrapun Pupaibool
Pelvic osteomyelitis is a challenging infection often caused by contiguous spread, direct inoculation, or hematogenous dissemination, with key risk factors including trauma, surgery, radiation, and intra-abdominal or genitourinary infection...
Fracture-Related Infections [0.03%]
与骨折相关的感染
Jessica Seidelman,Malcolm DeBaun
Jessica Seidelman
Fracture-related infections are challenging complications in orthopedic care, marked by infection at fracture or surgical sites, often involving biofilm-associated pathogens. They result in significant morbidity, prolonged hospitalizations,...
Melissa D Johnson,W Justin Moore
Melissa D Johnson
Prevention and management of invasive fungal infections is challenging due to the complexity of at-risk patient population, high morbidity and mortality of these infections, and pharmacologic aspects of available antifungal agents. While th...
Next-Generation Coronavirus Disease 2019 Vaccines: Clinical Data and Future Directions [0.03%]
下一代冠状病毒疾病2019疫苗：临床数据与未来方向
Kathryn E Stephenson
Kathryn E Stephenson
Current coronavirus disease 2019 (COVID-19) vaccines have prevented millions of deaths since the beginning of the pandemic. Yet, current vaccines have critical limitations: (1) they elicit poor mucosal immune responses with reduced protecti...
Severe Acute Respiratory Syndrome Coronavirus 2 Immunology and Coronavirus Disease 2019 Clinical Outcomes [0.03%]
SARS冠状病毒2的免疫学与COVID-19的临床结果
Aljawharah Alrubayyi,Hsinyen Huang,Gaurav D Gaiha
Aljawharah Alrubayyi
The humoral and cellular immune response are the key players in preventing viral infection and limiting disease severity, particular in the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus di...
Amy Hirsch Shumaker,Adarsh Bhimraj
Amy Hirsch Shumaker
Widespread vaccination, hybrid immunity, and reduced pathogenicity with circulating Omicron variants have decreased the rate of severe coronavirus disease 2019 (COVID-19) outcomes in the general population. Certain patients with COVID-19 re...