Predictive Modeling for Clostridioides difficile Infection: Current State of the Science, Clinical Applications, and Future Directions [0.03%]
预测建模在难辨梭菌感染中的应用：科学研究的现状、临床应用及未来方向
Krishna Rao,Jenna Wiens
Krishna Rao
Despite 2 decades of effort, there is a lack of clinically deployed models for predicting incident, severe, or recurrent Clostridioides difficile infection (CDI). This review outlines the promise of machine learning and biomarker-augmented ...
Evan S Snitkin
Evan S Snitkin
Clostridioides difficile is the most common cause of health care-associated infections in the United States. The persistence of C difficile as a significant cause of morbidity and mortality is a testament to significant gaps remaining in ou...
Nirja Mehta,Colleen Kraft,Stuart Johnson
Nirja Mehta
Clostridioides difficile medical management has changed significantly over the past decade with emphasis on preventing recurrent infection. This review compares current guidelines on the treatment of initial, recurrent, fulminant, and pedia...
Jared Salrin,David B Stewart
Jared Salrin
Clostridioides difficile infection (CDI) severe enough to potentially require surgery represents a minority of patients with CDI. This cohort of individuals is characterized by severe sepsis with organ failure, despite the use of appropriat...
Immune Aspects of Clostridioides difficile Infection and Vaccine Development [0.03%]
艰难梭菌感染的免疫学特征及其疫苗研发进展
Rochelle C Glover,F Christopher Peritore-Galve,Borden Lacy et al.
Rochelle C Glover et al.
Clostridioides difficile causes antibiotic-associated diarrhea and pseudomembranous colitis. The pathogenesis of C difficile infection is driven by 2 exotoxins, TcdA and TcdB, making them priority targets for therapeutic intervention. Sever...
In vitro and in Vivo Models for Understanding Clostridioides difficile [0.03%]
体外和体内模型在了解艰难梭状芽孢杆菌中的应用
Jennifer M Auchtung
Jennifer M Auchtung
Several in vitro and in vivo models have been developed for characterizing Clostridioides difficile infection and disease. Syrian hamster and mouse models are the primary in vivo models of infection. Invertebrate animals and in vitro approa...
Christine W Lucky,Brendan J Kelly,Jennie H Kwon et al.
Christine W Lucky et al.
Microbiota-based therapies are used increasingly for the treatment and prevention of Clostridioides difficile infection (CDI), particularly in cases of recurrent CDI (rCDI). This review discusses the different types of microbiota-based ther...
Kanika Sehgal,Paul Feuerstadt,Mark H Wilcox
Kanika Sehgal
The Clostridioides difficile infection (CDI) epidemic has been impacting the world for years. Understanding accurate diagnostics is imperative to allow the appropriate patients to be treated and improve outcomes. This article leverages mult...
Jesse Vance,Nicholas A Turner
Jesse Vance
Clostridioides difficile prevention is challenging as spores are highly resilient and transmission sources diverse. Hand hygiene, contact precautions, and environmental decontamination are fundamental infection prevention strategies. Antimi...
Larry K Kociolek,Thomas J Sandora,Preeti Mehrotra
Larry K Kociolek
After a significant increase in pediatric Clostridioides difficile infection (CDI) in the United States over the past 2 decades, incidence has declined over the past 5 y. Community-associated CDI incidence is 3 times higher than healthcare ...