Strategic Demonstration of the Clinical Utility of Nontraditional Antibacterials [0.03%]
非传统抗菌药物临床价值的战略展示
Neha Prasad,Sumati Nambiar
Neha Prasad
Antimicrobial stewardship (AMS) interventions have curbed antibiotic misuse, paradoxically restricting market adoption of new antibiotics in the process. This review critically examines non-traditional approaches to manage bacterial infecti...
David L Paterson
David L Paterson
Ya-Ting Chang,Po-Liang Lu,David L Paterson
Ya-Ting Chang
Optimal therapeutic strategies for Stenotrophomonas maltophilia infections remain largely undefined. Current evidence tentatively supports combination therapy in immunocompromised hosts and severe infections, as no single agent reliably pro...
Antimicrobial Management Strategies for Multidrug-Resistant Gram-positive Prosthetic Device Infections [0.03%]
抗多重耐药革兰阳性定植装置感染的抗菌管理策略
Burcu Isler,Peter Simos,Victoria Grey et al.
Burcu Isler et al.
Prosthetic device infections caused by multidrug-resistant (MDR) gram-positive bacteria pose significant therapeutic challenges. This review examines management strategies for methicillin-resistant staphylococci, ampicillin-resistant entero...
Current Management Strategies of Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections [0.03%]
难治性铜绿假单胞菌感染的当前管理策略
Juan P Horcajada,Maria-Milagro Montero,Sonia Luque et al.
Juan P Horcajada et al.
Difficult-to-treat resistant (DTR) Pseudomonas aeruginosa is an important cause of severe health care-associated infections and is associated with high morbidity and mortality. Its complex resistance mechanisms compromise the efficacy of tr...
Navigating the Challenges in Staphylococcus aureus Bloodstream Infection: A Practical Guide to Management [0.03%]
应对金黄色葡萄球菌血流感染挑战的实际管理指南
Hadar Mudrik-Zohar,Sean W X Ong,Todd C Lee et al.
Hadar Mudrik-Zohar et al.
Staphylococcus aureus bacteremia (SAB) continues to challenge clinicians with its' diverse clinical presentations, risk of complications, and high mortality rate. While foundational principles of management, such as adequate source control ...
The Transmission of Clostridioides (Clostridium) difficile with a One Health Perspective [0.03%]
具有一体健康视角的难辨梭菌（梭菌）传播研究进展
Su-Chen Lim,Thomas V Riley
Su-Chen Lim
Clostridioides difficile infection is a significant public health concern traditionally linked to health care settings. However, genomic evidence increasingly supports the spread of C difficile across humans, animals, food, and the environm...
Advances in Understanding the Pathogenesis of Clostridioides difficile Infection [0.03%]
艰难梭菌感染发病机制的研究进展
Anna M Seekatz,Michael C Abt
Anna M Seekatz
Clostridioides difficile infection (CDI) remains a significant cause of infectious colitis in the United States. Susceptibility to CDI is associated with perturbation of the gut microbiota, the indigenous microbes in the gastrointestinal tr...
Parul Berry,Sahil Khanna
Parul Berry
This article offers a clinically focused overview of Clostridioides difficile infection (CDI) diagnosis, emphasizing the need to test only symptomatic patients and to distinguish true infection from colonization. It reviews multistep diagno...
Alice Y Guh,L Clifford McDonald
Alice Y Guh
This article describes the epidemiology of Clostridioides difficile infection (CDI) by outlining common approaches to CDI surveillance, including the application of a case definition and risk adjustment, and summarizing recent global trends...