Current Management of Serious Infections due to Vancomycin-resistant Enterococci [0.03%]
万古霉素耐药肠球菌所致严重感染的目前管理方法
Sara I Gomez-Villegas,William R Miller,Cesar A Arias
Sara I Gomez-Villegas
Vancomycin-resistant enterococci (VRE) are major health care-associated pathogens and significantly contribute to patient morbidity and mortality, particularly in immunocompromised and critically ill patients. The clinical management of VRE...
Antimicrobial Stewardship for the Infection Control Professional: Mutual Collaboration for Mutual Benefit [0.03%]
感染控制专业人员的抗菌药物管理：相互协作以实现互惠益处
Marten R Hawkins,Jason Pogue,Shiwei Zhou
Marten R Hawkins
This article emphasizes the global threat of antimicrobial resistance, highlighting its origins, mechanisms, and widespread impact on patient care and public health. It discusses the consequences of suboptimal antibiotic use, including incr...
Treatment of Melioidosis [0.03%]
波状热的治疗
Ella M Meumann,Giri Rajahram,Stephen D Woolley et al.
Ella M Meumann et al.
Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative environmental saprophyte found in tropical and subtropical regions globally. The aims of treatment for melioidosis are to prevent death and other complications of septic sh...
How to Treat Carbapenem-Resistant Acinetobacter baumannii Infections: Current Knowledge and Personal Viewpoints [0.03%]
碳青霉烯耐药鲍曼不动杆菌感染的治疗：现有认识和观点
Antonio Cascio,Luca Pipitò,David L Paterson
Antonio Cascio
Acinetobacter baumannii, particularly carbapenem-resistant strains (CRAB), represents a critical global health threat due to its multidrug resistance and association with severe healthcare-associated infections. Treatment options remain lim...
Severe Bacterial Infections due to Multidrug-Resistant Organisms in Solid Organ Transplant Recipients [0.03%]
实体器官移植受者多重耐药菌所致严重细菌感染
Carlos A Portales Castillo,Ruben A Hernández Acosta,Adam G Stewart
Carlos A Portales Castillo
Solid organ transplant recipients (SOTr) are at increased risk of both becoming colonized and infected with multidrug-resistant organisms (MDROs) owing to diverse host, environment and exposure factors. Despite significant advances in surgi...
Therapeutic Strategies for Extended-Spectrum β-Lactamase-Producing Organisms: Carbapenem-Sparing and Oral Options [0.03%]
治疗产超广谱β内酰胺酶细菌的药物策略：碳青霉烯类药物节省型和口服型选项
Laura E Wilkins,Yohei Doi
Laura E Wilkins
Extended-spectrum β-lactamase (ESBL)-producing bacteria are increasingly common, especially in community settings of low-resource areas. While intravenous carbapenems are the most effective treatment, rising resistance highlights the impor...
Current Options for the Treatment of Invasive Infections Caused by Carbapenem-Resistant Enterobacterales [0.03%]
碳青霉烯耐药肠杆菌科细菌所致侵袭性感染的治疗选择
Jinghao Nicholas Ngiam,Matthew Chung Yi Koh,Grace Tung et al.
Jinghao Nicholas Ngiam et al.
Carbapenem-resistant enterobacterales (CRE) remain a major clinical and public health concern, with limited treatment options. Given the heterogeneity in resistance mechanisms, infection syndromes, and host factors, selecting optimal therap...
Abi Manesh S
Abi Manesh S
Hypervirulent Klebsiella pneumoniae (HvKp) is a highly invasive pathotype causing severe, community-acquired infections, unlike nosocomial classic K pneumoniae. First reported in 1986, HvKp is linked to liver abscess, bacteremia, and endoph...
Rapid Diagnostic Strategies for Antibiotic-Resistant Bacteria Causing Bloodstream Infection [0.03%]
防治耐药菌血流感染的快速诊断策略
Anna Maria Peri,Patrick N A Harris,Ritu Banerjee
Anna Maria Peri
Novel technologies for the diagnosis of bloodstream infection are emerging, with the potential to improve patient care. Antimicrobial stewardship programs have proven essential to embed such tests into clinical practice and thus support ear...
Current Antibiotic Options for the Treatment of Infections with AmpC-Producing Enterobacterales [0.03%]
治疗产AmpC酶肠杆菌目感染的抗生素选择
Jinghao Nicholas Ngiam,Matthew Chung Yi Koh,Patrick N A Harris et al.
Jinghao Nicholas Ngiam et al.
AmpC β-lactamases, found in certain Enterobacterales, confer resistance to third-generation cephalosporins, some β-lactam/β-lactamase inhibitor combinations, and cephamycins. They may be chromosomal or plasmid-mediated. Generally, third-...