The Prognostic Value of Immunohistochemical Biomarkers in Medullary Thyroid Carcinoma: A Systematic Review and Meta-Analysis [0.03%]
免疫组化生物标志物在髓样甲状腺癌预后价值的系统评价和meta分析
Leonoor E Schonebaum,Lindsey Oudijk,Merel Tessa Stegenga et al.
Leonoor E Schonebaum et al.
Background: The prognosis and disease course of medullary thyroid carcinoma (MTC) can vary widely among patients. Effective risk stratification is important for ensuring timely treatment and personalized follow-up. Biomarkers can enhance ri...
Core Outcome Set of the Surgical Treatment of Differentiated Thyroid Carcinoma: International Consensus by Delphi Study [0.03%]
分化型甲状腺癌手术治疗核心结局指标集：德尔菲国际共识研究
Daniël J van de Berg,Menno R Vriens,Hanneke M van Santen et al.
Daniël J van de Berg et al.
Background: No international consensus exists on the selection and reporting of outcomes after differentiated thyroid cancer (DTC) surgery, hindering assessment of new treatments and guideline formation. Therefore, we aimed to develop an in...
Thyroid Hormones Act as a Timer for the Postnatal Maturation of Parvalbumin Neurons in Mouse Neocortex [0.03%]
甲状腺激素作为小鼠大脑皮层_parvalbumin神经元_产后成熟的计时器
Juan Ren,Suzy Markossian,Romain Guyot et al.
Juan Ren et al.
Background: A finely tuned balance between excitation and inhibition is essential for proper brain function. Disruptions in the GABAergic system, which alter this equilibrium, are a common feature in various types of neurological disorders....
Survival Outcomes and Treatment Strategies in Primary Thyroid Lymphoma: A Population-Based Study of 401 Cases from the Tokyo Cancer Registry [0.03%]
东京癌症登记局401例原发性甲状腺淋巴瘤的生存结局及治疗策略：基于人口的调查研究
Yoshiyuki Saito,Natsuko Watanabe,Kosuke Inoue et al.
Yoshiyuki Saito et al.
Background: There is limited information about the clinical behavior and no standardized treatment guidelines for primary thyroid lymphoma (PTL). Prognostic factors and treatment outcomes remain poorly defined despite diagnostic and therape...
Free T4 Age-Specific Reference Intervals from Birth to the 10th Decade of Life Using Direct Dialysis [0.03%]
直接使用透析法测定出生至第十个生命十年的游离T4年龄参考区间
Caixia Bi,Emily I Schindler,Ethan M Li et al.
Caixia Bi et al.
Background: Free thyroxine (FT4) reference intervals (RIs) provided by many laboratories do not adequately represent the differences in FT4 levels observed across age groups, limiting their usefulness in the diagnosis and management of dise...
Local Thyroid Hormone Activation or Inactivation by Deiodinases Regulates Intestinal Remodeling and Tail Resorption during Xenopus Metamorphosis [0.03%]
蛙变态过程中，由脱碘酶介导的局部甲状腺激素活化或失活调节肠道重塑和尾部吸收
Yuki Shibata,Kenta Fujimoto,Takashi Hasebe
Yuki Shibata
Background: Amphibian metamorphosis involves dramatic tissue remodeling, such as intestinal remodeling and tail resorption, driven by thyroid hormones (THs). Among these hormones, T3, the major active form of TH, is locally generated from T...
Preliminary Evidence of Potential Association Between Exposure to Estriol-Containing Skincare Cosmetics Sold in China and Autoimmune Thyroid Disease [0.03%]
含雌三醇护肤品暴露与中国女性自身免疫性甲状腺疾病发病关联的前瞻性队列研究初步分析
Lanchun Liu,Chunhu Li,Chang Liu et al.
Lanchun Liu et al.
Background: Estrogen may contribute to a higher prevalence of autoimmune thyroid disease (AITD) in women. However, it is unknown whether estrogen-containing cosmetics may be associated with AITD. This study aimed to (1) measure the estrogen...
Genetic Rescue of a Subset of Thyroid Follicular Cells Restores Thyroid Function in Dyshormonogenic Duoxa-/- Mice [0.03%]
遗传救援甲状腺滤泡细胞亚群可恢复Duoxa-/- 病理性促激素分泌小鼠的甲状腺功能
Sami Djerbib,Helmut Grasberger,Steven Goossens et al.
Sami Djerbib et al.
Background: Under sufficient iodine supply, dual oxidase (DUOX)-dependent H2O2 production constitutes the limiting factor for thyroid hormone (TH) synthesis. Inherited loss-of-function mutations in related genes can trigger congenital hypot...
Prognostic Thresholds for Lymph Node Metastasis in Medullary Thyroid Cancer: A Restricted Cubic Splines Analysis [0.03%]
基于限制性立方样条的甲状腺髓样癌淋巴结转移预后阈值分析
Christina V Lindsay,Frances Wang,Samantha M Thomas et al.
Christina V Lindsay et al.
Objectives: The current American Joint Committee on Cancer medullary thyroid cancer (MTC) staging system qualitatively stratifies lymph node (LN) status based on involved LN compartments; however, American Thyroid Association guidelines not...