Does Thyroid Hormone Boost Energy and Plasticity in the Brain as a Mechanism of Action in Antidepressant Augmentation Therapy? [0.03%]
Roger McIntyre,Sanjay J Mathew,Thomas S Scanlan
Roger McIntyre
Background: Depression is a large and expanding worldwide unmet clinical need that has proven difficult to treat. Thyroid hormone has been used clinically for decades as an augmentation therapy to first-line antidepressan...
Empirical Thyrotropin-Free Thyroxine Relationship Across the Thyrotropin Spectrum and Implications for Reference Intervals [0.03%]
不同促甲状腺激素水平下人游离甲状腺素的参考区间及其与促甲状腺激素的经验性关系
Toshihiko Kasahara
Toshihiko Kasahara
Background: The relationship between thyrotropin (TSH) and free thyroxine (FT4) is commonly assumed to be log-linear. However, this assumption may oversimplify hypothalamic-pituitary-thyroid axis regulation. Characterizin...
Diagnostic Yield of Thyroid Incidentaloma Evaluation and the Impact of Guideline Variability: Insights from a Retrospective Cohort Study [0.03%]
甲状腺偶然结节评估的诊断价值及指南变异的影响：一项回顾性队列研究的启示
Jeresa I A Willems,Daan J L van Twist,Kristy M Pickwell et al.
Jeresa I A Willems et al.
Introduction: Thyroid incidentalomas are lesions detected incidentally on imaging performed for unrelated indications. Determining which lesions warrant further evaluation to exclude malignancy introduces a dilemma: inten...
Real-World Efficacy and Safety of Lenvatinib and Sorafenib in Thyroid Cancer: A Retrospective, Propensity-Score-Matched Study [0.03%]
仑伐替尼和索拉非尼治疗甲状腺癌真实世界疗效及安全性的回顾性倾向性匹配研究
Max Kappenstein,Viktoria Florentine Koehler,Nadia Ninosu et al.
Max Kappenstein et al.
Background: Lenvatinib and sorafenib are multitargeted tyrosine kinase inhibitors (mTKIs) approved for the treatment of radioiodine-refractory thyroid cancer (TC). In the absence of direct comparative clinical trials, we ...
Prospective Predictors of Poor Emotional Functioning in Patients with Differentiated Thyroid Carcinoma [0.03%]
分化型甲状腺癌患者不良情绪功能的预后指标分析
Gerasimos P Sykiotis,Athina Mageiropoulou,Akram Al-Ibraheem et al.
Gerasimos P Sykiotis et al.
Background: The health-related quality of life (HRQoL) of patients with differentiated thyroid carcinoma (DTC), especially their mental health, can be compromised by various factors beyond disease prognosis and treatment ...
Menopause-Related Health Outcomes in Women with Differentiated Thyroid Carcinoma Receiving Long-Term TSH Suppression after Total Thyroidectomy [0.03%]
甲状腺切除术后长期促甲状腺激素抑制治疗的分化型甲状腺癌女性患者的更年期相关健康结局
Burcu Candemir,Safak Akın,Mustafa Candemir et al.
Burcu Candemir et al.
Background: There is uncertainty regarding whether thyroid-stimulating hormone (TSH) suppression therapy in postmenopausal women with differentiated thyroid cancer (DTC) is associated with menopause-specific health concer...
Preliminary Evidence of Microplastics in the Human Thyroid and Their Potential Association with Autoimmune Thyroiditis [0.03%]
微塑料进入人体甲状腺的初步证据及其与自身免疫性甲状腺炎的可能关联
Shi-Tong Yu,Jinrong Fu,Zihao Fan et al.
Shi-Tong Yu et al.
Background: Microplastics (MPs) have been identified in multiple human tissues and are increasingly implicated in systemic health risks. Their presence in the thyroid gland, however, remains unexamined. Autoimmune thyroid...
A Temporal Analysis of Surgical Management and Outcomes Following ATA Guideline Updates in Papillary Thyroid Carcinoma: A Real-World Cohort Study of 31,861 Patients in South Korea [0.03%]
韩国31,861例乳头状甲状腺癌患者的ATA指南更新后手术管理和结局的回顾性队列研究及时间趋势分析
Jae Sang Ryu,Eun Jin Kim,In A Lee et al.
Jae Sang Ryu et al.
Background: The American Thyroid Association (ATA) guideline revisions in 2009 and 2015 encouraged a shift toward less extensive surgery and reduced use of radioactive iodine (RAI) in the management of patients with low-r...
Teprotumumab-Associated Hyperglycemia: A Large-Scale Multinational Cohort Study [0.03%]
特舒妥单抗相关性高血糖症：一项大规模多国队列研究
Natan Lishinsky-Fischer,Rena Pollack,Zvi Gur
Natan Lishinsky-Fischer
Objective: Teprotumumab, a monoclonal antibody targeting the insulin-like growth factor-1 receptor, represents the first Food and Drug Administration (FDA)-approved treatment for thyroid eye disease (TED). However, hyperg...
CT-Free Quantitative Thyroid SPECT Based on Artificial Intelligence: A Prospective Multicenter Noninferiority Clinical Trial [0.03%]
基于人工智能的无CT定量甲状腺谱-照相机正电子发射断层扫描：一项前瞻性多中心非劣效性临床试验
Hyun Woo Chung,Sang-Geon Cho,Dongkyu Oh et al.
Hyun Woo Chung et al.
Background: Hybrid single-photon emission computed tomography (SPECT)/computed tomography (CT) is used for the differential diagnosis of thyrotoxicosis, but its dependence on CT and complex analysis remains debated. This ...