Inhibition of Soluble TNF Mitigates Traumatic Brain Injury as a Risk Factor for the Development of Amyloidogenic Proteins and Functional Deficits in 3xTg-AD Mice [0.03%]
可溶性肿瘤坏死因子的抑制作用可以降低脑外伤引起淀粉样蛋白生成及功能障碍（3xTg-AD小鼠模型）的风险
Chelsie N Poffenberger,Michelle M Taylor,Katelyn Larson et al.
Chelsie N Poffenberger et al.
Traumatic brain injury (TBI) is a well-known risk factor for dementia with Alzheimer's disease (AD), and there are no known therapies that can mitigate this risk. Pre-clinical studies demonstrate a temporary upregulation of amyloid beta (A...
Structural Injuries Are Associated with Better Emotional Well-being after Traumatic Brain Injury [0.03%]
颅脑损伤后的结构损伤与更好的情绪健康有关
Samuel B Snider,Hui Shi,Chiara Maffei et al.
Samuel B Snider et al.
Emotional disturbances are common after traumatic brain injury (TBI), yet the neuroanatomic basis of these sequelae remains unclear. We aimed to determine whether emotional well-being is associated with the extent and/or location of structu...
Brain State Entropy as a Marker of Injury Severity and Sedation Effects Following Traumatic Brain Injury [0.03%]
创伤性脑损伤后的脑状态熵作为损伤严重程度和镇静作用的标志
Emma-Jane Mallas,Nádia Moreira da Silva,Karl A Zimmerman et al.
Emma-Jane Mallas et al.
Traumatic brain injury disrupts large-scale brain networks. Dynamic functional connectivity captures time-varying network interactions from functional MRI (fMRI) and provides insights into the brain's dynamic patterns of integration and seg...
Intrathecal Recombinant Human Hepatocyte Growth Factor for Acute Cervical Spinal Cord Injury with AIS Grade A at 72 h Post-Injury: Phase III Study of Safety and Efficacy [0.03%]
伤后72小时AIS分级为A的急性颈椎脊髓损伤患者应用鞘内注射重组人肝细胞生长因子的安全性和有效性的III期临床研究
Kazuya Kitamura,Narihito Nagoshi,Osahiko Tsuji et al.
Kazuya Kitamura et al.
The acute management of traumatic spinal cord injury (SCI) continues to lack a universally accepted pharmacological intervention. We developed a novel therapeutic strategy, intrathecal administration of pharmaceutical recombinant human hepa...
Peripheral SBK1 and ADGRG5 as Biomarkers of Cell Adhesion Molecule-Associated Immune Alterations after Spinal Cord Injury [0.03%]
外周SBK1和ADGRG5作为脊髓损伤后细胞粘附分子相关免疫改变的生物标志物
Pan Hongxia,Ding Mingfu,Xie Fei et al.
Pan Hongxia et al.
Immune dysregulation is a central component of secondary injury processes following spinal cord injury (SCI). Cell adhesion molecules (CAMs) play key roles in leukocyte-endothelium interactions and neuroimmune communication after neurotraum...
Blood-Based Mechanistic Biomarkers Improve Prognostication of Functional Outcome After Mild Traumatic Brain Injury [0.03%]
基于血液的机制生物标志物可改善轻度脑外伤后功能预后的评估
Koen Visser,Myrthe E de Koning,Bram Jacobs et al.
Koen Visser et al.
Performance of currently available prognostic models for predicting incomplete functional recovery following mild traumatic brain injury (mTBI) is only modest. Blood-based biomarkers may improve model performance. In this study we aimed to ...
Social Determinants of Health and Symptomatic Recovery from Pediatric Concussion [0.03%]
儿科脑震荡的健康社会决定因素和症状恢复状况
Brian C Liu,Keith Owen Yeates,Ken Tang et al.
Brian C Liu et al.
Social determinants of health (SDoH) are the non-medical factors that influence an individual's health and well-being. This study aimed to examine the relationships between SDoH and post-concussion symptom severity in Canadian children. We ...
An Empirical Examination of the Aspen Consensus Criteria's Diagnostic Accuracy Using the Coma Recovery Scale-Revised Rating Scale Categories: A Rasch Co-Calibration Analysis [0.03%]
采用昏迷恢复量表-修订版分级评估阿斯彭共识标准的诊断准确性的一项实证研究：兰什共校准分析
Jennifer A Weaver,Alison M Cogan,Patricia Grady-Dominguez et al.
Jennifer A Weaver et al.
Patients with disorders of consciousness (DoC) are often misdiagnosed as being in a lower state of consciousness than they are, which can impede their access to care. Cut points for each state of consciousness on the Coma Recovery Scale-Rev...
Prospective Study on Effects of Sports Participation on Brain Injury versus Orthopedic Injury in the Adolescent Brain Cognitive Development Study [0.03%]
青少年脑认知发展研究中运动参与对未来脑损伤和骨科损伤影响的前瞻性研究
Wenjing Meng,Florin Vaida,Nicola L de Souza et al.
Wenjing Meng et al.
Youth sports are popular in the United States and provide many physical and social benefits for children. However, sports participation is also a major source of pediatric traumatic injuries, including mild traumatic brain injury (mTBI) and...
Participation in Professional American-Style Football and Suicide Mortality: 1979-2019 [0.03%]
参与美式橄榄球与自杀死亡率：1979-2019
Rachel Grashow,Niki Konstantinides,Benjamin C Anderson et al.
Rachel Grashow et al.
Despite strong associations established between head injury and mental health, studies of professional athletes exposed to head injury show reduced risk of suicide compared with general populations. We compared the risk of suicide among Nat...