Altered Vitamin D Receptor Expression in Apa-I (rs7975232) Allelic Variants-A Probable Risk Factor for Susceptibility to Hepatitis B Virus Infection and Disease Progression [0.03%]
APA-I多态性通过影响维生素D受体表达可能成为HBV易感及疾病进展的风险因素
Manash Jyoti Kalita,Simanta Kalita,Partha Pratim Das et al.
Manash Jyoti Kalita et al.
Vitamin D exerts its antiviral effect through vitamin D receptor (VDR)/retinoid X receptor-mediated host immunomodulation. Besides the downregulation of VDR expression, its polymorphism was also observed among hepatitis B virus (HBV)-positi...
Development of ELISA-Based Assay for Detection of SARS-CoV-2 Neutralizing Antibody [0.03%]
基于ELISA的检测SARS-CoV-2中和抗体方法的研发
K P Mishra,Mrinalini Singh,Deepika Saraswat et al.
K P Mishra et al.
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulates the plasma B cells to secrete specific antibodies against the viral antigen. However, not all antibodies can prevent the virus from entering the cells. T...
Comparison of Immunogenicity of Alum and MF59-Like Adjuvant Inactivated SARS-CoV-2 Vaccines Against SARS-CoV-2 Variants in Elderly Mice [0.03%]
铝佐剂和MF59-like佐剂灭活新冠疫苗对老年小鼠血清中和抗体抗新冠病毒变异株的交叉中和活性比较研究
Shuang Bai,Yanli Kang,Weixin Chen et al.
Shuang Bai et al.
The constant emergence of variants of concern (VOCs) challenges the effectiveness of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines over time. This is most concerning in clinically vulnerable groups, such as older adu...
Hepatitis B Virus Envelope Antigen and Hepatitis B Virus Surface Antigen Both Contribute to the Innate Immune Response During Persistent Hepatitis B Virus Infection [0.03%]
乙型肝炎病毒包膜抗原和表面抗原均参与慢性HBV感染的天然免疫反应
Jie-Min Zhang,Na-Ling Kang,Lu-Ying Wu et al.
Jie-Min Zhang et al.
This study aimed to investigate the changes of toll-like receptor 4 (TLR4), proinflammatory cytokine expression, hepatitis B virus surface antigen (HBsAg), and hepatitis B virus envelope antigen (HBeAg) expression as well as innate immune c...
Elevated Levels of Cytotoxicity, Cytokines, and Anti-SARS-CoV-2 Antibodies in Mild Cases of COVID-19 [0.03%]
轻症COVID-19患者中细胞毒性、细胞因子和抗SARS-CoV-2抗体的水平较高
Miguel A Fernández-Rojas,Guillermina Ávila,Mirza Romero-Valdovinos et al.
Miguel A Fernández-Rojas et al.
Current evidence shows higher production of cytokines and antibodies against severe acute respiratory coronavirus 2 (SARS-CoV-2) in severe and critical cases of Coronavirus Disease 2019 (COVID-19) in comparison with patients with moderate o...
Zhen Fan,Rui Chen,Wen Yin et al.
Zhen Fan et al.
Both absent in melanoma 2 (AIM2) and interferon-inducible protein 16 (IFI16) are intracellular innate immune receptors that recognize double-stranded DNA released during pathogenic infection, leading to the assembly of the inflammasome. The...
Expression and Clinical Significance of Peripheral Blood IL-17A, IL-22, Tim-3, and gal-9 in Children with Infectious Mononucleosis [0.03%]
儿童传染性单核细胞增多症外周血IL-17A、IL-22、Tim-3和Gal-9的表达及临床意义
Mengli Xu,Yuqin Li,Meng Cao et al.
Mengli Xu et al.
To investigate the expression and clinical significance of peripheral blood interleukin (IL)-17A, IL-22, T cell immunoglobulin molecule-3 (Tim-3), and galectin-9 (gal-9) in children with infectious mononucleosis (IM) caused by the Epstein-B...
Investigation of the Seroprevalence of Antimeasles Immunoglobulin G Antibody in Students at Shiraz University of Medical Sciences [0.03%]
伊朗设拉子医科大学学生麻疹抗体血清流行病学调查研究分析报告
Mohammad Kia,Fatemeh Nekooei,Amir Hossein Alipour et al.
Mohammad Kia et al.
Measles is an acute, highly contagious disease with a high mortality rate in children. Although vaccination has reduced measles incidence, outbreaks still occur. Therefore, in this study, we aimed to investigate the frequency of antimeasles...
In Vivo Evidence of Respiratory Syncytial Virus Persistence in a Subset of Pulmonary Dendritic Cells Following a Primary Infection [0.03%]
原发性呼吸道合胞病毒感染后肺树突状细胞中存在呼吸道合胞病毒 persistence 的实验证据
Angela M Fonceca,Jeff Lauzon-Joset,Naomi Scott et al.
Angela M Fonceca et al.
Respiratory syncytial virus (RSV) causes annual epidemics of infections affecting the whole population. In vitro, it has been shown to infect and persist in human dendritic cells (DCs) for prolonged periods. Initially persistence is associa...
Nanoadjuvants Produced by Advanced Nanochelating Technology in the Inactivated-Severe Acute Respiratory Syndrome Coronavirus-2 Vaccine Formulation: Preliminary Results on Cytokines and IgG Responses [0.03%]
先进的纳米螯合技术产生的纳米佐剂在灭活新型冠状病毒疫苗中的初步研究：细胞因子和IgG反应的研究结果
Somayeh Kalanaky,Saideh Fakharzadeh,Pegah Karimi et al.
Somayeh Kalanaky et al.
Despite the great success of vaccines in various infectious diseases, most current vaccines are not effective enough, and on the contrary, clinically approved alum adjuvants cannot induce sufficient immune responses, including a potent cell...