Comparative Analysis of Nucleocapsid- and Spike-Specific Isotype Humoral Immune Responses Following Natural SARS-CoV-2 Infection and Vaccination with Sinopharm, Sinovac, and AstraZeneca [0.03%]
国药、科兴和阿斯利康疫苗接种与自然感染后核衣壳蛋白和刺突蛋白特异性体液免疫反应的比较分析
Mohamed Hassan Nasraa,Dina Nadeem Abd-Elshafy,Rola Nadeem et al.
Mohamed Hassan Nasraa et al.
The diversity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine platforms and widespread natural exposure have created a complex landscape of humoral immunity requiring detailed characterization. Here, we compare nucle...
Causal Impact of Blood Cell Traits on the Risk of Herpes Zoster: A Two-Sample Mendelian Randomization Study Based on Exogenous Stimulation Data [0.03%]
基于外源刺激数据的两样本孟德尔随机化研究血细胞特征对带状疱疹风险的因果影响
Dongxiao Li,Junhong Gan,Lin Xiao et al.
Dongxiao Li et al.
Background:Herpes zoster (HZ) is a common neurotropic infectious disease caused by the reactivation of varicella-zoster virus (VZV), primarily triggered by declining host immune function. While circulating immune cells play key roles in ant...
Utilization of Similar Epitopes to Develop Viral Vaccines that Produce Lifelong Immunity [0.03%]
利用相似表位开发能产生终生免疫的病毒疫苗
Xin-Yue Yang,Yu-Fan Fu,Lin-Bei Xie et al.
Xin-Yue Yang et al.
The half-life (HL) of specific antibodies produced by the human body against various viruses varies from about 4 months to 11,000 years. Due to their short half-lives, multiple-dose vaccinations and annual revaccination are usually required...
Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines [0.03%]
重链 reassortant 展现上皮癌细胞系中的环境依赖性溶瘤表型
J Ryder Hutchinson,Owen M Carter,Charlotte V Dagli et al.
J Ryder Hutchinson et al.
Mammalian reoviruses are promising oncolytic agents, but most preclinical and clinical work has focused on the type 3 Dearing (T3D) prototype, potentially underestimating the therapeutic relevance of broader reovirus genetic diversity. Beca...
Syncytia Formation in the Pathogenesis of SARS-CoV-2 Infection: Lessons from Viral Infections [0.03%]
SARS-CoV-2感染的发病机制中的合胞体形成：病毒性感染的经验教训
Aida Tafazoli,Razieh Dowran
Aida Tafazoli
It is widely known that numerous enveloped viruses can produce multinucleated cells (syncytia) as a result of viral entry-related membrane fusion events. By protecting the virus from the host's immune reaction, these syncytia are thought to...
Screening and Characterization of Nanobody Against the Emerging Dairy Cattle H5N1 Influenza Virus [0.03%]
针对新型牛源H5N1流感病毒筛选及单域抗体的初步鉴定
Fang Li,Jingjing Chen,Jiangrun Zhu et al.
Fang Li et al.
Background:The ongoing spillover of highly pathogenic avian influenza H5N1 virus into mammalian species, including recent outbreaks in dairy cattle, underscores an urgent need for broadly effective therapeutics. Nanobody, the variable domai...
Immunoinformatics-Driven Design of a Multiepitope Vaccine for Rustrela Virus-Induced Neurological Diseases: A New Frontier in Encephalitis and Meningoencephalitis Prevention [0.03%]
基于免疫信息学设计锈草莓病毒诱导的神经疾病多表位疫苗：预防脑炎和脑膜脑炎的新前沿
Saeeda Tariq,Saad Bhutta,Muhammad Awais et al.
Saeeda Tariq et al.
Rustrela virus (Rubivirus strelense) is a single-stranded, non-segmented RNA virus that causes brain diseases in animals, especially encephalitis and meningoencephalitis. Its rapidly mutating RNA genome complicates control, making a vaccine...
Single-Cell Transcriptomic Profiling Reveals Molecular Alterations in the Airway Epithelial Cells of Children with Wheezing Infected by Respiratory Syncytial Virus [0.03%]
单细胞转录组分析揭示呼吸道合胞病毒所致喘息患儿气道上皮细胞分子改变
Zhengbo Wei,Lifang Wang,XingHai Ding et al.
Zhengbo Wei et al.
This study aimed to explore the molecular alterations in airway epithelial cells in children with wheezing infected by respiratory syncytial virus (WheezeRSV). This study extracted the single-cell sequencing data of two control and wheezeRS...
Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials [0.03%]
氨茶碱对COVID-19炎症标志物影响的 meta 分析
Danyal Imani,Navid Dashti,Amir Peymani et al.
Danyal Imani et al.
The hyperinflammatory response in COVID-19 is a major factor contributing to morbidity. Pentoxifylline, a methylxanthine derivative, has immunomodulatory properties, but its effects on inflammatory markers in COVID-19 remain unclear. This m...
A Robust Defense Against IPNV and VHSV by Designing Revolutionary Multi-Epitope Vaccine Utilizing Immunoinformatics Approaches [0.03%]
利用免疫信息学方法设计革命性多表位疫苗以抵御稳定且强力的传染性胰腺坏死病病毒和病毒性出血败血症病毒感染
Elham Mohammed Khatrawi,Syed Yasir Ali,Syed Luqman Ali et al.
Elham Mohammed Khatrawi et al.
In the intricate world of aquatic ecosystems, infectious pancreatic necrosis virus (IPNV) and viral hemorrhagic septicemia virus (VHSV) emerge as formidable threats to marine life, posing diverse diseases that reverberate through shared hos...