Building a resilient ovarian reserve: Early soma-oocyte interactions [0.03%]
构建有弹性的卵巢储备：早期机体-卵细胞相互作用
Cora Thompson,Alaina Houghton-Chamberlain,Joan S Jorgensen
Cora Thompson
Soma-oocyte interactions are a key component in female fertility. First the ovary must adopt a female fate and become populated with supporting somatic cells. We discuss the origins of each somatic cell type with a particular focus on pre-g...
Satoko Matsuyama,Sudhanshu Bhushan,Tony DeFalco
Satoko Matsuyama
The testis is a unique organ that simultaneously supports spermatogenesis and steroidogenesis, and it must maintain host defense against infection while suppressing excessive immune responses in an environment that includes germ cell antige...
Emma A Gilbert,Christopher B Geyer
Emma A Gilbert
To produce haploid gametes, mitotic germ cells in both sexes must transition to the specialized meiotic program. The molecular details underlying this transition - termed meiotic initiation - are poorly defined in higher eukaryotes, especia...
Impact of cancer immunotherapies on oocyte health and ovarian function [0.03%]
癌症免疫治疗对卵母细胞健康和卵巢功能的影响
Yasmin Lewis,Yujie Cao,Jordan Higgins et al.
Yasmin Lewis et al.
The ovary is an immunologically active organ in which tightly regulated interactions between immune cells, cytokines, and reproductive hormones are essential for follicle and oocyte development, ovulation, luteal function, and maintenance o...
The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan [0.03%]
卵巢间质作为调控生殖周期卵泡发育和卵子质量的关键因素
Shweta S Dipali,Francesca E Duncan
Shweta S Dipali
The follicle is the functional unit of the ovary and has been the historical focus of ovarian biology research. However, recently a greater emphasis has been placed on the role of the ovarian microenvironment, or stroma, in supporting the f...
Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles [0.03%]
细胞间环核苷酸动力学介导哺乳动物预排卵卵泡中卵母细胞的减数分裂
Jeremy R Egbert
Jeremy R Egbert
The cell cycle of the mammalian oocyte arrests in prophase around the time of birth and remains in meiotic arrest as it grows interdependently with increasing layers of surrounding somatic cells as a structure called an ovarian follicle. Wi...
Claude Robert,Ricardo Perecin Nociti
Claude Robert
Communication between cells is essential for orchestrating tissue, organ, and whole-body cohesion. The communication can occur within the same cell (autocrine signaling), between neighboring cells (paracrine signaling), from distant cells (...
In-Won Lee,Deepak Adhikari
In-Won Lee
Primordial follicle activation represents the pivotal and rate-limiting transition that governs the size and longevity of the ovarian reserve, thereby shaping female reproductive lifespan. Although the vast majority of primordial follicles ...
The "Community Effect" of spermatogonial stem cells (SSCs) and their descendants on the induction of the SSC niche: Perspectives and hypotheses [0.03%]
雄性生殖干细胞及其子代的“社区效应”与诱导生境形成：观点和假设
Makoto Nagano
Makoto Nagano
Since the first description of "stem cells" in spermatogenesis in 1885, our understanding of spermatogonial stem cells (SSCs) has evolved over time. Normal function of SSCs is critical for the survival of a species, and thus, a balanced con...
Huayu Qi
Huayu Qi