Identification of ADH1C and MZB1 as Potential Ultrasound-Modulated Biomarkers for Diagnosis, Prognosis, and Immune Microenvironment Profiling in Ovarian Cancer [0.03%]
ADH1C和MZB1作为卵巢癌诊断、预后及免疫微环境谱分析的潜在超声调制生物标志物识别
Juanpeng Yu,Shengsheng Yu
Juanpeng Yu
Background: Although alcohol dehydrogenase 1 C (ADH1C) and marginal zone B and B1 cell-specific protein (MZB1) have shown promise as biomarkers for various cancers, little is known about their clinical importance in ovari...
Ultrasound-Enhanced Delivery of the Quercetin Derivative ANL3 Activates the FOXO1A- NDRG2- SOD2 Axis to Induce Endoplasmic Reticulum Stress in Osteosarcoma [0.03%]
高强度聚焦超声联合ANL3衍生物通过FOXO1A-NDRG2-SOD2轴引起内质网应激抑制成骨细胞恶性转化及侵袭能力研究
Jun Qian,Wangsheng Wu,Haoyu Wang et al.
Jun Qian et al.
Background: Quercetin, a naturally occurring flavonoid with recognized antitumor properties, has limited therapeutic applicability due to its low water solubility and bioavailability. To address these issues, a new querce...
Sonodynamic Therapy: Porphyrin-Based Sensitizers and Low-Intensity Ultrasound for Precision Treatment of Glioblastoma [0.03%]
声动力疗法：卟啉类敏化剂与低强度超声用于胶质母细胞瘤的精准治疗
Huda M Alshanbari,Mohammed Abaker,Yazeed Alashban et al.
Huda M Alshanbari et al.
Sonodynamic treatment (SDT) is also beginning to be of interest as an effective noninvasive approach to treat glioblastoma multiforme, in which ultrasonically triggered sensitizers generate an effector of cytotoxic reactive oxygen species (...
Zhongsen Dou,Zhiwei Wang,Fanglai Zhu
Zhongsen Dou
Background: Cyclooxygenase-2 (COX-2) serves as a pivotal molecule bridging inflammation and tumor development, playing a central role in the initiation, progression, and malignant transformation of colorectal adenomas. ...
Functionalized Graphene Oxide Nanostructures Enhance Targeted Drug and Gene Delivery, Immunomodulation, Photothermal/Photodynamic Therapy, and Cancer Theranostics [0.03%]
功能化石墨烯氧化物纳米结构增强靶向药物和基因传递，免疫调节，光热/光动力疗法以及癌症诊疗一体化
Nikita Udaipuria,Sankha Bhattacharya,Tanvi Maheshwari et al.
Nikita Udaipuria et al.
Background: Graphene oxide (GO), a multifunctional two-dimensional nanomaterial, has gained significant attention in oncology due to its large surface area, tunable surface chemistry, and excellent biocompatibility. These properties enable ...
Advances in Gastric Cancer Management: Signaling Pathways, Emerging Diagnostic and Therapeutic Strategies [0.03%]
胃癌诊疗新进展：信号转导、新兴诊断和治疗策略
Rutvi Agrawal,Priyanka Jurel,Akash Garg et al.
Rutvi Agrawal et al.
Background: Gastric cancer (GC) is among the most common malignancies worldwide and represents a major cause of cancer-related mortality. The incidence of GC varies significantly across regions due to genetic predisposition, environmental e...
Epigenetic Suppression of Histone Deacetylase 4 Boosts T Cell Homing via CXCR3 in Lung Cancer: A Step Toward Ultrasound-Guided Immunotherapy [0.03%]
表观遗传抑制组蛋白去乙酰化酶4促进肺癌T细胞CXCR3介导的归巢：向超声引导免疫治疗迈进的重要一步
Lingqiong Lan,Yi Wang,Liming Guo et al.
Lingqiong Lan et al.
Background: Lung cancer is the biggest reason of cancer-correlated death worldwide, owing primarily to immune evasion and poor response to current immunotherapies. Objective: The aim of this work was focused on the immunomodulatory effect o...
An Integrated Analysis of Four Targeted Thorium Conjugates to Assess the 227Th and 223Ra Distribution and Tissue-Related Radiation [0.03%]
227 Thur 223 Ra分布及与组织相关的辐射的四靶钍连接物的综合分析
Michael Block,Adriaan Cleton,Carsten Zieschang et al.
Michael Block et al.
Introduction: α-emitting radiopharmaceuticals are increasingly being evaluated as potential cancer therapeutics. In this study, the authors evaluated the distribution of thorium-227 (227Th) and its first daughter nuclide, radium-223 (223Ra...
Postphenomenology, Phronesis, and the Physician: Cancer Care in Radiogenomic Artificial Intelligence Theranostics [0.03%]
后现象学、实践智慧与医师：放射基因组人工智能诊疗中的癌症治疗护理研究
J Harvey Turner
J Harvey Turner
Postphenomenology examines the cultural dimension of human-technology relations whereby innovations, such as artificial intelligence (AI), re/shape our behavior and relation to reality. Generative AI is amoral and uncaring, but it is mediat...
The Schrödinger's Cat Paradox: Can MAMMI PET with 68Ga-FAPI Determine Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Omitting Surgery? [0.03%]
薛定谔的猫悖论：MAMMI PET与68Ga-FAPI能否确定新辅助化疗后乳腺癌达到病理完全缓解从而省略手术？
Melis Oflas,Duygu Has Simsek,Ravza Yilmaz et al.
Melis Oflas et al.
Aim: This study aims to evaluate the utility of 68Ga-FAPI PET/CT in combination with MAMMI PET for assessing pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) in patients with breast cancer. Materials and Methods: This...