Lactylation Signatures as Predictors of Prognosis and Therapeutic Response in Lung Adenocarcinoma: Implications for Ultrasound-Based Therapeutic Strategies [0.03%]
乳酰化标志物作为肺癌预后和治疗反应预测因素的理论及超声引导下的治疗策略
Qingchun Cai,Chenglu Huang,Yu Huang et al.
Qingchun Cai et al.
Background: Lactylation, a unique post-translational alteration, has been identified as an important epigenetic regulator of cancer metabolism, immune evasion, and treatment resistance. Recent research reveals that ultras...
PWidFHNet: Parallel Wider Forward Harmonic Net to Classify Breast Cancer Using Histopathological Images [0.03%]
用于使用组织病理学图像分类乳腺癌的并行更宽的前向谐波网(PWidFHNet)
Rajesh Prasad,Jayashree Prasad,Nihar Ranjan et al.
Rajesh Prasad et al.
Background/purpose: Breast cancer poses a significant health risk to women worldwide. The timely diagnosis of breast cancer is essential to increase the survival rate and to control premature mortality. However, existing ...
Prognostic Factor Analysis and Nomogram Development in Castration-Resistant Prostate Cancer with Visceral Metastases for Future Radionuclide Therapy Selection [0.03%]
前列腺癌去势抵抗性 visceral metastases 患者预后因素分析及分子影像指导未来核素治疗的列线图模型建立
Pengfei Xu,Xianfu Lin,Yunhai Zhu et al.
Pengfei Xu et al.
Objective: To identify independent prognostic factors in castration-resistant prostate cancer (CRPC) patients with visceral metastases, construct and internally validate a prognostic nomogram for individualized risk strat...
Development of a 177Lu-Labeled Glypican-3-Targeted Antibody Radiopharmaceutical for Adjuvant Radionuclide Therapy Following Hepatocellular Carcinoma Resection [0.03%]
一种针对肝细胞癌术后辅助放射性核素治疗的糖皮质激素受体3靶向抗体放射药开发：177Lu标记
Ke Fang
Ke Fang
Background: Hepatocellular carcinoma (HCC) remains the major cause of cancer-related mortality worldwide due to high postoperative recurrence rates and limited treatment options for minimal residual disease (MRD).Methods: In this study, gly...
Synergistic Mechanisms and Clinical Progress of Radionuclide Therapy Combined with Immune Checkpoint Inhibitors in Colorectal Cancer [0.03%]
放射性核素治疗联合免疫检查点抑制剂在结直肠癌中的协同机制及临床进展
Qi Fan,Zhengwei Fu,Ming Xu et al.
Qi Fan et al.
Background: Radionuclide therapy (RNT) and immune checkpoint inhibitors (ICIs) show mechanistic synergy in colorectal cancer (CRC), but clinical evidence remains limited.Objective: To summarize biological rationale, translational mechanisms...
Personalized Radionuclide Therapy via Avidin-Biotin Pretargeting: Biodistribution and Dosimetry of 177Lu-DOTA-biotin with AvidinOX™ in Solid Tumors [0.03%]
通过卵白素-生物素预靶向的个性化核素治疗：177Lu-DOTA-生物素与AvidinOX在实体瘤中的药代动力学和剂量学研究
Freddy Gonzalez,Vivek Subbiah,S Cheenu Kappadath et al.
Freddy Gonzalez et al.
Purpose: AvidinOX™ forms a long-lasting artificial receptor that supports effective in vivo binding of circulating biotinylated therapeutic 177Lu-DOTA-biotin. We investigated the biodistribution and radiation dosimetry o...
Neural Decoding of Ultrasound-Modulated Pain States via Deep Learning: Insights from Functional Magnetic Resonance Imaging Data [0.03%]
基于深度学习的超声波调制痛觉状态的功能磁共振脑信号神经解码研究
Dawood Khan,Hafiz Zia Ur Rehman,Sara Ali et al.
Dawood Khan et al.
Focused ultrasound (FUS) is a noninvasive neuromodulation technique capable of modulating deep-brain circuits with millimeter precision. When combined with functional magnetic resonance imaging (fMRI), it enables causal decoding of brain-st...
Review of Glypican-3-Targeted Imaging Agents for Hepatocellular Carcinoma [0.03%]
甘皮素-3导向肝细胞癌影像试剂的评述
Wenye Li,Liqin Liu
Wenye Li
Background: Hepatocellular carcinoma (HCC) is a highly prevalent malignant tumor globally, with low survival rates in advanced stages. Therefore, early diagnosis and precision therapy are pivotal to improving patient prog...
Clinical Laboratory Evaluation of the Biodistribution of a Radiolabeled Antimicrobial Peptide for Precision Radiopharmaceutical-Guided Radionuclide Therapy in Severe Pneumonia Among Immunocompromised Patients with Cancer [0.03%]
免疫功能低下的癌症患者的放射性药物引导放射性核素治疗的生物分布的临床试验评估：重症肺炎中放射标记抗菌肽的临床实验室评价
Xiaojuan Niu,Xiaoting Yang,Jianhua Jiao
Xiaojuan Niu
Background: Pneumonia in immunocompromised patients with cancer is associated with high morbidity, diagnostic uncertainty, and poor short-term outcomes. Precision radiopharmaceutical approaches may improve lesion localiza...
Single-Cell Transcriptomics in Triple-Negative Breast Cancer: Implications for Radionuclide Therapy in Precision Oncology [0.03%]
三阴性乳腺癌单细胞转录组学在精准肿瘤学放射核素治疗中的应用意义
Xiaoxiao Xing,Huihuan Yu,Songliang Zhang
Xiaoxiao Xing
Background: Triple-negative breast cancer (TNBC) remains one of the most clinically challenging malignancies, characterized by aggressive behavior, high metastatic propensity, and limited therapeutic options. Conventional...