Characterization of Adverse Drug Effects to Three Radiopharmaceuticals: A Descriptive Analysis from WHO-VigiAccess [0.03%]
基于WHO-VigiAccess数据库的三种放射性药物不良反应特征描述性分析研究
Yiheng Jin,Kunlun Gui,Kaixin Chen et al.
Yiheng Jin et al.
Background: Radiopharmaceuticals are being used more frequently to treat neuroendocrine tumors and advanced prostate cancer; however, their clinical application is associated with adverse drug reactions (ADRs) that may af...
Cavitation-Free Acoustic Sensitization Enhances PLK4-Targeted Therapy Using the Phillyrin Derivative DE02 in Osteosarcoma [0.03%]
无空化声敏化通过PLK4靶向增强菲领取导化合物DE02治疗骨肉瘤的效果
Jin Yang,Haoyu Wang,Zongyun He et al.
Jin Yang et al.
Objective: To ascertain whether cavitation-free acoustic sensitization enhances intracellular delivery and amplifies polo-like kinase 4 (PLK4)-targeted signaling to boost the phillyrin derivative DE02's antitumor efficacy...
Expanding the Therapeutic Window in Oncology: Modern Strategies and Future Directions [0.03%]
扩大肿瘤学治疗窗口的现代策略及未来方向
Shital Dange,Mohammed Musharraf Ali,Mamatha Gavisiddaiah et al.
Shital Dange et al.
Background:The enhancement of the therapeutic window (TW) in oncology remains a significant challenge, as the majority of anticancer treatments face difficulties in achieving optimal tumor control while minimizing adverse effects. Tradition...
Precision Oncology with 177Lu-PSMA-617 Radionuclide Therapy in Elderly Patients with Metastatic Castration-Resistant Prostate Cancer [0.03%]
镥-177-PSMA-617核素治疗在老年转移性去势抵抗性前列腺癌患者中的精准治疗效果
Fayou Zhou,Yongqing Zheng,Liang Huang et al.
Fayou Zhou et al.
Objective: To investigate the treatment response status in elderly patients with metastatic castration-resistant prostate cancer (mCRPC) receiving 177Lu-PSMA-617 radioligand therapy within a precision oncology framework, ...
Radiopharmaceutical-Guided Personalized Adjuvant Radiotherapy Planning after Esophageal Cancer Resection [0.03%]
用于食管癌术后个性化辅助放疗的放射药物引导放疗规划
Zhida Fu,Yinghui Fang,Dapeng Wang et al.
Zhida Fu et al.
Background: Esophageal cancer often has a significant locoregional recurrence risk after curative resection. Conventional postoperative radiation is largely based on anatomical imaging, which may not adequately detect mic...
Radiopharmaceutical Oncology Care Supported by Ultrasound-Guided Superior Vena Cava-Right Atrial Junction Port Tip Positioning in Adult Cancer Patients [0.03%]
超声引导下上腔静脉-右心房连接处输注港定位技术在成人肿瘤患者放射性药物治疗中的应用研究
Quan Ling,Yinqi Yang,Junlin Wen et al.
Quan Ling et al.
Background: In this single-center retrospective study, the authors evaluated whether real-time ultrasound-guided positioning of an implantable venous access port catheter tip at the superior vena cava-right atrial junction (SVC-RAJ) reduces...
CavitoMod-UTMDNet: A Mechanistic Cavitation-Diffusion Framework for Ultrasound-Targeted Microbubble Destruction-Enhanced Liposomal Doxorubicin Delivery in Pancreatic Cancer [0.03%]
一种用于胰腺癌的超声微泡靶向破坏增强脂质阿霉素递送的机理型空化-扩散框架(CavitoMod-UTMDNet)
Yazeed Alashban,Ghada Moh Samir Elhessewi,Mohammed Maray et al.
Yazeed Alashban et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest treatment responses since it contains desmoplastic stroma, lacks good vascularity, and has high interstitial fluid pressures, which are the most damaging factors dep...
Clinical Evaluation of Ultrasound-Enhanced Radiotracer Uptake for Radioligand Therapy in Metastatic Prostate Cancer [0.03%]
声学造影增强放射性配体治疗摄取量的临床评估——前列腺癌骨转移患者中的应用研究
Yangbing Liang,Qingguo Wu,Yiwen Liang et al.
Yangbing Liang et al.
Background: Low-intensity pulsed ultrasound (LIPUS) may noninvasively enhance intratumoral delivery of radiopharmaceuticals, but clinical data are scarce. The authors prospectively evaluated whether adding LIPUS to prosta...
Ultrasound-Assisted Radiopharmaceutical Investigation of GNL1-Mediated AKT-P53-P21 Axis Activation in Cervical Cancer Progression [0.03%]
声学造影介导的GNL1激活Akt-p53-p21信号轴促进宫颈癌发展的放射药剂学研究
Yingying Jiang,Jing Ren,Junzhen Tao
Yingying Jiang
Background: Cervical cancer is a leading cause of cancer death in women worldwide, and the outcomes for advanced or recurrent disease remain poor. Ultrasound-assisted delivery could increase intratumoral uptake of radioph...
Prospective Clinical Assessment of Ultrasound-Assisted Radiopharmaceutical Imaging Under Anesthesia for Oncologic Evaluation [0.03%]
麻醉超声引导放射性药物显像在肿瘤评估中的临床应用研究
Qinghua Meng,Li Lin,Rongzhu Lei
Qinghua Meng
Background: Ultrasound (US) is widely used in oncology, yet prospective clinical evidence for integrating US into radiopharmaceutical positron emission tomography/computed tomography (PET/CT) workflows remains limited. We...