Curved Vertebroplasty System Combined with Targeted Radionuclide Therapy for Tumor-Related Pathological Vertebral Fractures [0.03%]
结合放射性核素靶向治疗的曲面椎体成形系统治疗肿瘤骨转移所致病理性骨折
Haitao Zhou,Lili Sheng,Zhengxin Zhou
Haitao Zhou
Objective: To compare the clinical efficacy of the curved vertebroplasty system combined with targeted radionuclide therapy (radium-223/strontium-89) versus conventional percutaneous vertebroplasty (PVP) combined with rad...
Development of a Freeze-Dried Bevacizumab Kit for 99mTc Radiolabeling and Preclinical Evaluation In Vitro and in Normal Mice [0.03%]
一种用于~(99)MTc标记的贝伐单抗冻干包及其体外和正常小鼠体内药代动力学预试验研究
Thi Khanh Giang Nguyen,Thi Ngoc Nguyen,Thanh Binh Nguyen et al.
Thi Khanh Giang Nguyen et al.
Background: Bevacizumab, a humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), was lyophilized and radiolabeled with 99mTc for tumor-targeted imaging. In this study, a freeze-dried kit was d...
Radionuclide-Based Theranostic Mapping for Spatially Optimized Treatment Planning in Cervical Carcinoma [0.03%]
基于放射性核素的宫颈癌空间优化治疗计划的诊疗一体化显像地图法研究
Limiao Li,Lin Feng,Yue Zhou et al.
Limiao Li et al.
Background: Intratumoral heterogeneity in cervical carcinoma may influence absorbed dose distribution, treatment resistance, and response, but is not adequately captured by conventional uniform planning. ...
MICA/MICB-Mediated NKG2D Immune Escape in Cervical Cancer: Single-Cell Transcriptomic Mapping of Radionuclide Therapy Targets for Precision Radioimmunotherapy [0.03%]
宫颈癌中MICA/MICB介导的NKG2D免疫逃逸：单细胞转录组绘制放射性核素治疗靶点以实现精确放射免疫治疗
Jinchuan Ci,Chen Wang,Yuli Wang et al.
Jinchuan Ci et al.
Background: Cervical cancer harbors a profoundly immunosuppressive tumor microenvironment (TME) that impairs innate and adaptive antitumor immunity and, critically, limits the efficacy of emerging radioimmunotherapy strat...
Radionuclide Therapy Integrated Multimodal Transsylvian Microneurosurgical Management of Type 5 Insular and Paralimbic Gliomas for Precision Oncology [0.03%]
精确放射性药物治疗综合多模式经侧脑室微创神经外科手术管理5型岛叶和边缘叶胶质瘤的精准肿瘤学疗法
Jinshan Wang,Jian Wang,Ao Zhu et al.
Jinshan Wang et al.
Background: Type 5 insular and paralimbic gliomas are surgically challenging because resection is limited by perforator-rich vascular anatomy and eloquent subcortical pathways, often leaving clinically relevant residual d...
Validation of Manual In-House Synthesis, Imaging, Biodistribution, and Dosimetry of Tb-161 PSMA-617 for mCRPC Patients in a Tertiary Health Care Center: A Proof-of-Concept Study [0.03%]
在三级医疗中心手动合成、成像、生物分布和剂量测定Tb-161 PSMA-617用于mCRPC患者的验证：一项概念验证研究
Parul Thakral,Nishant Rana,Abhishek Uppal et al.
Parul Thakral et al.
Background: Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge, particularly in patients with suboptimal response to 177Lu PSMA-617. Terbium-161 (Tb-161), with its emission of β-parti...
Precision Locoregional Therapy Combined with Immune Checkpoint Blockade for Intermediate-Advanced Hepatocellular Carcinoma [0.03%]
精准局部治疗联合免疫检查点抑制剂治疗中晚期肝细胞癌
Xiaoyu Liu,Sheng Zheng,Juan Yang et al.
Xiaoyu Liu et al.
Background: The potential value of combining transarterial chemoembolization (TACE) with immune checkpoint inhibitors (ICIs) for hepatocellular carcinoma (HCC) at intermediate-to-advanced stages remains incompletely defin...
Effects of Perioperative 177Lutetium-Labeled Targeted Radionuclide Therapy on Inflammatory Response and Intestinal Recovery in Colorectal Cancer [0.03%]
perioperative 177Lu标记靶向放射性核素治疗对结直肠癌炎性反应及肠道恢复的影响
Jianhua Sun,Yong Zhang,Sai Zhang
Jianhua Sun
Objective: To investigate the effects of perioperative 177Lutetium (177Lu)-labeled anticarcinoembryonic antigen (CEA)-targeted radionuclide therapy (TRT) on perioperative inflammatory response, intestinal function recover...
Hemoglobin-Based Oxygen Carriers Promoted the Antitumor Effect of 177Lu-PSMA-617 by Enhancing DNA Repair Capacity of Immune Cells [0.03%]
基于血红蛋白的氧载体通过增强免疫细胞DNA修复能力促进177Lu-PSMA-617抗肿瘤作用
Danyue Qu,Chenyi Shao,Xinyuan Ji et al.
Danyue Qu et al.
Purpose: Targeted radionuclide therapy with 177Lu-PSMA-617 prolongs radiographical progression-free survival in prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC), yet 13% of patients ...
Martin W Brechbiel,Alan G Harris,Craig H Sherman
Martin W Brechbiel