Real-Time Super-Resolution Ultrasound Imaging for Monitoring Tumor Response During Intensive Care Management of Oncologic Emergencies [0.03%]
用于肿瘤紧急情况强化护理的实时超声波超分辨率成像监测肿瘤反应
Jinping Wu,Wentao Xu,Li Li et al.
Jinping Wu et al.
Background: Oncologic emergencies in critically ill cancer patients frequently require rapid, real-time assessment of tumor responses to therapeutic interventions. However, conventional imaging modalities such as computed tomography and mag...
Proteogenomic Biomarker Profiling for Predicting Radiolabeled Immunotherapy Response in Resistant Prostate Cancer [0.03%]
用于预测放射性标记免疫疗法对耐药前列腺癌反应的蛋白质基因组生物标志物谱分析
Benchun Yan,Yuqiu Gao,Yulong Zou et al.
Benchun Yan et al.
Treatment resistance prevents patients with preoperative chemoradiotherapy or targeted radiolabeled immunotherapy from achieving a good result, which remains a major challenge in the prostate cancer (PCa) area. A novel integrative framework...
Investigation on the Inhibitory Mechanism of Chai Hu Hua Ji Tang on Liver Cancer Based on a Network Pharmacology Analysis [0.03%]
基于网络药理学分析的柴胡化戟汤抑肝癌机制研究
Hua Xu,Yi Huang,Feng Li et al.
Hua Xu et al.
Context: Hepatocellular carcinoma (HCC) poses a serious threat to human health due to its high incidence and mortality rates. In recent years, the application of traditional Chinese medicine (TCM) in the comprehensive treatment of liver can...
Exploring Targeted Delivery Systems for Boron Neutron Capture Therapy and Its Potential as a Promising Therapeutic Modality for Hepatocellular Carcinoma [0.03%]
用于硼中子俘获治疗的靶向递送系统的研究及其作为治疗肝细胞癌的一种有前景的治疗模式的潜力研究
Tanglong Zhang,Pengcheng Zhang,Huanyu Zhang et al.
Tanglong Zhang et al.
Background: Boron neutron capture therapy (BNCT) is a precision binary radiotherapy. In this modality, thermal neutrons combine with 10B to induce a nuclear reaction that kills tumor cells. Its therapeutic efficacy depends on the targeted a...
Artificial Intelligence-Driven Ultrasound Identifies Rare Triphasic Colon Cancer and Unlocks Candidate Genomic Mechanisms via Ultrasound Genomic Techniques [0.03%]
人工智能驱动的超声波识别罕见三相结肠癌并通过超声基因组技术解锁候选基因机制
Xianqiao Li,Shukai Wang,Ulf Dietrich Kahlert et al.
Xianqiao Li et al.
Background: Colon cancer is a heterogeneous disease, and rare subtypes like triphasic colon cancer are difficult to detect with standard methods. Artificial intelligence (AI)-driven ultrasound combined with genomic analysis offers a promisi...
Targeting FOXE1-Mediated LAMC2 Expression to Improve Preoperative Chemoradiotherapy Outcomes in Lung Cancer Patients at Risk of Brain Metastasis [0.03%]
靶向作用于FOXE1介导的LAMC2表达以改善肺癌患者术前放化疗预后以降低脑转移风险
Yiping Zheng,Yinghui Huang,Jianfeng Cai et al.
Yiping Zheng et al.
Objective: This study elucidated the role of the forkhead box E1 (FOXE1)-laminin γ2 (LAMC2) signaling axis in promoting brain metastasis (BM) of lung cancer and evaluate its potential as a therapeutic target to enhance the efficacy of preo...
Targeting the MCM10/p53/p21/CCND1 Axis in Colorectal Cancer: Evaluating the Therapeutic Potential of Ultrasound [0.03%]
靶向结直肠癌的MCM10/p53/p21/CCND1轴：评估超声治疗潜力
Hao Wu,Changyu Wen,Zheng Jiang
Hao Wu
Background: Colorectal cancer (CRC), the second leading cause of cancer-related deaths globally, continues to lack effective early diagnostic biomarkers and therapeutic strategies. Minichromosome maintenance protein 10 (MCM10), a replicatio...
Radiosynthesis and In Vitro Bioevaluation of 99mTc-Temozolomide as a Radiotracer for Glioma Imaging [0.03%]
放射合成和体外生物评价99mTc-Temosozole作为胶质瘤成像的示踪剂
Sachin Tayal,Satvika Sharma,Jasmine Sati et al.
Sachin Tayal et al.
Background: Temozolomide (TMZ), an alkylating drug used for the treatment of gliomas, has to date not been exploited for its potential role as a radionuclide-imaging probe. Therefore, the present study radiosynthesizes [99mTc]Tc-TMZ and eva...
Advances in STING Pathway Modulation for Cancer and Immunotherapy: A Comprehensive Review of Preclinical and Clinical Studies (2020-2024) [0.03%]
STING通路调节在癌症和免疫治疗中的进展：对临床前研究和临床研究（2020-2024）的全面回顾
Rahaman Shaik,Komal Suthar,Chandrika Balija et al.
Rahaman Shaik et al.
In cancer immunotherapy, the stimulator of interferon genes (STING) pathway regulation has become a promising new approach, offering potential solutions to overcome limitations of current treatments. Recent advances have revealed intricate ...
Oxidative Stress Links Thyroid Autoimmunity to Cancer: Peroxiredoxin 2 Protection via Genomic and Single-Cell Insights [0.03%]
氧化应激将甲状腺自身免疫与癌症联系起来：通过基因组和单细胞洞察力保护过氧化氢酶2
Jie Kang,Shengcai Wang,Xin Ni
Jie Kang
Objective: This study identifies shared genetic factors linking Hashimoto's thyroiditis (HT) and thyroid cancer (TC) using an integrated multiomics approach. Methods: We combined Mendelian randomization (MR) analysis using FinnGen genome-wi...