Jiachuang Zheng,Hui Luo,Zhixia Zheng et al.
Jiachuang Zheng et al.
Sarcopenia attenuates independence and mobility in older adults, and scalable nonpharmacological interventions are needed. This trial evaluated whether a 12-week exercise program improves activities of daily living, muscle mass and strength...
Elucidating the Mechanism of Action of the Astragalus-Ginseng Herb Pair in Treating Coronary Heart Disease: A Network Pharmacology and Experimental Validation Approach [0.03%]
基于网络药理学和实验验证的黄芪参配伍治疗冠心病作用机制研究
Zhiping Liu,Jia Chen,Tianwei Meng et al.
Zhiping Liu et al.
To elucidate the mechanism of action of the Astragalus membranaceus-Panax ginseng herb pair in treating coronary heart disease (CHD) through network pharmacology combined with molecular docking and experimental validation. Active ingredient...
Pharmacodynamic Effects of Salvia miltiorrhiza- Dalbergia Odorifera in the Treatment of Ischemic Stroke Based on the Mixture Design [0.03%]
基于混杂设计的丹参降香药对治疗缺血性卒中的药效学作用研究
Ziheng Ding,Chengzhao Liu,Kedi Liu et al.
Ziheng Ding et al.
Salvia miltiorrhiza(SM)-Dalbergia odorifera (DO) is a commonly used circulating blood and transforming stasis drug pair for the treatment of cardiovascular and cerebrovascular diseases, but systematic studies on the optimal ratio for the tr...
The Role of the Glymphatic System in Alzheimer's Disease: Mechanisms, Evidence, and Therapeutic Implications [0.03%]
甘淋巴系统在阿尔茨海默病中的作用：机制、证据和治疗意义
Yaran Li,Juan Li,Xinhong Liu et al.
Yaran Li et al.
Alzheimer's disease (AD) is an aging-associated neurodegenerative disorder characterized by amyloid-β (Aβ) and tau accumulation and progressive cognitive decline. Increasing evidence implicates the glymphatic system, a brain-wide perivasc...
Agrin as a Stable Biomarker for Muscle Strength Decline in Elderly Sarcopenic Patients Associated with Neuromuscular Junction Dysfunction [0.03%]
肌萎缩作为神经肌肉接头功能障碍的老年人 sarcopenic 患者肌力下降的稳定生物标志物
Jihai Chen,Nuo Cheng,Ye Liu et al.
Jihai Chen et al.
Agrin-mediated neuromuscular junction (NMJ) morphological alterations is one of the main pathogeneses of sarcopenia. The aim of this study was to observe the changes in serum agrin in patients with different degrees of sarcopenia and the al...
Polysaccharide-Rich Herbal Formula Attenuates Skin Aging and Oxidative Stress in VCD-Induced Menopause Models via Regulation of AQP-3, C1QBP, and K19 [0.03%]
多糖类中药配方通过调节AQP-3，C1QBP和K19来缓解VCD诱导的绝经模型的皮肤衰老和氧化应激
Yingqi Yu,Ruxi Gao,Guoshun Shan et al.
Yingqi Yu et al.
To investigate the protective effects of Nvshi Oral Liquid on skin aging and oxidative stress in 4-vinylcyclohexene diepoxide (VCD)-induced menopausal rats and Ultraviolet B (UVB)-irradiated HaCaT cells. VCD-induced menopausal rats and UVB-...
Effect of Obstructive Sleep Apnea and CPAP on Telomere Length and Its Associated Mechanisms: A Pilot Study [0.03%]
阻塞性睡眠呼吸暂停及持续气道正压通气对端粒长度的影响及其相关机制的探索性研究
Priscila Farias Tempaku,Vânia D&#x;Almeida,Sylvia Maria Affonso da Silva et al.
Priscila Farias Tempaku et al.
The present study aimed to investigate the effect of obstructive sleep apnea (OSA) and its treatment with continuous positive airway pressure (CPAP), the gold standard treatment for OSA on changes of telomere length and its associated mecha...
Betulinic Acid Attenuates Vascular Smooth Muscle Cell Senescence and Aortic Vascular Aging via PPAR-α/CPT1A-Mediated Fatty Acid Oxidation [0.03%]
桦皮酸通过PPAR-α/CPT1A介导的脂肪酸氧化抑制血管平滑肌细胞衰老和主动脉血管衰老
Tingting Lu,Linghuan Wang,Sijia Chen et al.
Tingting Lu et al.
Vascular stiffness and aging are critical contributors to cardiovascular diseases. Whether betulinic acid (BA), a natural triterpenoid, alleviates vascular aging remains unclear. Mouse aortic smooth muscle cells (MASMCs) with oleic acid (OA...
Huntington's Disease: An Overview of Biomarkers in Prognostic, Diagnostic, and Therapeutic Management [0.03%]
亨廷顿舞蹈病的生物标志物概述：预后、诊断和治疗管理中的生物标志物
Geetanjali Singh,Charan Singh,Arti Singh
Geetanjali Singh
Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric disturbances. It is caused by the abnormal expansion of cytosine-adenine-guanine triplet repeats in...