Human Embryoid Body-Based Assays for Preclinical Screening of Potential Teratogenic Drugs: Antiviral Drugs for Hepatitis B Virus as Examples [0.03%]
基于人胚胎体的潜在致畸药物临床前筛查试验：以乙型肝炎抗病毒药为例
Renjun Yang,Nuoya Yin,Yang Zhang et al.
Renjun Yang et al.
Ensuring the safety of drugs during pregnancy is a critical concern in clinical practice. Animal tests are not always reliable for accurately identifying human teratogens, as evidenced by the infamous thalidomide case. Therefore, there is a...
UC2288-Mediated Increased Osteogenic Expression in Mesenchymal Stem Cells [0.03%]
UC2288介导的间充质干细胞成骨表达增加
Sina Jafari,Julie Sandria,Priyatha Premnath
Sina Jafari
p21 is a cell cycle regulator that has been implicated in regeneration of tissues and in development of certain tumors. p21 inhibition also enhances bone regeneration after injury in p21-/- mice. To translate these findings to the clinic, w...
Come Fly with Me: Drosophila Intestinal Stem Cells as a Model for Epithelial Homeostasis and Disease [0.03%]
与果蝇肠道干细胞一起探索上皮稳态和疾病机制
Fanila Shahzad,David P Doupé
Fanila Shahzad
Epithelial tissues rely on tightly regulated stem cell populations to sustain self-renewal and repair, with fundamental signaling pathways and molecular mechanisms playing conserved roles across species. While mammalian models, particularly...
Intravenous Allogeneic Mesenchymal Stem Cell Therapy for Canine Immune-Mediated Hemolytic Anemia: A Retrospective Clinical Evaluation [0.03%]
犬免疫介导性溶血性贫血的异体间充质干细胞静脉输注治疗：一项回顾性临床研究评估
Steven D Garner,Emily D Laughrun
Steven D Garner
This study evaluates the clinical efficacy and safety of intravenous allogeneic mesenchymal stem cell (MSC) therapy as an adjunct to standard immunosuppressive treatment in dogs diagnosed with primary immune-mediated hemolytic anemia (IMHA)...
Amelogenin Promotes Periodontal Bone Regeneration by Inducing Bone Marrow Mesenchymal Stem Cell Homing [0.03%]
釉丛蛋白通过诱导骨髓间充质干细胞归巢促进牙周骨再生
Haijuan Zhang,Yuxuan Yang,Yandong Han et al.
Haijuan Zhang et al.
Amelogenin has been widely used in clinical practice for periodontal bone regeneration. However, the precise mechanism underlying its osteogenic effects remains incompletely understood. In this study, we hypothesized that amelogenin enhance...
The Effect of the Inflammatory Microenvironment on Odontogenic Differentiation of Dental Pulp Stem Cells [0.03%]
炎症微环境对牙髓干细胞成odontogenic分化的影响
Shangzhou Jiang,Youkai Lin,Dingming Huang et al.
Shangzhou Jiang et al.
The dental pulp not only serves as the tooth's nutritional core but also creates a finely tuned microenvironment that is enriched with blood vessels, nerves, extracellular matrix components, and signaling molecules, all of which guide the f...
Stem Cells from Human Exfoliated Deciduous Teeth Improve Motor Function after Sciatic Nerve Injury Through Suppression of Inflammation [0.03%]
人乳牙干细胞通过抑制炎症来改善坐骨神经损伤后的运动功能
Takahiro Oyama,Koji Osuka,Yusuke Nishimura et al.
Takahiro Oyama et al.
Stem cell therapy employing stem cells from human exfoliated deciduous teeth (SHED) has demonstrated efficacy in treating peripheral nerve injury; however, the precise underlying mechanisms remain largely undefined. In this study, we invest...
Advances in Sickle Cell Disease Treatment: A Comparative Review of Hematopoietic Stem Cell Transplantation and Gene Therapy (Casgevy and Lyfgenia) [0.03%]
镰状细胞病治疗进展：造血干细胞移植与基因治疗（Oxbryta和L-glutamine）的比较分析
Omer Tarig Fathi Abdelazim,Abu-Baker Khalid Sharafeldin,Mohammed Kawari et al.
Omer Tarig Fathi Abdelazim et al.
Sickle cell disease (SCD), affecting approximately 2.1% of Bahrain's population, is a prevalent inherited disorder that necessitates effective treatments and long-term management. This review highlights two innovative gene therapies (Casgev...
Impact of Mitochondrial A3243G Mutation on Skeletal Muscle Energy Metabolism: Evidence from Human Induced Pluripotent Stem Cell-Derived Skeletal Muscle Cells [0.03%]
线粒体A3243G突变对骨骼肌能量代谢的影响：来自诱导多能干细胞来源的骨骼肌细胞的证据
Ritsuko Oikawa,Kenichi Yokota,Junji Fujikura et al.
Ritsuko Oikawa et al.
The study of skeletal muscle disorders in patients with mitochondrial diseases is crucial for gaining insights into disease physiology; however, their molecular mechanisms have not been fully elucidated. We previously established human-indu...
Extracellular Vesicles from Mesenchymal Stromal Cells Modulate Inflammatory Responses on Feline Mixed Glia [0.03%]
骨髓间质干细胞源性细胞外囊泡调节猫混合胶质细胞的炎症反应
Nikolia Darzenta,Emily Davis,Anna Cochran et al.
Nikolia Darzenta et al.
The extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSC-EVs) exhibit immunoregulatory functions dependent on their parent cells. MSC-EVs are promising candidates for treating neuroinflammation in neurological diseases du...