Carlos Eduardo da Silva Gonçalves,Andressa Antunes Santos,Tálita Sartori et al.
Carlos Eduardo da Silva Gonçalves et al.
Vitamins are well known for their essential role in maintaining organismal homeostasis by directly influencing the function of a variety of cells. Among the tissues crucial for sustaining life is the bone marrow, where the highly organized ...
The Specification and Functional Maturation of Sub-Cerebral Projection Neurons Derived from Human Induced Pluripotent Stem Cells [0.03%]
人诱导多能干细胞衍生的皮质下投射神经元的功能成熟度及分化标准
Zachary Jordan,Anukriti Singh,Seth Kattapong-Graber et al.
Zachary Jordan et al.
Human induced pluripotent stem cells (hiPSC) are an invaluable resource for investigating the molecular mechanisms regulating cell fate specification during brain development. However, most directed differentiation methods exhibit significa...
Basement Membrane of Hertwig's Epithelial Root Sheath Is Involved in Dental Follicle Cell Differentiation into Cementoblasts [0.03%]
赫特威根上皮鞘基底膜参与牙囊细胞分化为牙骨质细胞
Yoshiko Shindo,Shojiro Ikezaki,Tomoaki Iwayama et al.
Yoshiko Shindo et al.
The cementum is a mineralized tissue that covers the tooth root and is necessary for anchoring periodontal ligament fibers to the teeth. During root development, dental follicle (DF) cells differentiate into cementoblasts, periodontal ligam...
ADAMTS2 Mediates Osteogenic Differentiation of Dental Follicle Stem Cells Under Compressive Stress and Inflammation [0.03%]
压缩和炎症刺激下牙囊干细胞成骨分化的调控机制研究
Zhe Zhou,Dongyang Li,Jie Zhang et al.
Zhe Zhou et al.
This study investigates the effects of inflammation and orthodontic forces on the osteogenic differentiation of human dental follicle stem cells (hDFSCs) and their role in periodontal regeneration during orthodontic tooth movement (OTM) in ...
Administration of Glucose-Encapsulated Liposomes with Sialyl Lewis X on the Surface Improves Stroke Outcomes in Mice [0.03%]
表面带有唾液酸Lewis X的葡萄糖被封装脂质体的给药可改善小鼠的中风预后
Yuka Okinaka,Koki Kamiya,Hiromitsu Ohzeki et al.
Yuka Okinaka et al.
Hematopoietic stem cell (HSC) transplantation improves stroke outcomes. The mechanism of HSC transplantation involves delivering metabolites, such as glucose, to injured cerebral endothelial cells via gap junctions. To mimic HSC function, w...
POSTN+ Cancer-Associated Fibroblasts Promote Gastric Cancer Invasion by Activating AKT Signaling [0.03%]
POSTN阳性癌症相关成纤维细胞通过激活AKT信号促进胃癌侵袭转移
Xiuxiu Xu,Tingting You,Zhao Sun et al.
Xiuxiu Xu et al.
Metastasis is the primary cause of death in advanced/recurrent cancer patients. Cancer metastatic capability depends not only on cancer cells but also on the cancer microenvironment, particularly cancer-associated fibroblasts (CAFs), a high...
Delta 9-Tetrahydrocannabinol Signaling Through Cannabinoid Receptor 1 Alters Trophoblast Differentiation [0.03%]
大麻素受体1介导的Δ9-四氢大麻酚信号通过改变滋养细胞分化作用于早期妊娠组织微环境
Jessica L Koven,Bryony V Natale,Daniel B Hardy et al.
Jessica L Koven et al.
Cannabis use during pregnancy is increasing. In rodent models of delta-9 tetrahydrocannabinol (Δ9-THC) exposure during pregnancy, placental pathology, including compromised labyrinth development, is reported. Cannabinoid receptor 1 (CB1/Cn...
Strong Transcriptional Signature of Mesenchymal Stromal Cells from Perinatal Tissues Compared with Adult Bone Marrow Sources Independent of Donors or Culture Conditions [0.03%]
来自围产期组织的间充质基质细胞与成人骨髓来源的间充质基质细胞具有较强的转录特征独立于供体或培养条件
Christophe Desterke,Christophe Martinaud,Marie-Caroline Le Bousse-Kerdilès et al.
Christophe Desterke et al.
Mesenchymal stromal cells (MSCs) are currently used in clinical practice as a therapeutic agent for immunomodulation and tissue repair. They are found in all supporting tissues, including perinatal tissues such as umbilical cord and amnioti...
Human Urine-Derived SIX2-Positive Renal Progenitor Cells Partially Improve Kidney Fibrosis by Paracrine Signaling [0.03%]
人尿液衍生的SIX2阳性肾祖细胞通过旁分泌信号在一定程度上改善肾脏纤维化
Claus Kordes,Lucas-Sebastian Spitzhorn,Martina Bohndorf et al.
Claus Kordes et al.
Cells with renal progenitor cells characteristics are shed in urine. This study aimed to investigate whether these SIX2-positive urine-derived renal progenitor cells (UdRPC) have therapeutic potential in treating or managing acute to chroni...
Decidual and Endometrial Multipotent Mesenchymal Stromal Cells: Emerging Therapeutic and Clinical Approaches for Intrauterine Adhesion Repair [0.03%]
蜕膜和子宫内膜多能间充质干细胞：宫腔粘连修复的新疗法及临床应用展望
Xiaochuan Yu,Lijuan Shi,Yating Zhang et al.
Xiaochuan Yu et al.
Intrauterine adhesion (IUA), a prevalent cause of female infertility and recurrent pregnancy loss, is characterized by endometrial trauma and progressive fibrosis. Current treatment modalities, including hysteroscopic adhesiolysis and hormo...