Regulation of Cochlear Nucleus Synaptogenesis by Progranulin in a Stem Cell-Based Coculture Model [0.03%]
基底前庭干细胞共培养系统中progranulin对耳蜗核突触发生的作用机制研究
Anika Tabassum,Pagadala Praveena Reddy,Oluwafemi Agboola et al.
Anika Tabassum et al.
The cochlear nucleus (CN) is the first central relay of auditory information, receiving input from spiral ganglion neurons (SGNs) through specialized synapses whose molecular regulation remains incompletely defined. Here, we examined the ro...
Effects of Sestrin2 on Angiogenesis of Human Umbilical Vein Endothelial Cells in Hypoxia Environment [0.03%]
Sestrin2对低氧环境下人脐静脉内皮细胞血管生成的影响
Rui Chen,Lina Ren,Sen Xu et al.
Rui Chen et al.
Prevascularized cell sheets are widely used in tissue engineering; however, enhancing their angiogenic potential within hypoxic microenvironments remains a significant challenge. In this study, we employed genetic manipulation to upregulate...
Efficacy and Safety of Mesenchymal Stem Cell Therapy for Alzheimer's Disease: A Systematic Review and Meta-Analysis [0.03%]
间充质干细胞治疗阿尔茨海默病的疗效和安全性系统评价和 meta 分析
Yonghao Wen,Shuhao Zhan,Yunlong Duan et al.
Yonghao Wen et al.
Alzheimer's disease (AD) is the leading cause of dementia, and effective disease-modifying therapies remain limited. Mesenchymal stem cells (MSCs) have shown therapeutic potential because of their neuroprotective and immunomodulatory proper...
Long-Term Survival, Illness Severity, and Time-to-Treatment Analysis in Dogs with Immune-Mediated Hemolytic Anemia Following Intravenous Allogeneic Mesenchymal Stem Cell Therapy: A Multicohort Follow-Up Study [0.03%]
静脉输注同种异体间充质干细胞治疗免疫介导性溶血性贫血犬的长期存活率、疾病严重程度及治疗时机分析：多队列随访研究
Steven D Garner,Emily D Laughrun,Melinda Wharton
Steven D Garner
Steroid-refractory immune-mediated hemolytic anemia (IMHA) in dogs carries high early mortality, and the 15%-30% of cases that fail corticosteroid-based therapy represent a population with few effective options and a narrowing treatment win...
Raed Said,Helya Mortazavi,Ibrahim Hoja et al.
Raed Said et al.
Most cellular and physiological activities are temporally organized, with many following robust circadian oscillations over the 24-h day. Mineralized dental tissues formation during odontogenesis provide an especially tractable model to stu...
ATG5 Engineers Stem Cell Plasticity to Regulate Functional Fitness During Development and Disease [0.03%]
ATG5调控发育和疾病期间干细胞的可塑性以调节其功能适应度
Fahika Nazeerulla,Ishani Banerjee,Manash Kumar Paul et al.
Fahika Nazeerulla et al.
Autophagy, an evolutionarily conserved and tightly controlled process in eukaryotic cells, allows them to respond to stress by selectively eliminating dysfunctional or unwanted materials to promote metabolic flexibility and maintain homeost...
Inflammatory Preconditioning Reprograms Mesenchymal Stromal Cell-Derived Extracellular Vesicles into Distinct Functional States for Immunomodulation and Wound Healing [0.03%]
炎症预处理可将间充质基质细胞来源的外泌体重编程为具有不同免疫调节和促进伤口愈合功能的状态
Ramiro A Villarreal-Leal,Oscar S Velazquez,Beck Burgelin et al.
Ramiro A Villarreal-Leal et al.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are emerging as potent cell-free mediators of tissue repair, whose composition and function can be tuned by the cellular microenvironment. Although inflammatory cues modulate...
Cancer Stem Cells as Dynamic Attractor States: Systems Biology of Tumor Plasticity and Therapy Resistance [0.03%]
癌症干细胞作为动态吸引子状态：肿瘤可塑性和治疗抵抗的系统生物学
Mahendra Aryal
Mahendra Aryal
The cancer stem cell (CSC) paradigm has evolved from a rigid hierarchical model to a systems-level perspective in which stemness is a reversible and context-dependent phenotype. Evidence from lineage tracing and single-cell/spatial multiomi...
Evaluation of Puromycin-Induced Podocyte Injury and Protective Effects of Voclosporin Using Induced Pluripotent Stem Cells from a Patient with Nephrotic Syndrome Harboring an INF2 Variant [0.03%]
评估携带INF2变异体的肾病综合征患者诱导多能干细胞中puromycin引起的podocyte损伤及voclosporin的保护作用
Akihito Tanaka,Kazuhiro Furuhashi,Saki Sakamoto et al.
Akihito Tanaka et al.
Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and end-stage kidney disease (ESKD). Many cases are attributable to pathogenic variants in podocyte-related genes, such as inverted formin 2 (INF2). However, n...