Robert A Gaultney,Anja Herbst,Jeremy Yeoh et al.
Robert A Gaultney et al.
Alarmins, a group of molecules that function to signal cell stress or death, are a key regulator of the immune response to localized insults. A tissue type often exposed to challenging conditions is the mucosa. As mucosal tissues commonly s...
Eden M Jacob,Seth D Fortmann,Nobuhiko Shiraki et al.
Eden M Jacob et al.
Macrophages are no longer viewed as transient immune passersby but as integral tissue components that regulate physiological homeostasis. Many resident macrophage populations are seeded prenatally and maintained locally, whereas others are ...
Beyond suppression: Treg specialization in infection and tissue repair [0.03%]
超越抑制：感染和组织修复过程中Treg的特化作用
Morgane Hilaire,Nicole Joller
Morgane Hilaire
Regulatory T cells (Tregs) play a critical role in maintaining immune homeostasis and tolerance. While their suppressive function is beneficial in autoimmunity and detrimental in cancer, Tregs also exert essential roles during infections wh...
Marina Mayer,Eliana Franco Taveras,Elvira Mass
Marina Mayer
Macrophages are essential immune cells that arise early during embryogenesis and persist as tissue-resident cells into adulthood. This chapter explores macrophage development, focusing on their roles in the nervous system. We describe their...
Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues [0.03%]
超越中枢神经系统的神经免疫学：外周组织中的神经-巨噬细胞相互作用
Erin Watson,Elaine Emmerson
Erin Watson
Macrophages are now recognised to be highly heterogeneous, with diverse ontogenies, anatomical locations and characteristics, all of which inform their function. Nerve-associated macrophage subpopulations have been found to exist across tis...
Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination [0.03%]
γδ T细胞调节体液免疫：疫苗接种的潜在佐剂策略
Kirsty Emery,Matthias Eberl
Kirsty Emery
Vaccination is arguably the most effective intervention in reducing the impact of infectious diseases. However, many vaccines provide only partial or transient protection, prompting the need for more effective solutions based on our growing...
Rebecca A Drummond
Rebecca A Drummond
Fungal infections are increasingly recognised as a major threat to global human health, with several million preventable deaths each year now attributable to fungal diseases. Climate change, global pandemics and increased use of antibiotics...
Rakesh Pahwa,Gulshan Sharma,Rohil Panwar et al.
Rakesh Pahwa et al.
The emergence of mRNA-based cancer immunotherapy has transformed the avenue of cancer treatment, offering an innovative strategy that leverages the body's immune system to identify and eradicate tumor cells selectively. Effective delivery o...
Gyati Shilakari Asthana,Saptarshee Bhattacharjee,Jitendra Kumar et al.
Gyati Shilakari Asthana et al.
Lipid nanoparticles (LNPs) to deliver messenger RNA (mRNA) have emerged as a transformative strategy in cancer immunotherapy. This chapter explores the pivotal role of LNPs in enabling the efficient and targeted delivery of mRNA for cancer ...
Recent progress, challenges (stability and in vivo distribution), and opportunities of DNA & mRNA vaccine in cancer immunotherapy [0.03%]
DNA和mRNA疫苗在肿瘤免疫治疗中的最新进展、挑战（稳定性及体内分布）与机遇
Monika Kaushik,Prathap Madeswaraguptha,Murugesan Vanangamudi et al.
Monika Kaushik et al.
Cancer immunotherapy recently has emerged as a revolutionary method in oncology. It takes the help of the body's immune system in fighting against tumor cells. Amongst the various approaches, DNA and mRNA vaccines are novel modalities with ...