Critical Care and Contagion: Evolving Frontiers of Infectious Diseases in the Modern Intensive Care Unit [0.03%]
重症监护与传染：现代重症监护室传染病的前沿问题及发展趋势
Christina Yek,Sameer S Kadri
Christina Yek
Ryan C Maves,Sabrina Z Siddiqui
Ryan C Maves
Sepsis is a leading cause of death worldwide, disproportionately affecting low-resource settings. Limited diagnostics, antimicrobial resistance, and scarce critical care capacity compound the burden. Areas for improved care include physiolo...
The Respiratory Triple Pandemic in the Intensive Care Unit: Epidemiology, Clinical Features and Management of COVID-19, Influenza and Respiratory Syncytial Virus [0.03%]
重症监护病房的呼吸系统三重流行病：COVID-19、流感和呼吸道合胞病毒的流行病学、临床特征及管理
Daniel Anthony Sweeney,Xavier Wittebole,Andre Celestino Kalil
Daniel Anthony Sweeney
The anticipated "tripledemic" during the 2023-2024 season-in which simultaneous epidemics of SARS‑CoV‑2, influenza, and respiratory syncytial virus were projected-ultimately fell short of early forecasts. Nevertheless, each virus remains ...
Armani M Hawes,Sara E Cosgrove
Armani M Hawes
Intensive care units (ICUs) care for the most severely ill patients and consequently account for the largest volume of antibiotic use in the hospital. Critically ill patients must receive optimal, timely empiric antibiotic therapy. However,...
Brooke K Decker,Matthew O&#x;Donnell
Brooke K Decker
Health care-associated infections are common and burdensome in intensive care units, contributing to increased costs, morbidity, and mortality. The coronavirus disease 2019 (COVID-19) pandemic led to an increase in the incidence of intensiv...
Antibiotic Considerations in the Critically Ill: Empiric Choices and Dosing [0.03%]
危重患者的抗生素选择与剂量考虑：经验性用药与给药方案
Eric M Gillett,Kevin M Dube,Chanu Rhee
Eric M Gillett
Treating infections in critically ill patients is uniquely challenging because of diverse disease states, high rates of antimicrobial resistance, pharmacokinetic changes, and a high risk of mortality that leaves little margin for error. Opt...
Recognizing and Managing Hemophagocytic Lymphohistiocytosis in Adults in the Intensive Care Unit [0.03%]
重症监护病房成人噬血细胞综合征的认识与处理
Bita Shakoory,Irini Sereti,Joseph M Rocco
Bita Shakoory
Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory syndrome increasingly recognized across age groups. This syndrome is driven by pathologic interferon-γ production, which leads to a self-sustaining positive feedbac...
Maureen Thivierge-Southidara,Alexander Lawandi
Maureen Thivierge-Southidara
Lower respiratory tract infections are the most common cause of death globally, representing the leading source of infection among patients admitted to the intensive care unit. Rapid and accurate pathogen identification allows a targeted th...
Mary Cunnion,Stephanie Bonne
Mary Cunnion
Source control is a cornerstone of managing infections and sepsis in the intensive care unit, requiring rapid recognition of infection, targeted diagnostic evaluation, and timely procedural or surgical intervention. This article presents a ...
The Global Intensive Care Unit: Human Immunodeficiency Virus, Tuberculosis, and Malaria [0.03%]
全球重症监护室：人类免疫缺陷病毒、结核病和疟疾
Felix Riunga,Gladys Mbatha Wambua,Burton W Lee
Felix Riunga
More than 80% of the world's population lives in low-income and middle-income countries, yet access to critical care remains limited in these regions. Infectious diseases, especially human immunodeficiency virus, tuberculosis, and malaria, ...